COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Toxicology - 1st Edition - ISBN: 9780128190920, 9780128190937


1st Edition

Oxidative Stress and Dietary Antioxidants

Editors: Vinood Patel Victor Preedy
Paperback ISBN: 9780128190920
eBook ISBN: 9780128190937
Imprint: Academic Press
Published Date: 18th November 2020
Page Count: 594
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs,  and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants.

Key Features

  • Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology
  • Explores the role of free radical mediated damage and toxicology
  • Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures


Toxicologists specifically in the field of mechanistic research; regulatory scientists that have proposed the use of antioxidants as a means to ameliorate the effects of toxicant exposures; Environmental scientists; Health Practitioners; Pathologists and Investigative biologists; Food scientists and technologists

Table of Contents


Part I: Toxicology and oxidative stress: General aspects, agricultural and industrial chemicals

1. Agrochemicals inhibiting mitochondrial respiration: Their effects on oxidative stress

Evangelia Flampouri

2. Nanoparticle toxicity and reactive species: An overview

Marcin Kruszewski and Agnieszka Grzelak

3. Oxidative stress status and industrial discharges

Regina Montero-Montoya, M. Rocı´o Lo´ pez-Vargas, and Myriam Arriaga-Alba

4. Terpene toxicity and oxidative stress

Hizlan Hincal Agus

5. Antioxidant status in pesticidesexposed agricultural workers

Ebtesam A. Abdel-Shafy

6. Antioxidant genes, the insecticide diazinon, and toxicity

Shokoufeh Hassani, Saeideh Momtaz, and Mohammad Abdollahi

7. Dimethoate organophosphate insecticide toxicity and the role of oxidative stress

Ays¸e Eken

8. Oxidative stress in paraquatinduced damage to nervous tissues

Dirleise Colle and Marcelo Farina

9. Glyphosate-based herbicides and oxidative stress

Marı´a Florencia Kronberg, Ariana Rossen, and Eliana Rosa Munarriz

10. NRF2 and paraquat-induced fatal redox stress

Jiaojiao Pang, Ying Zhang, Shuyi Wang, Qi Han, Ruru Sun, Changchang Xu, Yue Zheng, Feng Xu, Yuguo Chen, and Jun Ren

11. Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III), or nickel(II)

Sylwia Terpilowska

12. Oxidative stress toxicity effect of potential metal nanoparticles on human cells

Duduku Krishnaiah, Mohamed Khiari, Fahima Klibet, and Zine Kechrid

13. Oxidative stress and copper smelter workers

Ali Akbar Malekirad, Shokoufeh Hassani, and Mohammad Abdollahi

14. Aluminum toxicity and oxidative stress

Rafael Monteiro Fernandes, Luciana Guimara˜es Eiro´, Victo´ ria dos Santos Chemelo, Marı´a Olimpia Paz Alvarenga, and Rafael Rodrigues Lima

15. Methylmercury, oxidative stress, and neurodegeneration

Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Walessa Alana Braganc¸a Araga˜o, Bruna Puty, and Rafael Rodrigues Lima

16. Arsenic-induced oxidative stress in reproductive systems

Melike Erkan, Yasemin Aydin, Banu Orta Yilmaz, and Nebahat Yildizbayrak

17. The role of oxidative stress in fluoride toxicity

Giza Hellen Nonato Miranda, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Leidiane Alencar de Oliveira Lima, Bruna Puty, and Rafael Rodrigues Lima

18. Environmentally relevant level of aflatoxin B1 and the role of (non) oxidative immuno-/ neurodysregulation and toxicity

Jalil Mehrzad

19. A review on the oxidative effects of the fusariotoxins: Fumonisin B1 and fusaric acid

Thilona Arumugam, Terisha Ghazi, Naeem Sheik Abdul, and Anil A Chuturgoon

20. Mycotoxin exposure, oxidative stress, and lipid peroxidation

Miklo´sMezes, Melinda Kova < ´cs, and Andra´s Szabo

21. Toxicological effects of commonly used herbs and spices

Burcu Guldiken, Gizem Catalkaya, Gulay Ozkan, Fatma Duygu Ceylan, and Esra Capanoglu

22. Oxidative stress, Chinese herbals and toxicity: A focused review with examples

Cheng Zhang, Ning Wang, and Yibin Feng

23. Alcohol toxicity: The role of oxidative stress

Karadayian Analı´a Graciela, Bustamante Juanita, and Lores-Arnaiz Silvia

24. Radiation and oxidative stress

Ural KOC and Isa CAM

25. The impact of dimethyl sulfoxide on oxidative stress and cytotoxicity in various experimental models

Phiwayinkosi V. Dludla, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Tawanda M. Nyambuya, Sonia Silvestri, Patrick Orlando, Vuyolwethu Mxinwa, Johan Louw, and Luca Tiano

26. Statins, toxicity, and their adverse effects via oxidative imbalance

Arturo Anado´ n, Irma Ares, Marı´a Rosa Martı´nez-Larran˜ aga, and Marı´a Ara´nzazu Martı´nez

27. The toxicological impact of some agents on glutathione S-transferase and cholinesterase enzymes

Fikret Turkan and Mehmet Nuri Atalar

28. Oxidative stress due to 5 fluorouracil and dietary antioxidants

Kaı¨s Rtibi, Lamjed Marzouki, and Hichem Sebai

29. AZT oxidative damage in the liver

Armando Butanda-Ochoa, Carlos Alberto Ayhllon-Osorio, and Rolando Herna´ndez-Mun˜ oz

Part II: Antioxidants and toxicology: General aspects, agricultural and industrial chemicals

30. Effects of antioxidant nutrients on ionizing radiation-induced oxidative stress

Tiziana Cervelli, Giuseppina Basta, and Serena Del Turco

31. Linking metabolic profiling, resveratrol, the gut microbiota, and antioxidant potential

Gabriela Torres-Santiago, L. Gerardo Zepeda-Vallejo, and Jose Ivan Serrano-Contreras

32. Antioxidant and juc¸ara fruits (Euterpe edulis Martius): Potential applications in toxicology

Mayara Schulz, Luciano Valdemiro Gonzaga, Ana Carolina Oliveira Costa, and Roseane Fett

33. White Butterfly (Clerodendrum volubile) leaves and antioxidant potential in toxicity

Olorunfemi Raphael Molehin and Stephen Adeniyi Adefegha

34. Vernonia amygdalina leaf and antioxidant potential

Oluwaseun Ruth Alara and Nour Hamid Abdurahman

35. The antioxidant profile of two species belonging to the genus Leonurus. Potential applications in toxicity

Przemysław Sitarek, Tomasz Kowalczyk, Tomasz S´ liwinski, and Ewa Skała

36. Free radicals and coffee polyphenols: Potential applications in toxicity

Amel Saidi Merzouk and Hafida Merzouk

37. Amino acids ameliorate heavy metals-induced oxidative stress in male/female reproductive tissue

Mohammad Mehdi Ommati and Reza Heidari

38. Betaine, heavy metal protection, oxidative stress, and the liver

Mohammad Mehdi Ommati and Reza Heidari

39. An overview on the potential mechanisms of action of N-acetylL-cysteine in hexavalent chromium-induced toxicity

Iffet Ipek Bos¸gelmez

40. Soft electrophile inhibition of selenoenzymes in disease pathologies

Nicholas VC Ralston and Laura J Raymond

41. Selenium protection against cadmium and lead-induced oxidative stress

Bogdan Gabriel S¸ lencu

42. Protective effects of vitamin C against fluoride toxicity

Melike Erkan, Yasemin Aydin, Banu Orta Yilmaz, and Nebahat Yildizbayrak

43. Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity

M. Aylin Arici and Yesim Tuncok

44. Mycotoxin deoxynivalenol and oxidative stress: Role of silymarin and inulin protection

Mosaad A. Abdel-Wahhab and Aziza A. El-Nekeety

45. Curcumin, antioxidant activity, and paracetamol toxicity

Tejo J

46. Role of semisynthetic flavonoids on cytotoxic chemotherapy—Dual benefit to cancer patients?

Katrin Sak

47. Vernonia amygdalina (Del) as an antioxidant, aspirin toxicity, and oxidative stress

Quadri K. Alabi and Wale J. Adeyemi

48. Resveratrol and nicotine toxicity

Reham Z. Hamza, Tariq Al-Talhi, Adil A. Gobouri, Hatim Matuq M. Al-Yasi, Abd El-Aziz A. Diab and Samy M. El-Megharbel

49. The antioxidant effect of Peruvian maca (Lepidium meyenii)

Dulce E. Alarco´ n Yaquetto, Valeria M. Paz Aparicio, and Gustavo F. Gonzales

50. Aegle marmelos extract (L.) against CCL4 toxicity

Sanaa A. Ali, Hanan F. Aly, Nabaweya A. Ibrahim, and Doaa Abd Al-Hady

51. Horse mushroom (Agaricus arvensis Schaeff.) prevents oxidative stress in carbon tetrachloride toxicity

Abdulahad Dogan, Mert Ilhan, and Abdulhamit Battal

52. Recommended resources on toxicology: oxidative stress and dietary antioxidants

Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy


No. of pages:
© Academic Press 2021
18th November 2020
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editors

Vinood Patel

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, United Kingdom

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Ratings and Reviews