Toxoplasma Gondii

2nd Edition

The Model Apicomplexan - Perspectives and Methods

Authors: Louis M. Weiss Kami Kim
Hardcover ISBN: 9780123964816
eBook ISBN: 9780123965363
Imprint: Academic Press
Published Date: 21st August 2013
Page Count: 1160
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Description

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

Key Features

  • Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen
  • Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis
  • Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists

Readership

Parasitologists, Cell and Molecular Biologists, Veterinarians and Veterinary Researchers, Neuroscientists, Research Clinicians, and Food Scientists

Table of Contents

Dedication

Preface to the First Edition

Preface to the Second Edition

List of Contributors

Chapter 1. The History and Life Cycle of Toxoplasma gondii

Abstract

Acknowledgements

1.1 Introduction

1.2 The Etiological Agent

1.3 Parasite Morphology and Life Cycle

1.4 Transmission

1.5 Toxoplasmosis in Humans

1.6 Toxoplasmosis in Other Animals

1.7 Diagnosis

1.8 Treatment

1.9 Prevention and Control

References

Chapter 2. The Ultrastructure of Toxoplasma gondii

Abstract

2.1 Invasive Stage Ultrastructure and Genesis

2.2 Coccidian Development in the Definitive Host

2.3 Development in the Intermediate Host

References

Chapter 3. Molecular Epidemiology and Population Structure of Toxoplasma gondii

Abstract

3.1 Introduction

3.2 Genetic Markers

3.3 Genotype Designation

3.4 Molecular Epidemiological and Population Studies

3.5 Factors Affecting Transmission and Genetic Exchange

3.6 Toxoplasma Genotype and Biological Characteristics

3.7 Toxoplasma gondii Genotype and Human Disease

References

Chapter 4. Human Toxoplasma Infection

Abstract

Acknowledgements

4.1 Clinical Manifestations and Course

4.2 Diagnosis of Infection with Toxoplasma gondii

4.3 Treatment

4.4 Prevention

4.5 Conclusions

References

Chapter 5. Ocular Disease due to Toxoplasma gondii

Abstract

Acknowledgments

5.1 Introduction

5.2 Historical Features of Ocular Toxoplasmosis

5.3 Epidemiology

5.4 The Mechanism of Tissue Damage in Ocular Toxoplasmosis

5.5 Host Factors in Ocular Toxoplasmosis

5.6 Parasite Factors in Ocular Infection

5.7 Animal Models

Details

No. of pages:
1160
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780123965363
Hardcover ISBN:
9780123964816

About the Author

Louis M. Weiss

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Affiliations and Expertise

Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.

Kami Kim

Kami Kim M.D. is Professor of Medicine (Division of Infectious Diseases), Professor of Pathology (Division of Parasitology and Tropical Medicine) and Professor of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, New York. Dr. Kim received her M.D. degree from Columbia College of Physicians and Surgeons in 1984. She trained in internal medicine at Columbia Presbyterian Medical Center and in infectious diseases at the University of California, San Francisco. Following her clinical training, she did a postdoctoral fellowship in the Department of Microbiology & Immunology at Stanford University School of Medicine, after which she joined the faculty at Einstein where she is currently a Professor of Medicine, Pathology and Microbiology and Immunology. Her laboratory research is focused upon understanding the pathogenesis of toxoplasmosis and malaria. Recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand the clinical impact of HIV co-infection upon cerebral malaria. She is also interested in understanding epigenetic and genetic factors that govern the host response to parasitic infections, opportunistic pathogens and tuberculosis. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America and an elected member of the Association for American Physcians and the American Society for Clinical Investigation.

Affiliations and Expertise

Professor of Medicine, Pathology, and Microbiology & Immunology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.

Reviews

"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." – Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio

"...a must have for anyone interested in the field of Toxoplasma research...the cornerstone of any aspiring protozoologist’s library...I love this book for its content, layout, and ease of finding detailed information…"--JAVMA,Toxoplasma Gondii, 2nd Edition