COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Transgenesis and Targeted Mutagenesis in Immunology - 1st Edition - ISBN: 9780121057602, 9781483296494

Transgenesis and Targeted Mutagenesis in Immunology

1st Edition

Serial Editors: Horst Bluethmann Pamela Ohashi
eBook ISBN: 9781483296494
Hardcover ISBN: 9780121057602
Paperback ISBN: 9781493304547
Imprint: Academic Press
Published Date: 16th June 1994
Page Count: 316
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for fresh observations and interpretations when designing future experiments.

Key Features

Special Features Include:
Contributions of two Nobel Prize winners
Addresses the use of mouse models in studying the immune system
Targets gene distribution in embryonic stem cells and their introduction into blastocyte mice models
Analyzes the in vivo functional loss of embryonic cells
A practical, useful guidebook for individual researchers, laboratories, and libraries


Researchers in immunology, cell biology, molecular biology, molecular genetics, pharmacology, and toxicology.

Table of Contents

F. Wartin, C. Fernex, M. Capone, B. Horvat, D. Caillol, and P. Ferrier, Transgenic Mouse Models to Study VDJ Recombination. P. Mombearts and S. Tonegawa, Lymphocyte Development and Function in T Cell Receptor and RAG-1 Mutant Mice. J. Chen and F.W. Alt, RAG-2-Deficient Blastocyst Complementation. C.B. Davis and E.A. Robey, Role of CD4 and CD8 in Determining Cell Fate in the Thymus. V.A. Wallace, J. Penninger, and T.W. Mak, T Cell Development in CD4, CD8, and p561ck Gene–Targeted Mice. J.D. Mountz, T. Zhou, and H. Bluethmann, T Cell Tolerance in T Cell Receptor Transgenic 1pr/1pr Mice . P.S. Ohashi, H. Hengartner, M. Battegay, R.M. Zinkernagel, and H. Pircher, ThymocyteSelection and Peripheral Tolerance Using the Lymphocytic Choriomeningitis Virus as a Model Antigen. B. Arnold, G. Schinrich, I. Ferber, J. Alferink, and G. J. Hemmerling, Peripheral T Cell Tolerance: Distinct Levels and Multistep Mechanisms. B. Scott and D. Lo, Peripheral Tolerance and the CD4<+>+ T Cells. S. Antonia, E.A. Elliot, S. Guerder, D.E. Picarella, N.H. Ruddle, and R.A. Flavell, Studies of Tolerance, Inflammation, and Autoimmunity in Transgenic Mice. M.-S. Lee and N. Sarvetnick, Immunological Studies Utilizing Cytokine Transgenic Mice. R. Quartey-Papafino, L. O'Reilly, A.G. Baxter, P. Ozegbe, P.R. Hutchings, N.M. Parish, D.G. Healey, and A. Cooke, Effect of MHC Class II Encoding Transgenes on Autoimmunity in Nonobese Diabetic Mice. A. Schimpl, T. Hunig, A. Elbe, I. Berberich, S. Kremer, H. Merz, A.C. Feller, B. Sadlack, H. Schorle, and I. Horak, Development and Function of the Immune System in Mice with Targeted Disruption of the Interleukin-2 Gene. G.G. Brusselle, G. Le Gros, G. Kihler, N. Schultze, P. Koebel, J.C. Kips, R.A. Pauwels, and H. Bluethmann, Immune Responses in Interleukin 4-Deficient Mice. S.B. Hartley and C.C. Goodnow, Manipulation of Transgene-Encoded Self-Antigens to Explore Mechanisms of B Cell Tolerance. H. Eibel, P. Fiedler, and G. Kihler, Transgenic Mouse Model for Peripheral B Cell Tolerance. D.H. Raulet, Immunobiology of MHC Class I-Deficient Mice. M.J. Grusby, J. S. Markowitz, T.M. Laufer, R. Lee, H. Auchincloss,Jr., and L.H. Glimcher, MHC Class II Mutant Mice.


No. of pages:
© Academic Press 1994
16th June 1994
Academic Press
eBook ISBN:
Hardcover ISBN:
Paperback ISBN:

About the Serial Editors

Horst Bluethmann

Affiliations and Expertise

F. Hoffmann-LaRoche Ltd.

Pamela Ohashi

Affiliations and Expertise

Ontario Cancer Institute


@qu:The present volume represents a concise and complete guide to transgenesis and targeted mutagenesis in laboratory mice. Among the contributors are two Nobel Prize Winners. It can be highly recommended for specialists and scientists as well.
@qu:This book provides the reader instant access to many of the insights provided by the use of transgenic animals in the study of the structure and function of the immune system. The collection of chapters from prominent investigators demostrates the importance of this technique in contemporary research and the lucid and relevant presentations will be of great use to most researchers interested in the repercussions in their fields."

Ratings and Reviews