Transition Metal Toxicity - 1st Edition - ISBN: 9780123649317, 9781483218403

Transition Metal Toxicity

1st Edition

Editors: G. W. Richter Kim Solez
eBook ISBN: 9781483218403
Imprint: Academic Press
Published Date: 28th November 1990
Page Count: 206
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Description

International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of metal ions in biological systems; oxidative stress during the metabolic interactions of metal ions; and the actions of oxygen-derived free radicals in the pathogenesis of metal ion toxicity. The book also describes the roles played by chromium and other metals in carcinogenesis; the morphologic pathology of metal toxicosis; and metal ion overload due to inborn metabolic defects, as well as to excessive environmental exposure. Research findings at the molecular, cellular, and organ levels are reviewed. Physiologists, biochemists, pathologists, and biophysicists will find the book invaluable.

Table of Contents


Contributors

Preface

Iron Toxicosis

I. Introduction: History and Prevalence of Iron Toxicosis

II. Chemistry of Iron Toxicity

III. Pathophysiology of Iron Overload

IV. Treatment of Iron Overload

References

Host Defenses against Copper Toxicity

I. Essentiality of Copper in Normal Metabolism

II. Balance between Essential Copper Levels and Toxicosis

III. Regulation of Copper Balance: Control of Homeostasis in Animals

IV. Copper Homeostasis in Nonanimal Cells

V. Conclusions

References

Chromium Toxicity and Carcinogenesis

I. Introduction

II. Uptake-Reduction Model of Chromium(VI) in the Cell

III. Chromium(VI)-Induced DNA Damage

IV. Conclusion

References

The Chemistry of Dioxygen Species (O2, O2-, HOO·, and HOOH) and Their Activation by Transition Metals

I. Introduction

II. Redox Chemistry of O2, O2-, and HOOH

III. Reactivity of O2- and HOO·

IV. Iron-Induced Activation of HOOH

V. Iron-Induced Activation of Dioxygen

References

Transition Metal Ions and Oxygen Radicals

I. Introduction

II. The Chemistry of Oxygen Species

III. The Biochemistry and Biology of Oxygen Species

IV. Mechanism of the Toxicity of Oxygen Radicals

V. The Dual Effect of Transition Metal Ions

VI. Defenses against Oxygen Species Derived Damage

References

The Cytopathology of Metal Overload

I. Introduction

II. Iron

III. Copper

References

Index

Details

No. of pages:
206
Language:
English
Copyright:
© Academic Press 1990
Published:
Imprint:
Academic Press
eBook ISBN:
9781483218403

About the Editor

G. W. Richter

Kim Solez

Affiliations and Expertise

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton

Ratings and Reviews