Transition Metal Toxicity

Transition Metal Toxicity

1st Edition - November 28, 1990

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  • Editors: G. W. Richter, Kim Solez
  • eBook ISBN: 9781483218403

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International Review of Experimental Pathology, Volume 31: Transition Metal Toxicity merges discussions of normal and deranged metabolism of transition metals; redox cycling of metal ions in biological systems; oxidative stress during the metabolic interactions of metal ions; and the actions of oxygen-derived free radicals in the pathogenesis of metal ion toxicity. The book also describes the roles played by chromium and other metals in carcinogenesis; the morphologic pathology of metal toxicosis; and metal ion overload due to inborn metabolic defects, as well as to excessive environmental exposure. Research findings at the molecular, cellular, and organ levels are reviewed. Physiologists, biochemists, pathologists, and biophysicists will find the book invaluable.

Table of Contents

  • Contributors


    Iron Toxicosis

    I. Introduction: History and Prevalence of Iron Toxicosis

    II. Chemistry of Iron Toxicity

    III. Pathophysiology of Iron Overload

    IV. Treatment of Iron Overload


    Host Defenses against Copper Toxicity

    I. Essentiality of Copper in Normal Metabolism

    II. Balance between Essential Copper Levels and Toxicosis

    III. Regulation of Copper Balance: Control of Homeostasis in Animals

    IV. Copper Homeostasis in Nonanimal Cells

    V. Conclusions


    Chromium Toxicity and Carcinogenesis

    I. Introduction

    II. Uptake-Reduction Model of Chromium(VI) in the Cell

    III. Chromium(VI)-Induced DNA Damage

    IV. Conclusion


    The Chemistry of Dioxygen Species (O2, O2-, HOO·, and HOOH) and Their Activation by Transition Metals

    I. Introduction

    II. Redox Chemistry of O2, O2-, and HOOH

    III. Reactivity of O2- and HOO·

    IV. Iron-Induced Activation of HOOH

    V. Iron-Induced Activation of Dioxygen


    Transition Metal Ions and Oxygen Radicals

    I. Introduction

    II. The Chemistry of Oxygen Species

    III. The Biochemistry and Biology of Oxygen Species

    IV. Mechanism of the Toxicity of Oxygen Radicals

    V. The Dual Effect of Transition Metal Ions

    VI. Defenses against Oxygen Species Derived Damage


    The Cytopathology of Metal Overload

    I. Introduction

    II. Iron

    III. Copper



Product details

  • No. of pages: 206
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: November 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9781483218403

About the Editors

G. W. Richter

Kim Solez

Affiliations and Expertise

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton

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