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Toxoplasma Gondii - 3rd Edition - ISBN: 9780128150412, 9780128150429

Toxoplasma Gondii

3rd Edition

The Model Apicomplexan - Perspectives and Methods

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Editors: Louis Weiss Kami Kim
eBook ISBN: 9780128150429
Hardcover ISBN: 9780128150412
Imprint: Academic Press
Published Date: 20th March 2020
Page Count: 1242
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Description

Toxoplasma gondii: The Model Apicomplexan - Perspectives and Methods, Third Edition, reflects significant advances in the field in the last five years, including new information on the genomics, epigenomics and proteomics of T. gondii, along with a new understanding of the population biology and genetic diversity of this organism. This edition expands information on the effects of T. gondii on human psychiatric disease and new molecular techniques, such as CAS9/CSPR. T gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Key Features

  • Presents a complete review of molecular and cellar biology and immunology of Toxoplasma gondii combined with methods and resources for working with this pathogen
  • Provides a single source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians and food scientists
  • Covers recent advances in the genomics, related bioinformatics analysis, epigenomics, gene regulation, genetic manipulation and proteomics of T. gondii
  • Details advances in the molecular and cellular biology and immunology of Toxoplasma, and in the epidemiology, diagnosis, treatment and prevention of toxoplasmosis

Readership

Parasitologists, Cell and molecular biologists, Immunologists, research Clinicians, neuroscientists, food scientists

Table of Contents

  1. The History and Life Cycle of Toxoplasma gondii
    2. The Ultrastructure of Toxoplasma gondii
    3. Molecular Epidemiology and Population Structure of Toxoplasma gondii
    4. Human Toxoplasma Infection 
    5. Ocular Disease due to Toxoplasma gondii
    6. Toxoplasmosis in Wild and Domestic Animals
    7. Toxoplasma Animal Models and Therapeutics
    8. Biochemistry and Metabolism of Toxoplasma gondii: Lipids and Nutrient Acquisition
    9. Biochemistry and Metabolism of Toxoplasma gondii: Nucleotide and Amino Acid Metabolism
    10. Biochemistry and Metabolism of Toxoplasma gondii: Carbohydrates and Metabolomics
    11. The Apicoplast and Mitochondrion of Toxoplasma gondii
    12. Calcium Storage and Homeostasis in Toxoplasma gondii
    13. Signaling Networks in Toxoplasma gondii
    14. Toxoplasma Secretory Proteins (Micronemes, Rhoptries, Dense Granules)
    15. Toxoplasma Secretory Pathway, Intracellular Trafficking, and Autophagy
    16. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes (Need to include actin)
    17. Toxoplasma Host Effectors in Cell Interactions
    18. Bradyzoite and Sexual Stage Development
    19. Development and Application of Classical Genetics in Toxoplasma gondii
    20. Genetic Manipulation of Toxoplasma gondii
    21. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii
    22. Proteomics and Post Translational Protein Modifications in Toxoplasma gondii
    23. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae
    24. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioral Consequences
    25. Innate Immunity to Toxoplasma gondii
    26. Adaptive Immunity and Genetics of the Host Immune Response

Details

No. of pages:
1242
Language:
English
Copyright:
© Academic Press 2020
Published:
20th March 2020
Imprint:
Academic Press
eBook ISBN:
9780128150429
Hardcover ISBN:
9780128150412

About the Editors

Louis Weiss

Louis Weiss

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Affiliations and Expertise

Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, NY, USA

Kami Kim

Kami Kim

Kami Kim M.D. is Professor of Medicine (Division of Infectious Diseases), Professor of Pathology (Division of Parasitology and Tropical Medicine) and Professor of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, New York. Dr. Kim received her M.D. degree from Columbia College of Physicians and Surgeons in 1984. She trained in internal medicine at Columbia Presbyterian Medical Center and in infectious diseases at the University of California, San Francisco. Following her clinical training, she did a postdoctoral fellowship in the Department of Microbiology & Immunology at Stanford University School of Medicine, after which she joined the faculty at Einstein where she is currently a Professor of Medicine, Pathology and Microbiology and Immunology. Her laboratory research is focused upon understanding the pathogenesis of toxoplasmosis and malaria. Recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand the clinical impact of HIV co-infection upon cerebral malaria. She is also interested in understanding epigenetic and genetic factors that govern the host response to parasitic infections, opportunistic pathogens and tuberculosis. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America and an elected member of the Association for American Physcians and the American Society for Clinical Investigation.

Affiliations and Expertise

Professor of Medicine, Pathology, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University, NY, USA

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