Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.
Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations.
This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.
- Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes
- Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies
- Covers history, future outlook, disease management and current controversies
Graduate students researching the fundamental basis of epigenetics to therapeutic interventions into epigenetic-based disorders
- Preface <li>Chapter 1. Transgenerational Epigenetics<ul><li>Introduction</li><li>Definition and History of Generational Epigenetic Inheritance</li><li>Germline Epigenetics</li><li>Epidemiology of Epigenetic Inheritance</li><li>Basic Mechanisms/Processes of Epigenetic Inheritance</li><li>Model Organisms</li><li>Evolution of Transgenerational Epigenetics</li><li>Parental Epigenetic Inheritance</li><li>Environmental Epigenetic Effects on the Offspring</li><li>Impact of Transgenerational Epigenetics on Disease</li><li>Clinical Significance of Transgenerational Epigenetics</li><li>Controversies and Debate of Generational Epigenetic Inheritance</li><li>Conclusion</li></ul></li> <li>Section I. Definitions and History of Generational Epigenetic Inheritance<ul><li>Chapter 2. Definition of Epigenetic Transgenerational Inheritance and Biological Impacts<ul><li>Introduction and Historical Context</li><li>Epigenetic Transgenerational Inheritance</li><li>Germline Epimutations</li><li>Transgenerational Inheritance of Disease and Phenotypic Variation</li><li>Transgenerational Disease Etiology</li><li>Impact and Future Studies</li><li>Glossary</li></ul></li><li>Chapter 3. Historical Perspective of Transgenerational Epigenetics<ul><li>Introduction</li><li>Shifting Paradigms of Heredity and Evolution</li><li>Early Evidence of Non-Mendelian Inheritance</li><li>The Origins of Epigenetics</li><li>Intersection of Phenomena and Mechanisms</li><li>Transgenerational Epigenetics in Ecology and Physiology</li><li>Conclusion</li></ul></li></ul></li> <li>Section II. Germline Epigenetics<ul><li>Chapter 4. Epigenetics and the Maternal Germline<ul><li>Introduction</li><li>Transgenerational Inheritance in the Maternal Germline</li><li>Discussion</li><li>Future Directions</li></ul></li><li>Chapter 5. Epigenetic Changes in the Paternal Germline<ul><li>Introduction</li><li>PGC Epigenetic Reprogramming</li><li>Epigenetics of Meiotic Prophase I</li><li>Histone-to-
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- © Academic Press 2014
- 12th May 2014
- Academic Press
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Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol’s research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women’s Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biot
Professor of Biology, University of Alabama at Birmingham, AL, USA
"This book is unique in its focus solely on this subject. This is an area destined to become extremely important in the practice of human and medical genetics. This book is without comparison. Score: 99 - 5 Stars"--Doodys.com, January 23, 2015
"...this seminal book on transgenerational epigenetics not only confronts these controversies, but also illuminates many other aspects of transgenerational epigenetics."--Anticancer Research, January 2015