Recent advances in the understanding of the genetic, neurochemical, behavioral and cultural underpinnings of addiction have led to rapid advances in the understanding of addiction as a disease. In fact, advances in basic science and the development of new pharmacological and behavioral therapies associated with them are appearing faster than can be assimilated not only by clinical researchers but practitioners and policy makers as well. Translation of science-based addictions knowledge into improved prevention, assessment and treatment, and communication of these changes to researchers and practitioners are significant challenges to the field. The general aim of this book is to summarize current and potential linkages between advances in addiction science and innovations in clinical practice. Whilst this book is primarily focused on translation, it also encompasses some scientific advances that are relevant to dissemination, and the book is itself a tool for disseminating innovative thinking. The goal is to generate interest in application opportunities from both recent research and theoretical advances.

Key Features

*Provides a much needed resource for translating current research into clinical practice *Focuses upon alcohol, tobacco, and substance abuse addictions *Addresses method of research and best dissemination techniques


Researchers in addiction, academic clinical researchers in addiction, practitioners and policy makers who are committed to a scientist-practitioner model and are interested in advances in their field.

Table of Contents

TRANSLATION OF ADDICTIONS SCIENCE INTO PRACTICE: UPDATE AND FUTURE DIRECTIONS Peter M. Miller and David J. Kavanagh List of Contributors Preface SECTION I: GENETICS AND NEUROSCIENCE Chapter 1 The Interplay between Genotype and Gene Expression in Human Brain: What Can It Teach Us about Alcohol Dependence? (Dodd) Chapter 2 Common Genetic Influences on Antisociality and Addictions: Implications for Clinical Science and Practice (King) Chapter 3 Opioids, Pain and Addiction: Cause and Consequence (White and Hay) Chapter 4 Imbalance between Neuroexcitatory and Neuroinhibitory Amino Acids Causes Craving for Ethanol: From Animal to Human Studies (DeWitte) Chapter 5 Cannabis and the Brain: Implications of Recent Research (Sundram and Castle) SECTION II. PHARMACOTHERAPY Chapter 6 The Plasticity of Alcohol Addiction Suggests Novel Approaches to Pharmacological Intervention (Mulholland And Chandler) Chapter 7 Pharmacotherapies for the Treatment of Alcohol Dependence: Current and on the Horizon (Wright, Baros, Anton) Chapter 8 Agonist Treatment for Stimulant Abuse and Dependence (Herin and Grabowski) Chapter 9 Topiramate-Induced Neuromodulation of Cortico-Mesolimbic Dopamine: Implications for the Treatment of Nicotine and Alcohol Dependence (Johnson) SECTION III. PSYCHOLOGY AND SOCIOLOGY Chapter 10 Advances in the Scientific Study of Craving for Alcohol and Tobacco (MacKillop and Monti) <


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About the editors

Peter Miller

Peter M. Miller, Ph.D., is a clinical psychologist and Professor of Psychiatry and Behavioral Sciences in the Center for Drug and Alcohol Programs at the Medical University of South Carolina. He is Editor-in-Chief of the journal Addictive Behaviors and an experienced researcher and clinician in the field of alcohol use disorders.

Affiliations and Expertise

Medical University of South Carolina, Charleston, USA

David Kavanagh

Affiliations and Expertise

Royal Brisbane Hospital, School of Medicine, University of Queensland, AUSTRALIA