Tracer Methods for in Vivo Kinetics

Preface List of Symbols Chapter 1. Compartment Analysis: A Single Pool, Real or by Lumping Compartments or Pools Single-Pool Kinetics Estimation of Size and Turnover Rate of Two Pools Lumped as if One Excretion of Drugs Chapter 2. Compartment Analysis: Two-Pool Open Systems Multiple-Compartment Analysis Analysis of an Interchanging System Solution by Sampling Labeled Pool a Solution by Sampling Secondary Pool b Alone A Non Interchanging System Precautions and LimitationsChapter 3. Compartment Analysis: Three-Pool Open Systems A Completely Interchanging System Three Compartments Not Interchanging Completely Dissection of Rates Prediction of an Explicit Solution Prediction of Model Chapter 4. Compartment Analysis: Four or More Pools Four Pools Joining Subsystems Errors and False Inferences in Curve Analysis Analysis by Computer Chapter 5. Stochastic Analysis: The Stewart-Hamilton Equation Meaning of "Stochastic" The Stewart-Hamilton Equation The Stewart-Hamilton Equation When Rate Is for Mass Chapter 6. Stochastic Analysis: Rates of Production, Disposal, Secretion, and Conversion; Clearance Production (or Disposal) Rate of Individual Species Calculation of Local Output Rate Sampling Two Pools Rate Analysis by SA of Pooled Output Clearance Limitations Chapter 7. Stochastic Analysis: Mean Transit Time, Mass, Volume Concept of Mean Time Mean Sojourn Time All Input to Labeled Pool—Interrelated Formulas Chapter 8. Closed Systems, Cumulative Loss, Sinks Closed Systems Cumulative Loss Sink EffectChapter 9. Constant Infusion of Tracer Estimation of Rate without Compartment Analysis Compartment Analysis Clearance Chapter 10. Nonsteady State Meaning of Nonsteady State A Single Pool Complex Systems Chapter 11. Circulation Rate Measured by Tissue Saturation or Desaturation A Single Homogeneous Tissue A Nonhomogeneous Organ External Monitoring Chapter 12. Various Approximations from Curves Behavior of Primary Labeled Pool Iodide Transport Impulse Analysis Appendix I. Derivation of the Formula for Simple Exponential Loss Appendix II. Mathematical Solution of Multicompartment Models in Steady State A. An Open Three-Pool System B. An Open Four-Pool System C. Change in Equations When Channels or Pools are Eliminated D. Special Case, One-Way Flow, Equal-Sized Pools Appendix III. Relation of a Rate Ratio to Vertical Shift in tmax Appendix IV. Deconvolution by Numerical Sequence Approximation Appendix V. Some Definite Integrals and Derivatives References Index