Translating Epigenetics to the Clinic - 1st Edition - ISBN: 9780128008027, 9780128006122

Translating Epigenetics to the Clinic

1st Edition

Editors: Jeffrey Laurence
eBook ISBN: 9780128006122
Hardcover ISBN: 9780128008027
Imprint: Academic Press
Published Date: 3rd January 2017
Page Count: 324
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Description

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing.

Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.

Key Features

  • Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinic
  • Features extensive pedagogical updates aiming to improve the education of translational researchers in this field
  • Offers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

Readership

Translational researchers and clinicians

Table of Contents

  • List of Contributors
  • Chapter 1. Epigenetic Regulation of Open Chromatin in Pluripotent Stem Cells
    • Abstract
    • Abbreviations
    • Introduction
    • Chromatin decondensation at the microscopic level
    • Permissive transcription
    • Chromatin remodeling complexes
    • Histone modifications
    • DNA methylation
    • Noncoding RNAs
    • Dynamic movement of chromatin proteins
    • Nucleosome accessibility and positioning
    • Long-range chromosomal interactions
    • Future perspectives
    • Acknowledgment
    • References
  • Chapter 2. RNA Epigenetics (Epitranscriptomics)
    • Abstract
    • Abbreviations
    • Introduction
    • Techniques used to study m6A in mRNA/lncRNA
    • m6A writers
    • m6A erasers
    • m6A readers
    • m6A switches
    • m6A modification in human health and disease
    • RNA epigenetics beyond m6A in mRNA/lncRNA
    • Concluding remarks
    • Acknowledgments
    • References
  • Chapter 3. The Nucleosome Remodeling and Deacetylase Complex in Development and Disease
    • Abstract
    • Introduction
    • NuRD biochemistry
    • NuRD and ES cells
    • NuRD and embryonic development
    • NuRD and cancer
    • DNA damage response and genome integrity
    • Conclusions
    • References
  • Chapter 4. Epigenetics and Muscle Dysfunction in Chronic Obstructive Pulmonary Disease
    • Abstract
    • Introduction
    • Skeletal muscle dysfunction in COPD
    • Multifactorial etiology of muscle dysfunction in COPD
    • Epigenetic events in cells and tissues
    • Development of skeletal muscle fibers
    • Epigenetic regulation in normal skeletal muscles
    • Epigenetic regulation in skeletal muscles of COPD patients
    • Conclusions and future perspectives
    • Acknowledgments
    • References
  • Chapter 5. Clinical Epigenetics of Lung Cancer
    • Abstract
    • Lung cancer
    • Epigenetic landscape of lung cancer
    • Common somatic mutations in epigenetic regulators
    • Epigenetic biomarkers for lung cancer
    • Epigenetic therapy
    • Summary
    • References
  • Chapter 6. Epigenetics in Cardiovascular Disease
    • Abstract
    • Abbreviations
    • Introduction
    • Epigenetic mechanisms in CVD
    • Translating epigenetic findings to improved outcomes
    • Conclusions and future directions
    • References
  • Chapter 7. Epigenetics and Arterial Hypertension: Evidences and Perspectives
    • Abstract
    • Abbreviations
    • Introduction
    • Epigenetic regulation through DNA methylation, histone modification, and microRNA
    • Conclusions
    • References
  • Chapter 8. Epigenetics in Chronic Pain
    • Abstract
    • Abbreviations
    • Introduction
    • DNA methylation and demethylation
    • Chromatin remodeling
    • Noncoding RNA
    • Summary and future directions
    • Acknowledgments
    • References
  • Chapter 9. Epigenomics of Alzheimer’s Disease
    • Abstract
    • Abbreviations
    • Aging and dementia
    • Clinical and neuropathologic features of AD
    • Heritability of AD
    • Genetics of AD
    • Epigenetics of AD
    • Future directions
    • Acknowledgments
    • References
  • Chapter 10. Prospective Epigenetic Paradigms and Models for Cellular Senescence and Epithelial–Mesenchymal Transition in Organismal Development and Aging
    • Abstract
    • Introduction
    • EMT Versus MET in Development, Cancer, and Senescence
    • Importance of Epigenetic Transition and Conversion in “Rejuvenative Senescence”
    • Transcription Factors as Epigenetic Driving Forces Between EMT and MET in Cellular Senescence and Aging
    • Developmental Senescence and Biochronological Aging via the Pathophysiological EMT–MET Process in Epigenesis
    • New Paradigms of Basic Biological Models for The EMT–MET Process and Epigenetics
    • Concluding Remarks to Aim Future Therapeutic Interventions by Epigenetics on Aging
    • Acknowledgments
    • References
  • Index

Details

No. of pages:
324
Language:
English
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128006122
Hardcover ISBN:
9780128008027

About the Editor

Jeffrey Laurence

Dr Laurence is pursuing the pathophysiology of cardiovascular and skeletal abnormalities linked to HIV disease and its therapies at Weill Cornell. Dr Laurence is the editor-in-chief of Translational Medicine, which Elsevier co-publishes with the CSCTR.

Affiliations and Expertise

Weill Cornell Medical College, New York, NY, USA