Transfer Factor

Transfer Factor

Basic Properties and Clinical Applications

1st Edition - January 1, 1976

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  • Editors: Michael S. Ascher, A. Arthur Gottlieb, Charles H. Kirkpatrick
  • eBook ISBN: 9781483216157

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Transfer Factor: Basic Properties and Clinical Applications covers papers about transfer factor. The book presents papers on the in vitro studies of transfer factor; the characterization of transfer factor; and the animal models of transfer factor. The text also includes articles on the use of transfer factor in infectious and neoplastic diseases and transfer factor therapy. Examples of papers on transfer factor therapy include the role of transfer factor in the treatment of lymphoma cutis in Wiskott-Aldrich syndrome, transfer factor immunotherapy of rheumatoid arthritis, and transfer factor therapy in a patient with an isolated T-cell deficiency. Immunologists, pathologists, oncologists, microbiologists and people involved in the study of infectious diseases will find the book invaluable.

Table of Contents

  • Contents




    Section I. In Vitro Studies of Transfer Factor I

    In Vitro Properties of Leukocyte Dialysates Containing Transfer Factor: Micro Method and Recent Findings

    Specificity of Transfer Factor Action on Lymphocyte Transformation

    In Vitro Comparison of TFDM Obtained from Skin Test Positive and Negative Individuals

    Transfer Factor: In Vitro Effects on Lymphocyte Transformation

    Augmentation of Lymphocyte Transformation by Dialysable Transfer Factor

    Leukocyte Dialysates Require Precommitted, Antigen-Reactive Cells to Augment Lymphocyte Proliferation

    Experimental Studies of Transfer Factor

    Specific and Nonspecific Effects of Transfer Factor—Dialyzable Leukocyte Extracts

    In Vitro Characterization of the Target Cell for Transfer Factor—Dialyzable Leukocyte Extracts

    Section II. In Vitro Studies of Transfer Factor II

    Acquisition of Mixed Cell Migration Reactivity by Actively Sensitized and Transfer-Factor Treated Rhesus Monkeys

    In Vitro Assay for the Transfer Factor Using Direct Migration Inhibition

    In Vitro Assay for Transfer Factor by Means of Leukocyte Migration Test (LMT)

    Potentiating Effect of Transfer Factor upon Macrophage Migration Inhibition In Vitro

    Effects of Dialyzable Transfer Factor on Accumulation of Cyclic Nucleotides by Leukocytes

    Studies with In Vitro Produced Transfer Factor

    Guinea Pig "Transfer Factor" In Vitro: Physico-Chemical Properties and Partial Purification

    In Vitro Transfer of Coccidioidin and Histoplasmin Sensitivity to "Nonsensitive" Leukocytes Utilizing Whole Cell Lysates

    Coccidioidin Sensitive Humans: Evidence of Cross Reactivity in a Transfer System

    Production of Sheep Erythrocyte Rosette Forming Cells by Lymphocytes Cultured with Leucocyte Dialysates

    Section III. Characterization of Transfer Factor

    Identification of Hypoxanthine as the Major Component of Chromatographically Prepared Transfer Factor

    Transfer Factor—Some Biochemical Observations

    Quantitation of Transfer Factor

    Some Physico-Chemical and Biological Properties of a Transfer Factor Preparation and Its Clinical Application

    Use of Fluorescamine to Identify a Nonspecific Component of Human "Transfer Factor"

    Studies on the Biological and Chemical Nature of a Component in Transfer Factor with Immunologically Nonspecific Activity

    Demonstration of a Substance Chemically Similar to Human Transfer Factor in Lymphoid Cell Dialyzates from Several Animal Species

    Chromatograph y of Transfer Factor and Assay of Fractions In Vitro

    Fractionation of Rhesus Monkey Dialyzable KLH-Transfer Factor and the In Vitro Assay of Specific Biologic Activity Using the Indirect MIF Assay

    Bovine Transfer Factor: Isolation and Characteristics

    Biological Activity of Subfractions of Human Transfer Factor

    Fractionation of Transfer Factor with High Pressure Liquid Chromatography and E-Rosette Enhancing Activity of Various Fractions

    General Discussion

    Section IV. Animal Models of Transfer Factor

    Canine Transfer Factor

    "Non-Specific" Effects of Human Dialyzable Transfer Factor

    Transfer of Cellular Reactivity to 3 Nonhuman Primate Species with Human and Baboon Transfer Factor

    Prevention of Herpes Simplex Virus Type I Fatal Dissemination in Primates with Human Transfer Factor

    Transfer of Delayed Hypersensitivity to Mice with Human Immune Cell Extracts

    Human Transfer Factor in Guinea Pigs: Further Studies

    Human Transfer Factor in Guinea Pigs: Partial Purification of the Active Component

    Human Transfer Factor: Trials with an Assay in Guinea Pigs

    Correlation of In Vivo and In Vitro Activity of Guinea Pig Transfer Factor

    Section V. Transfer Factor in Infectious Diseases

    Transfer Factor Therapy of Chronic Aggressive Hepatitis

    Attempted Immunotherapy with Dialyzable Transfer Factor in Hepatitis B Carrier Chimpanzees: Induction of Delayed Hypersensitivity to Hepatitis B Surface Antigen (HBsAg)

    Transfer Factor Treatment of Viral Diseases in Milwaukee

    Preliminary Results on the Safety and Efficacy of Transfer Factor in Leprosy

    Clinical and Immunologie Results of Transfer Therapy in Coccidioidomycosis

    Combination Transfer Factor-Amphotericin B Therapy in a Case of Chronic Mucocutaneous Candidiasis: A Controlled Study

    Immunological Reconstitution of Chronic Mucocutaneous Candidiasis with Transfer Factor and Fetal Thymic Tissue

    Transfer Factor Therapy of Disseminated Histoplasmosis

    General Discussion

    Section VI. Transfer Factor in Neoplastic Diseases

    Transfer Factor Immunotherapy in Cancer

    An Unusual Metastatic Lesion in a Patient with Osteosarcoma Receiving Tumor Specific Transfer Factor

    Immunotherapy of Human Neoplasms with Transfer Factor

    Adjunctive Transfer Factor in Osteogenic Sarcoma: I. Clinical Implications of Chemotherapy and Immunotherapy

    Adjunctive Transfer Factor in Osteogenic Sarcoma: II. Methodology and Results of the Immunologic Studies

    Transfer Factor Therapy in Disseminated Neoplasms

    Clinical Trials with Transfer Factor

    Section VII. Transfer Factor Treatment

    The Role of Transfer Factor in the Treatment of Lymphoma Cutis in Wiskott-Aldrich Syndrome

    Is the Clinical Benefit from Transfer Factor in Rheumatoid Arthritis a Placebo Effect?

    The Effect of Chromatographically Purified Transfer Factor Component on Juvenile Rheumatoid Arthritis

    Transfer Factor Immunotherapy of Rheumatoid Arthritis

    Transfer Factor Therapy in a Patient with an Isolated T-Cell Deficiency

    Effects of Transfer Factor in Waldenstrom's Macroglobulinemia and Multiple Myeloma

    Treatment of a Child with Behcet's Syndrome with Transfer Factor

    Transfer Factor Treatment of Patients with Multiple Sclerosis II. Immunological Parameters in a Long-Term Clinical Trial

    Supplemental Papers

    Transfer of Protective Immunity to Friend Leukemia Virus by Cell Free Extracts of Immune Lymphoid Cells

    Leukapheresis of Cancer Patients for Adoptive Immunotherapy

    Transfer Factor and Skin Grafts

    On the Nature of Transfer Factor

    Investigations of the Transfer of Cellular Immunity in Animal Model System by the Transfer Factor

    Human "Transfer Factor" Activity in Guinea Pigs: Further Studies

    Lymphocyte Antigen Sensitivity as a Requirement for a Blastogenic Response to Transfer Factor

    Leishmania Enrietti Infections in Guinea Pigs and Transfer Factor Obtained from Convalescent yet Immune Animals

    Clinical Evaluation of the Effects of Transfer Factor on Multiple Sclerosis

    Section VIII. Keynote Address and Summation

    A Biochemist's View of the Mediators of Cellular Immunity, with Special Reference to Transfer Factor


    Subject Index

Product details

  • No. of pages: 780
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9781483216157

About the Editors

Michael S. Ascher

A. Arthur Gottlieb

Charles H. Kirkpatrick

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