Mechanisms and Analytical Methods

1st Edition - January 1, 1961

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  • Editors: C. P. Stewart, A. Stolman
  • eBook ISBN: 9781483259789

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Toxicology: Mechanisms and Analytical Methods, Volume II provides an account of the general methods of chemical analysis available to the toxicologist, discussion of the principles on which they are based, and a survey of the material to which they are applied. The volume supplements the methods presented in the first volume. It provides specific examples of general procedures; considers the important groups of poisons; arranges the order of extraction from biological material; and discusses the methods for identifying and determining the members of each poison group. The book will be invaluable to toxicologists, clinical chemists, and biochemists.

Table of Contents

  • Contents

    Contributors to Volume II



    Contents of Volume I

    1. The Mode of Action of Poisons

    I. Introduction

    II. Enzyme Inhibition

    III. Factors which Influence Inhibition and Its Effects

    IV. Further Examples of Enzyme Inhibition; Antidotes

    V. Conclusion


    2. Gases, Vapors, Mists, and Dusts

    I. The Importance of Contaminated Atmosphere in Industrial Hygiene

    II. Biochemical Control of Exposure

    III. The Determination of Toxic Substances in the Atmosphere


    3. Identification and Estimation of Volatile Poisons

    I. Introduction

    II. Qualitative Tests

    III. Quantitative Procedures


    4. Ethyl Alcohol

    I. Pure Alcohol and Alcoholic Beverages

    II. "Normal" Alcohol

    III. Absorption of Alcohol

    IV. Distribution of Absorbed Alcohol

    V. Fate of Absorbed Alcohol

    VI. Pharmacological and Toxicological Effects

    VII. Determination of Alcohol in Body Materials; General Considerations

    VIII. Directions for Five Methods of Estimating Alcohol in Body Tissues and Fluids

    IX. Breath Alcohol Methods

    X. Medicolegal Interpretation of the Level of Blood Alcohol


    5. Barbiturates

    I. Isolation

    II. Identification

    III. Quantitative Determination of Barbiturates

    IV. Interpretation of Results

    V. Conclusion


    6. Acidic and Neutral Poisons (Other than Barbiturates)

    I. Introduction

    II. Isolation

    III. Purification

    IV. Identification

    V. Conclusion


    7. Alkaloids and Related Bases: Identification

    I. General Introduction

    II. Separation and Purification

    III. Identification and Determination

    IV. Biotransformations


    Appendix: The Discoveries of Some Alkaloids and Related Substances, Their Tests, and the Chronological Development of Toxicology


    8. Acids and Alkalies

    I. Mineral Acids

    II. Organic Acids

    III. Mineral Alkalies


    9. Chemical Tests for Metallic Poisons

    I. Reinsch Test

    II. Marsh-Berzelius Test

    III. Gutzeit Test

    IV. Dithizone Method

    V. Special Methods for Determination of Antimony, Barium, Chromium, Cobalt, Gold, Lithium, Manganese, Mercury, and Thallium


    10. Analysis of Residual Pesticides in Food

    I. Introduction

    II. Physical Methods

    III. Cleanup and Result of Chemical Changes in the Pesticide

    IV. Enzymatic Methods of Analysis

    V. The Importance of Metabolites

    VI. Nonspecific Methods for Chlorinated Organic Pesticides

    VII. Qualitative Tests for Rapid Identification of Chlorinated Pesticides

    VIII. Quantitative Determination of the Chloride Ion

    IX. Specific Methods for Chlorinated Pesticides

    X. The Cyclodiene Insecticides

    XI. Organic Phosphorus Pesticides

    XII. Analytical Methods for Organic Phosphorus Pesticides

    XIII. Carbamates

    XIV. Dithiocarbamates

    XV. Organic Pesticides Containing a CN Radical

    XVI. Organic Pesticides Containing a Thiocyanate Radical

    XVII. Determination of Dinitroaromatic Pesticides

    XVIII. Determination of Dinitroaromatic Compounds

    XIX. Miscellaneous Pesticides

    Appendix A: Partial List of Important Halogenated Compounds and Mixtures Used as Pesticides

    Appendix B: Some Important Organic Phosphorus Pesticides


    11. Poisonous Plants

    I. Introduction

    II. Chemical Ontogeny and Taxonomic Distribution

    III. Methods of Identification


    12. Radioactive Isotopes and Compounds

    I. Introduction

    II. Nuclear Energy and Radioactivity

    III. Interaction of Radiation with Matter

    IV. Sources of Exposure and Contact

    V. Radioactive Waste Disposal

    VI. Dosage Rate and Distribution

    VII. Methods of Detection and Measurement

    VIII. Pharmacology and Mechanism of Action

    IX. Handling and Disposal of Bodies and Tissues Containing Radioactive Materials

    X. Pathology; Acute and Chronic Effects of Various Organ Systems

    XL Medicolegal Interpretation


    13. Miscellaneous Determinations

    I. Hemoglobin Derivatives

    II. Halides

    III. Porphyrins

    IV. Glucuronic Acid


    14. The Treatment of Acute Poisoning

    I. Introduction

    II. Removal and Inactivation of the Poison

    III. Symptomatic Treatment

    IV. Plan of Treatment of a Case of Acute Poisoning

    V. Notes on Individual Poisons and Special Therapeutic Measures

    List of Poisons Discussed


    Subject Index

Product details

  • No. of pages: 938
  • Language: English
  • Copyright: © Academic Press 1961
  • Published: January 1, 1961
  • Imprint: Academic Press
  • eBook ISBN: 9781483259789

About the Editors

C. P. Stewart

A. Stolman

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