Transduction Mechanisms in Cellular Signaling

1st Edition

Cell Signaling Collection


  • Edward A. Dennis
  • Ralph Bradshaw
  • Transduction Mechanisms in Cellular Signaling

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    Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences.

    Key Features

    • Articles written and edited by experts in the field
    • Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses
    • Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease


    Researchers and graduate students in Cell Biology, Molecular Biology, Biochemistry, Pharmacology, Molecular and Cellular Physiology, Pharmacy, and Biomedical Sciences.

    Table of Contents

    Volume two includes 183 chapters divided in 8 sections, including:

    Section A: Protein Phosphorylation

    56 Eukaryotic Kinomes: Genomics and Evolution of Protein Kinases

    57 Modular Protein Interaction Domains in Cellular Communication

    58 Structures of Serine/Threonine and Tyrosine Kinases

    59 Protein Tyrosine Kinase Receptor Signaling Overview

    60 Signaling by the Platelet-Derived Growth Factor Receptor Family

    61 The Epidermal Growth Factor Receptor Family

    62 Mechanisms and Functions of Eph Receptor Signaling

    63 Cytokine Receptor Signaling

    64 The Negative Regulation of JAK/STAT signaling

    65 Protein Kinase Inhibitors

    66 Integrin Signaling: Cell Migration, Proliferation, and Survival

    67 Downstream Signaling Pathways: Modular Interactions

    68 Non-Receptor Tyrosine Kinases in T Cell Antigen Receptor Function

    69 Receptor Tyrosine Kinase Signaling and Ubiquitination

    70 TGFb Signal Transduction

    71 Mitogen-Activated Protein Kinases

    72 Recognition of Phospho-Serine/Threonine Phosphorylated Proteins

    73 AMP-Activated Protein Kinase

    74 Principles of Kinase Regulation

    75 Calcium/Calmodulin-Dependent Protein Kinase II

    76 Glycogen Synthase Kinase 3

    77 The PIKK Family of Protein Kinases

    78 Histidine Kinases in Two-Component Signaling Pathways

    79 The EF2K/MHCK/TRPM7 Family of Atypical Protein Kinases

    80 The Leucine-Rich Repeat Receptor Protein Kinases of Arabidopsis thaliana

    81 Engineering Protein Kinases with Specificity for Unnatural Nucleotides and Inhibitors

    82 Clinical Applications of Kinase Inhibitors in Solid Tumors

    83 Ubiquitin-Mediated Regulation of Protein Kinases in NFκB Signaling

    84 Global Analysis of Phosphoregulatory Networks

    Section B: Protein Dephosphorylation

    85 Phosphatase Families Dephosphorylating Serine and Thre


    No. of pages:
    © 2011
    Academic Press
    Print ISBN:
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    About the authors

    Edward A. Dennis

    Edward A. Dennis is Distinguished Professor and former Chair of the Department of Chemistry and Biochemistry and Professor in the Department of Pharmacology in the School of Medicine at the University of California, San Diego. He is also Editor-in-Chief of the Journal of Lipid Research.

    Ralph Bradshaw

    Ralph A. Bradshaw is Professor Emeritus in the Department of Physiology and biophysics at the University of California, Irvine. Prior to that he was on the faculty of the Department of Biological Chemistry, Washington University School of Medicine in St. Louis, MO and was Professor and Chair of the Department of Biological Chemistry at the University of California, Irvine. From 2006 to 2015, he was a member of the Mass Spectrometry Facility and Professor of Pharmaceutical Chemistry at the University of California, San Francisco. He holds degrees from Colby College and Duke University and was a post-doctoral fellow at Indiana University and the University of Washington. He has served as president for FASEB, was the founding president of the Protein Society and was the treasurer of the American Society for Biochemistry and Molecular Biology. His research has focused on protein chemistry and proteomics, with emphasis on the structure and function of growth factors and their receptors, particularly nerve growth factor and fibroblast growth factor, and the involvement of receptor tyrosine kinases in cell signalling. He has also studied in the role of proteolytic processing and N-terminal modification in protein stability and turnover.