- Print ISBN 9780124059443
- Electronic ISBN 9780124059221
Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.
Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations.
This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.
Graduate students researching the fundamental basis of epigenetics to therapeutic interventions into epigenetic-based disorders
"This book is unique in its focus solely on this subject. This is an area destined to become extremely important in the practice of human and medical genetics. This book is without comparison. Score: 99 - 5 Stars"--Doodys.com, January 23, 2015
"...this seminal book on transgenerational epigenetics not only confronts these controversies, but also illuminates many other aspects of transgenerational epigenetics."--Anticancer Research, January 2015