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Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.
- Presents a complete review of molecular and cellar biology and immunology of Toxoplasma gondii combined with methods and resources for working with this pathogen
- Provides a single source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians and food scientists
- Covers recent advances in the genomics, related bioinformatics analysis, epigenomics, gene regulation, genetic manipulation and proteomics of T. gondii
- Details advances in the molecular and cellular biology and immunology of Toxoplasma, and in the epidemiology, diagnosis, treatment and prevention of toxoplasmosis
Parasitologists, Cell and molecular biologists, Immunologists, research Clinicians, neuroscientists, food scientists
- The History and Life Cycle of Toxoplasma gondii
2. The Ultrastructure of Toxoplasma gondii
3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
4. Human Toxoplasma Infection
5. Ocular Disease due to Toxoplasma gondii
6. Toxoplasmosis in Wild and Domestic Animals
7. Toxoplasma Animal Models and Therapeutics
8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition
9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism
10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics
11. The Apicoplast and Mitochondrion of Toxoplasma gondii
12. Calcium Storage and Homeostasis in Toxoplasma gondii
13. Signaling Networks in Toxoplasma gondii
14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)
15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy
16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)
17. Toxoplasma Host Effectors in Cell Interactions
18. Bradyzoite and Sexual Stage Development
19. Development and Application of Classical Genetics in Toxoplasma gondii
20. Genetic Manipulation of Toxoplasma gondii
21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii
23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences
25. Innate Immunity to Toxoplasma gondii
26. Adaptive Immunity and Genetics of the Host Immune Response
- No. of pages:
- © Academic Press 2020
- 20th March 2020
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.
Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, NY, USA
Kami Kim M.D. is Professor of Medicine (Division of Infectious Diseases), Professor of Pathology (Division of Parasitology and Tropical Medicine) and Professor of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, New York. Dr. Kim received her M.D. degree from Columbia College of Physicians and Surgeons in 1984. She trained in internal medicine at Columbia Presbyterian Medical Center and in infectious diseases at the University of California, San Francisco. Following her clinical training, she did a postdoctoral fellowship in the Department of Microbiology & Immunology at Stanford University School of Medicine, after which she joined the faculty at Einstein where she is currently a Professor of Medicine, Pathology and Microbiology and Immunology. Her laboratory research is focused upon understanding the pathogenesis of toxoplasmosis and malaria. Recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand the clinical impact of HIV co-infection upon cerebral malaria. She is also interested in understanding epigenetic and genetic factors that govern the host response to parasitic infections, opportunistic pathogens and tuberculosis. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America and an elected member of the Association for American Physcians and the American Society for Clinical Investigation.
Professor of Medicine, Pathology, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, NY, USA
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