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Transfusion Medicine and Hemostasis

2nd Edition

Clinical and Laboratory Aspects

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Editors: Beth Shaz Christopher Hillyer

eBook ISBN: 9780123977885

Paperback ISBN: 9780123971647

Imprint: Elsevier Science

Published Date: 11th June 2013

Page Count: 1014

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Description

The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation.

New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals).

Key Features

Updated content covers new coagulation tests, cellular therapies, and quality control issues
Easy to use, with focused, well-defined chapters in a standardized format throughout
Offers quick "cross-reference" lists at the end of each chapter
Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

Readership

Residents and fellows in hematology, transfusion medicine, pathology, and anesthesiology; practicing physicians in hematology, transfusion medicine, pathology, and anesthesiology.

TABLE OF CONTENTS: I. Blood Banking and Transfusion Medicine A. Introduction 1. BLOOD BANKING AND TRANSFUSION MEDICINE – THE FIELD, THE DISCIPLINE AND THE INDUSTRY CHRISTOPHER D. HILLYER, MD 2. A BRIEF HISTORY OF BLOOD TRANSFUSION ALFRED J. GRINDON, MD 3. INTRODUCTION TO QUALITY SYSTEMS and QUALITY MANAGEMENT JIMMIE L. EVANS AND CHRISTOPHER D. HILLYER, MD B. Blood Banking 4. THE ROLE OF THE PHYSICIAN IN THE BLOOD CENTER CHRISTOPHER D. HILLYER, MD a. Donation process 5. BLOOD DONOR, DONATION PROCESS AND TECHNICAL ASPECTS OF BLOOD COLLECTION KRISTA L. HILLYER, MD 6. APHERESIS BLOOD COMPONENT COLLECTIONS KRISTA L. HILLYER, MD 7. RECIPIENT-SPECIFIC BLOOD DONATION KRISTA L. HILLYER, MD 8. ADVERSE DONOR REACTIONS KRISTA L. HILLYER, MD b. Component manufacturing 9. COMPONENT PREPARATION AND MANUFACTURING COURTNEY E. GREENE AND CHRISTOPHER D. HILLYER, MD c. Donor testing 10. SEROLOGIC TESTING OF DONOR PRODUCTS KRISTA L. HILLYER, MD 11. OVERVIEW OF INFECTIOUS DISEASE TESTING CHRISTOPHER D. HILLYER, MD 12. HIV SCREENING OF DONOR PRODUCTS KRISTA L. HILLYER, MD 13. HEPATITIS B SCREENING OF DONOR PRODUCT KRISTA L. HILLYER, MD 14. HEPATITIS C SCREENING OF DONOR PRODUCT KRISTA L. HILLYER, MD 15. WNV SCREENING OF DONOR PRODUCT KRISTA L. HILLYER, MD 16. SYPHILIS, HTLV, AND CHAGAS TESTING OF DONOR PRODUCT CHELSEA A. SHEPPARD, MD AND KRISTA L. HILLYER, MD 17. BACTERIAL DETECTION METHODS BETH H. SHAZ, MD C. Transfusion Medicine 18. THE ROLE OF THE TRANSFUSION SERVICE PHYSICIAN BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD a. Testing 19. PRETRANSFUSION TESTING BETH H. SHAZ, MD 20. ANTIBODY IDENTIFICATION BETH H. SHAZ, MD 21. DIRECT ANTIGLOBULIN TEST BETH H. SHAZ, MD b. Blood groups 22. ABO AND H BLOOD GROUP SYSTEMS BETH H. SHAZ, MD 23. RH BLOOD GROUP SYSTEM BETH H. SHAZ, MD 24. KELL AND KIDD BLOOD GROUP SYSTEMS BETH H. SHAZ, MD 25. MNS AND DUFFY BLOOD GROUP SYSTEMS BETH H. SHAZ, MD JOHN D. ROBACK, MD, PhD 26. LEWIS,I , AND P BLOOD GROUP SYSTEMS BETH H. SHAZ, MD 27. OTHER BLOOD GROUP SYSTEMS, COLLECTIONS, AND ANTIGENS BETH H. SHAZ, MD c. Blood products 28. RED BLOOD CELLS AND RELATED PRODUCTS CHRISTOPHER D. HILLYER, MD 29. PLASMA PRODUCTS CASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD 30. PLATELET PRODUCTS BETH H. SHAZ, MD 31. CRYOPRECIPITATE BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 32. GRANULOCYTE PRODUCTS CHRISTOPHER D. HILLYER, MD AND LAWRENCE B. FIALCOW, DO 33. ALBUMIN AND RELATED PRODUCTS ANNE M. WINKLER, MD AND BETH H. SHAZ, MD 34. HUMAN IMMUNOGLOBULIN PREPARATIONS BETH H. SHAZ, MD 35. RH IMMUNE GLOBULIN BETH H. SHAZ, MD d.Product modifications 36. IRRADIATION OF BLOOD PRODUCTS BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 37. LEUKOREDUCTION OF BLOOD PRODUCTS JAMES C. ZIMRING, MD, PhD 38. CMV- SAFE BLOOD PRODUCTS JOHN D. ROBACK, MD, PhD 39. FROZEN BLOOD PRODUCTS CASSSANDRA D. JOSEPHSON, MD and BETH H. SHAZ, MD 40. WASHED BLOOD PRODUCTS CASSSANDRA D. JOSEPHSON, MD and BETH H. SHAZ, MD 41. VOLUME REDUCED BLOOD PRODUCTS CASSSANDRA D. JOSEPHSON, MD e. Specific clinical settings 42. NEONATAL AND PEDIATRIC TRANSFUSION MEDICINE JEANNE E. HENDRICKSON, MD AND CASSSANDRA D. JOSEPHSON, MD 43. PERINATAL TRANSFUSION MEDICINE BETH H. SHAZ, MD 44. AUTOIMMUNE HEMOLYTIC ANEMIAS BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 45. TRANSFUSION MANAGEMENT IN PATIENTS WITH HEMOGLOBINOPATHIES BETH H. SHAZ, MD 46. TRANSFUSION OF PATIENTS UNDERGOING HPC AND SOLID ORGAN TRANSPLANTATION JEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD 47. TRANSFUSION OF HIV POSITIVE PATIENTS JEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD 48. TRANSFUSION MANAGEMENT IN PATIENTS WHO REFUSE BLOOD TRANSFUSION JEANNE E. HENDRICKSON, MD AND JOHN D. ROBACK, MD, PhD 49. PLATELET TRANSFUSION REFRACTORY PATIENTS JEANNE E. HENDRICKSON, MD and JOHN D. ROBACK, MD, PhD 50. MASSIVE TRANSFUSION BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 51. PERIOPERATIVE BLOOD MANAGEMENT BETH H. SHAZ, MD f. Transfusion reactions 52. ADVERSE EVENTS AND OUTCOMES FOLLOWING TRANSFUSION: AN OVERVIEW CASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD 53. FEBRILE NON-HEMOLYTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD 54. ALLERGIC, ANAPHYLACTOID AND ANAPHYLATIC REACTIONS BETH H. SHAZ, MD 55. ACUTE HEMOLYTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD and CHRISTOPHER D. HILLYER, MD 56. DELAYED HEMOLYTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD 57. TRANSFUSION ASSOCIATED CIRCULATORY OVERLOAD JEANNE E. HENDRICKSON, MD and CHRISTOPHER D. HILLYER, MD 58. TRANSFUSION RELATED ACUTE LUNG INJURY JEANNE E. HENDRICKSON, MD and CHRISTOPHER D. HILLYER, MD 59. SEPTIC TRANSFUSION REACTIONS CASSSANDRA D. JOSEPHSON, MD 60. METABOLIC, HYPOTENSIVE AND OTHER ACUTE REACTIONS AND COMPLICATIONS BETH H. SHAZ, MD 61. POST TRANSFUSION PURPURA ALFRED J. GRINDON 62. TRANSFUSION ASSOCIATED GRAFT VERSUS HOST DISEASE BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 63. MICROCHIMERISM BETH H. SHAZ, MD and CHRISTOPHER D. HILLYER, MD 64. TRANSFUSION RELATED IMMUNOMODULATION JAMES C. ZIMRING, MD, PhD 65. IRON OVERLOAD CASSSANDRA D. JOSEPHSON, MD 66. TRANSFUSION TRANSMITTED DISEASES BETH H. SHAZ, MD g. Therapeutic apheresis and phlebotomy 67. OVERVIEW TO THERAPEUTIC APHERESIS BETH H. SHAZ, MD 68. THERAPEUTIC PLASMA EXCHANGE BETH H. SHAZ, MD 69. THERAPEUTIC ERYTHROCYTAPHERESIS BETH H. SHAZ, MD 70. THERAPEUTIC THROMBOCYTAPHERESIS BETH H. SHAZ, MD 71. THERAPEUTIC LEUKOCYTAPHERESIS BETH H. SHAZ, MD 72. EXTRACORPOREAL PHOTOPHERESIS MARY DORROW, MD JEANNE E. HENDRICKSON, MD, and JOHN D. ROBACK, MD, PhD 73. LDL APHERESIS BETH H. SHAZ, MD 74. IMMUNOABSORPTION BETH H. SHAZ, MD 75. THERAPEUTIC PHLEBOTOMY LAWRENCE B. FIALCOW, DO and BETH H. SHAZ, MD h. Cellular therapy and tissue banking 76. HPC PRODUCTS JOHN D. ROBACK, MD, PhD and ELLIE HAMILTON 77. TISSUE BANKING in the HOSPITAL SETTING CASSSANDRA D. JOSEPHSON, MD II. Coagulation A. Introduction 78. AN OVERVIEW OF THE COAGULATION SYSTEM THOMAS C. ABSHIRE, MD and SHAWN JOBE, MD, PhD B. Clinical coagulation 79. APPROACH TO THE BLEEDING PATIENT THOMAS C. ABSHIRE, MD a. Neonatal thrombocytopenia 80. CONGENITAL THROMBOCYTOPENIA SHAWN JOBE, MD, PhD 81. NEONATAL ALLOIMMUNE THROMBOCYTOPENIA CAROLYN BENNETT, MD 82. ACQUIRED NEONATAL THROMBOCYTOPENIA CAROLYN BENNETT, MD b. inherited platelet function disorders 83. BERNARD-SOULIER SYNDROME AND OTHER GPIB-IX-V RELATED RECEPTOR DEFECTS SHAWN JOBE, MD, PhD 84. GLANZMANN'S THROMBOCYTOPENIA SHAWN JOBE, MD, PhD 85. PLATELET STORAGE GRANULE DEFECTS SHAWN JOBE, MD, PhD 86. FAILURE TO RELEASE AND ASPIRIN-LIKE DEFECTS SHAWN JOBE, MD, PhD c. Immune thrombocytopenia 87. ACUTE (CHILDHOOD) IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 88. CHRONIC IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 89. DRUG INDUCED THROMBOCYTOPENIA CAROLYN BENNETT, MD 90. HEPARIN INDUCED THROMBOCYTOPENIA CHRISTINE KEMPTON, MD 91. AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME MICHAEL BRIONES, DO d. Immune mediated coagulopathies 92. HEMOLYTIC UREMIC SYNDROME MICHAEL BRIONES, DO 93. THROMBOTIC THROMBOCYTOPENIC PURPURA CHRISTINE KEMPTON, MD 94. ANTIPHOSPHOLIPID ANTIBODY SYNDROME MICHAEL BRIONES, DO e. congenital bleeding disorders 95. VON WILLEBRAND DISEASE THOMAS C. ABSHIRE, MD 96. HEMOPHILIA A AMY DUNN, MD 97. HEMOPHILIA B AMY DUNN, MD 98. CONGENITAL DISORDERS OF FIBRINOGEN SHANNON MEEKS, MD 99. FACTOR XIII, D á2-ANTIPLASMIN, AND PLASMINOGEN ACTIVATOR INHIBITOR-1 DEFICIENCIES SHANNON MEEKS, MD 100. FACTOR XI DEFICIENCY THOMAS C. ABSHIRE, MD 101. FACTOR VII DEFICIENCY SHANNON MEEKS, MD 102. FACTOR II, FACTOR V, AND FACTOR X DEFICIENCIES SHANNON MEEKS, MD f. acquired bleeding disorders 103. BLEEDING DISORDERS IN PREGNANCY CHRISTINE KEMPTON, MD 104. VASCULAR BLEEDING DISORDERS MICHAEL BRIONES, DO 105. BLEEDING RISKS WITH LIVER DISEASE THOMAS C. ABSHIRE, MD 106. BLEEDING RISKS WITH VITAMIN K DEFICIENCY THOMAS C. ABSHIRE, MD 107. BLEEDING RISKS WITH CARDIAC DISEASE THOMAS C. ABSHIRE, MD 108. BLEEDING RISKS WITH RENAL DISEASE THOMAS C. ABSHIRE, MD 109. BLEEDING IN CANCER MICHAEL BRIONES, DO 110. DISSEMINATED INTRAVASCULAR COAGULOPATHY AMY DUNN, MD 111. ACQUIRED COAGULATION FACTOR INHIBITORS CHRISTINE KEMPTON, MD C. Laboratory testing of coagulation a. Introduction 112. INTRODUCTION TO COAGULATION TESTING JAMES C. ZIMRING, MD, PhD b. Screening tests 113. PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME JAMES C. ZIMRING, MD, PhD 114. PLATELET COUNT JAMES C. ZIMRING, MD, PhD 115. GLOBAL TESTS FOR PRIMARY HEMOSTASIS CONNIE H. MILLER Ph.D. c. Laboraty assessment of platelet disorders 116. PLATELET AGGREGATION STUDIES CONNIE H. MILLER Ph.D. 117. LABORATORY DIAGNOSIS OF GENETIC PLATELET FUNCTION DEFECTS CONNIE H. MILLER Ph.D. 118. LABORATORY DIAGNOSIS OF ACQUIRED PLATELET FUNCTION DEFECTS CONNIE H. MILLER Ph.D. 119. LABORATORY DIAGNOSIS IMMUNE THROMBOCYTOPENIC PURPURA CAROLYN BENNETT, MD 120. ADAMTS 13 ASSAYS CHRISTINE KEMPTON, MD 121. LABORATORY TESTING FOR HEPARIN INDUCED THROMBOCYTOPENIA ANNE M. WINKLER, MD AND JAMES C. ZIMRING, MD, PHD d. Laboratoy assessment of VWD 122. MOLECULAR BIOLOGY OF VON WILLEBRAND DISEASE CONNIE H. MILLER Ph.D. 123. DIAGNOSIS OF INHERITED VON WILLEBRAND DISEASE Connie H. Miller Ph.D. 124. LABORATORY DIAGNOSIS OF ACQUIRED VWD CONNIE H. MILLER Ph.D. 125. LABORATORY ASSESSMENT OF TREATMENT OF VWD CONNIE H. MILLER Ph.D. e. Laboratoy assessment of coagulation factor disorders 126. SPECIFIC FACTOR ASSAYS CONNIE H. MILLER Ph.D. 127. MIXING STUDIES CONNIE H. MILLER Ph.D. 128. SPECIFIC FACTOR INHIBITORS Connie H. Miller Ph.D. f. Laboratoy assessment of fibrinogen and fibrinolysis 129. LABORATORY DIAGNOSIS OF DYSFIBRINOGENEMIA AND AFIBRINOGENEMIA THOMAS C. ABSHIRE, MD 130. LABORATORY ASSESSMENT OF FIBRINOLYSIS THOMAS C. ABSHIRE, MD g. Tests for hypercoagulable state 131. GENERAL OVERVIEW OF THE HYPERCOAGULABLE STATE MICHAEL BRIONES, DO 132. ANTITHROMBIN TESTING JAMES C. ZIMRING, MD, PhD 133. PROTEINS C, S, AND Z JAMES C. ZIMRING, MD, PhD 134. ACTIVATED PROTEIN C RESISTANCE AND FACTOR V LEIDEN ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 135. PROTHROMBIN GENE MUTATION ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 136. HYPERHOMOCYSTENEMIA JAMES C. ZIMRING, MD, PhD 137. LUPUS ANTICOAGULANT AND ANTIPHOSPHOLIPID ANTIBODIES MICHAEL BRIONES, DO 138. LIPOPROTEIN (A) ANNE M. WINKLER MD and JAMES C. ZIMRING, MD, PhD 139. FACTOR LEVEL ABNORMALITIES ASSOCIATED WITH THROMBOSIS JAMES C. ZIMRING, MD, PhD h. Tests for activation of the coagulation system 140. LABORATORY MANAGEMENT OF DIC THOMAS C. ABSHIRE, MD i. Laboratoy support for anticoagulation 141. HEPARIN MONITORING ANNE WINKLER MD AND JAMES C. ZIMRING, MD, PhD 142. WARFARIN MONITORING ANNE M. WINKLER M.D. D. Coagulation factor products 143. PROTHROMBIN COMPLEX CONCENTRATES CHRISTINE KEMPTON, MD 144. VON WILLEBRAND FACTOR PRODUCTS THOMAS C. ABSHIRE, MD 145. FACTOR VIII CONCENTRATES AMY DUNN, MD 146. FACTOR IX CONCENTRATES AMY DUNN, MD 147. FACTOR VII CONCENTRATE CHRISTINE KEMPTON, MD 148. ANTITHROMBIN PRODUCTS MICHAEL BRIONES, DO 149. PROTEIN C PRODUCTS MICHAEL BRIONES, DO

Details

No. of pages:: 1014

Language:: English

Copyright:: © Elsevier Science 2013

Published:: 11th June 2013

Imprint:: Elsevier Science

eBook ISBN:: 9780123977885

Paperback ISBN:: 9780123971647

About the Editor

Beth Shaz

Beth H. Shaz, MD, is Chief Medical and Scientific Officer, Executive Vice President at New York Blood Center, and Adjunct Assistant Professor, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University. Beth is responsible for all medical and scientific activities throughout the NYBC network, which includes Rhode Island Blood Center, Innovative Blood Resources (Memorial Blood Center and Nebraska Blood Center), Community Blood Center of Greater Kansas City, and Blood Bank of Delmarva. Medical activities comprise of hemophilia services, clinical apheresis services, perioperative autologous transfusion services, cellular therapy, medical education, medical consultation, transfusion services, bone marrow donor recruitment, and donor management. Scientific activities include basic science at the Lindsey F. Kimball Research Institute and Comprehensive Cell Solutions (CCS), which contains translational and clinical research. NYBC’s scientific and medical activities focus on transfusion medicine, cell therapy, regenerative medicine, infectious disease, hematology, and personalized medicine. Beth is an editor of ten books in transfusion medicine, author of over 130 articles pertaining to transfusion medicine. She is an associate editor of TRANSFUSION and on the editorial board of BLOOD. Previously, she was an Associate Professor at Emory University School of Medicine and director of the transfusion service at Grady Memorial Hospital. Also, she was an instructor at Harvard Medical School and associate director of the transfusion service at Beth Israel Deaconess Medical Center in Boston. Beth received her MD with research distinction from the University of Michigan and BS in chemical engineering with distinction from Cornell University. She completed a general surgery internship at Georgetown University, an anatomic & clinical pathology residency at Beth Israel Deaconess Medical Center, and a transfusion medicine fellowship at Harvard Medical School.

Affiliations and Expertise

Chief Medical and Scientific Officer and Executive Vice President, New York Blood Center, New York, New York, USA Adjunct Assistant Professor, Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA

Christopher Hillyer

Christopher D. Hillyer, MD, is President and CEO of New York Blood Center and Professor, Department of Medicine, Weill Cornell Medical College, New York, NY. Previously, he was the tenured, endowed Distinguished Service Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine and served as director of the Emory Center for Transfusion and Cellular Therapies with responsibility for all aspects of clinical and academic transfusion medicine at Emory’s seven principle hospitals. Dr. Hillyer is an editor of twelve textbooks in transfusion medicine, author of over 160 articles pertaining to transfusion, human immunodeficiency virus, and herpes viruses, most notably cytomegalovirus. Nationally recognized as an expert in hematology and blood transfusion, Dr. Hillyer is also a past-president, board of directors of AABB and a former trustee of the National Blood Foundation. Dr. Hillyer has been awarded many million dollars in research funding from the National Institutes of Health, the Centers for Disease Control and Prevention and other agencies. He was an associate editor of Transfusion and serves on several other editorial boards. Dr. Hillyer was formally recognized for his work in Africa as part of the AABB/Emory cooperative agreement from the President’s Emergency Plan For AIDS Relief (PEPFAR), and is a recipient of two Tiffany Awards from the American Red Cross where he also served as a medical director and a member of their national Medical Advisory Board. He also received the 2014 Emily Cooley Award from AABB for his “significant commitment and contributions to the field of transfusion medicine through extensive teaching, mentoring and professional leadership, and the countless clinical, scientific and innovative resource materials he has created to educate others”. He is a co-founder of Transfusion & Transplantation Technologies, Inc (3Ti) and holds over 20 patents or patents pending. Dr. Hillyer is board certified in transfusion medicine, hematology, medical oncology and internal medicine. He received his BS from Trinity College, and his MD from the University of Rochester School of Medicine, with postgraduate training and fellowships in hematology-oncology, transfusion medicine and bone marrow transplantation at Tufts-New England Medical Center.

Affiliations and Expertise

President and Chief Executive Officer, New York Blood Center, New York, New York, USA Professor, Department of Medicine, Weill Cornell Medical College, New York, New York, USA

Reviews

"This book truly covers both hemostasis and transfusion medicine and bridges seamlessly between the disciplines, laboratory science, diagnosis (including clinical features), and medical treatment...Each chapter is so well contained and informative, it is like a tempting one-bite appetizer suitable for measured ingestion according to a reader's appetite for and ability to retain new information."--Doody.com, October 4, 2013
"Shaz, Hillyer, Roshal, and Abrams…provide clinical and laboratory information in transfusion medicine and hemostasis for all physicians and allied health professionals who order and administer blood components and specialized factors for hemostatic abnormalities in patients, as well as those who consult and care for these patients."--Reference and Research Book News, August 2013

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