Oxidative Stress and Dietary Antioxidants

1st Edition - November 17, 2020

Write a review

  • Editors: Vinood Patel, Victor Preedy
  • Paperback ISBN: 9780128190920
  • eBook ISBN: 9780128190937

Purchase options

Purchase options
DRM-free (Mobi, PDF, EPub)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs,  and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants.

Key Features

  • Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology
  • Explores the role of free radical mediated damage and toxicology
  • Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures


Toxicologists specifically in the field of mechanistic research; regulatory scientists that have proposed the use of antioxidants as a means to ameliorate the effects of toxicant exposures; Environmental scientists; Health Practitioners; Pathologists and Investigative biologists; Food scientists and technologists

Table of Contents

  • Contributors

    Part I: Toxicology and oxidative stress: General aspects, agricultural and industrial chemicals

    1. Agrochemicals inhibiting mitochondrial respiration: Their effects on oxidative stress

    Evangelia Flampouri

    2. Nanoparticle toxicity and reactive species: An overview

    Marcin Kruszewski and Agnieszka Grzelak

    3. Oxidative stress status and industrial discharges

    Regina Montero-Montoya, M. Rocı´o Lo´ pez-Vargas, and Myriam Arriaga-Alba

    4. Terpene toxicity and oxidative stress

    Hizlan Hincal Agus

    5. Antioxidant status in pesticidesexposed agricultural workers

    Ebtesam A. Abdel-Shafy

    6. Antioxidant genes, the insecticide diazinon, and toxicity

    Shokoufeh Hassani, Saeideh Momtaz, and Mohammad Abdollahi

    7. Dimethoate organophosphate insecticide toxicity and the role of oxidative stress

    Ays¸e Eken

    8. Oxidative stress in paraquatinduced damage to nervous tissues

    Dirleise Colle and Marcelo Farina

    9. Glyphosate-based herbicides and oxidative stress

    Marı´a Florencia Kronberg, Ariana Rossen, and Eliana Rosa Munarriz

    10. NRF2 and paraquat-induced fatal redox stress

    Jiaojiao Pang, Ying Zhang, Shuyi Wang, Qi Han, Ruru Sun, Changchang Xu, Yue Zheng, Feng Xu, Yuguo Chen, and Jun Ren

    11. Pro- and antioxidant activity of chromium(III), iron(III), molybdenum(III), or nickel(II)

    Sylwia Terpilowska

    12. Oxidative stress toxicity effect of potential metal nanoparticles on human cells

    Duduku Krishnaiah, Mohamed Khiari, Fahima Klibet, and Zine Kechrid

    13. Oxidative stress and copper smelter workers

    Ali Akbar Malekirad, Shokoufeh Hassani, and Mohammad Abdollahi

    14. Aluminum toxicity and oxidative stress

    Rafael Monteiro Fernandes, Luciana Guimara˜es Eiro´, Victo´ ria dos Santos Chemelo, Marı´a Olimpia Paz Alvarenga, and Rafael Rodrigues Lima

    15. Methylmercury, oxidative stress, and neurodegeneration

    Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Walessa Alana Braganc¸a Araga˜o, Bruna Puty, and Rafael Rodrigues Lima

    16. Arsenic-induced oxidative stress in reproductive systems

    Melike Erkan, Yasemin Aydin, Banu Orta Yilmaz, and Nebahat Yildizbayrak

    17. The role of oxidative stress in fluoride toxicity

    Giza Hellen Nonato Miranda, Maria Karolina Martins Ferreira, Leonardo Oliveira Bittencourt, Leidiane Alencar de Oliveira Lima, Bruna Puty, and Rafael Rodrigues Lima

    18. Environmentally relevant level of aflatoxin B1 and the role of (non) oxidative immuno-/ neurodysregulation and toxicity

    Jalil Mehrzad

    19. A review on the oxidative effects of the fusariotoxins: Fumonisin B1 and fusaric acid

    Thilona Arumugam, Terisha Ghazi, Naeem Sheik Abdul, and Anil A Chuturgoon

    20. Mycotoxin exposure, oxidative stress, and lipid peroxidation

    Miklo´sMezes, Melinda Kova < ´cs, and Andra´s Szabo

    21. Toxicological effects of commonly used herbs and spices

    Burcu Guldiken, Gizem Catalkaya, Gulay Ozkan, Fatma Duygu Ceylan, and Esra Capanoglu

    22. Oxidative stress, Chinese herbals and toxicity: A focused review with examples

    Cheng Zhang, Ning Wang, and Yibin Feng

    23. Alcohol toxicity: The role of oxidative stress

    Karadayian Analı´a Graciela, Bustamante Juanita, and Lores-Arnaiz Silvia

    24. Radiation and oxidative stress

    Ural KOC and Isa CAM

    25. The impact of dimethyl sulfoxide on oxidative stress and cytotoxicity in various experimental models

    Phiwayinkosi V. Dludla, Bongani B. Nkambule, Sithandiwe E. Mazibuko-Mbeje, Tawanda M. Nyambuya, Sonia Silvestri, Patrick Orlando, Vuyolwethu Mxinwa, Johan Louw, and Luca Tiano

    26. Statins, toxicity, and their adverse effects via oxidative imbalance

    Arturo Anado´ n, Irma Ares, Marı´a Rosa Martı´nez-Larran˜ aga, and Marı´a Ara´nzazu Martı´nez

    27. The toxicological impact of some agents on glutathione S-transferase and cholinesterase enzymes

    Fikret Turkan and Mehmet Nuri Atalar

    28. Oxidative stress due to 5 fluorouracil and dietary antioxidants

    Kaı¨s Rtibi, Lamjed Marzouki, and Hichem Sebai

    29. AZT oxidative damage in the liver

    Armando Butanda-Ochoa, Carlos Alberto Ayhllon-Osorio, and Rolando Herna´ndez-Mun˜ oz

    Part II: Antioxidants and toxicology: General aspects, agricultural and industrial chemicals

    30. Effects of antioxidant nutrients on ionizing radiation-induced oxidative stress

    Tiziana Cervelli, Giuseppina Basta, and Serena Del Turco

    31. Linking metabolic profiling, resveratrol, the gut microbiota, and antioxidant potential

    Gabriela Torres-Santiago, L. Gerardo Zepeda-Vallejo, and Jose Ivan Serrano-Contreras

    32. Antioxidant and juc¸ara fruits (Euterpe edulis Martius): Potential applications in toxicology

    Mayara Schulz, Luciano Valdemiro Gonzaga, Ana Carolina Oliveira Costa, and Roseane Fett

    33. White Butterfly (Clerodendrum volubile) leaves and antioxidant potential in toxicity

    Olorunfemi Raphael Molehin and Stephen Adeniyi Adefegha

    34. Vernonia amygdalina leaf and antioxidant potential

    Oluwaseun Ruth Alara and Nour Hamid Abdurahman

    35. The antioxidant profile of two species belonging to the genus Leonurus. Potential applications in toxicity

    Przemysław Sitarek, Tomasz Kowalczyk, Tomasz S´ liwinski, and Ewa Skała

    36. Free radicals and coffee polyphenols: Potential applications in toxicity

    Amel Saidi Merzouk and Hafida Merzouk

    37. Amino acids ameliorate heavy metals-induced oxidative stress in male/female reproductive tissue

    Mohammad Mehdi Ommati and Reza Heidari

    38. Betaine, heavy metal protection, oxidative stress, and the liver

    Mohammad Mehdi Ommati and Reza Heidari

    39. An overview on the potential mechanisms of action of N-acetylL-cysteine in hexavalent chromium-induced toxicity

    Iffet Ipek Bos¸gelmez

    40. Soft electrophile inhibition of selenoenzymes in disease pathologies

    Nicholas VC Ralston and Laura J Raymond

    41. Selenium protection against cadmium and lead-induced oxidative stress

    Bogdan Gabriel S¸ lencu

    42. Protective effects of vitamin C against fluoride toxicity

    Melike Erkan, Yasemin Aydin, Banu Orta Yilmaz, and Nebahat Yildizbayrak

    43. Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity

    M. Aylin Arici and Yesim Tuncok

    44. Mycotoxin deoxynivalenol and oxidative stress: Role of silymarin and inulin protection

    Mosaad A. Abdel-Wahhab and Aziza A. El-Nekeety

    45. Curcumin, antioxidant activity, and paracetamol toxicity

    Tejo J

    46. Role of semisynthetic flavonoids on cytotoxic chemotherapy—Dual benefit to cancer patients?

    Katrin Sak

    47. Vernonia amygdalina (Del) as an antioxidant, aspirin toxicity, and oxidative stress

    Quadri K. Alabi and Wale J. Adeyemi

    48. Resveratrol and nicotine toxicity

    Reham Z. Hamza, Tariq Al-Talhi, Adil A. Gobouri, Hatim Matuq M. Al-Yasi, Abd El-Aziz A. Diab and Samy M. El-Megharbel

    49. The antioxidant effect of Peruvian maca (Lepidium meyenii)

    Dulce E. Alarco´ n Yaquetto, Valeria M. Paz Aparicio, and Gustavo F. Gonzales

    50. Aegle marmelos extract (L.) against CCL4 toxicity

    Sanaa A. Ali, Hanan F. Aly, Nabaweya A. Ibrahim, and Doaa Abd Al-Hady

    51. Horse mushroom (Agaricus arvensis Schaeff.) prevents oxidative stress in carbon tetrachloride toxicity

    Abdulahad Dogan, Mert Ilhan, and Abdulhamit Battal

    52. Recommended resources on toxicology: oxidative stress and dietary antioxidants

    Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy

Product details

  • No. of pages: 594
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: November 17, 2020
  • Imprint: Academic Press
  • Paperback ISBN: 9780128190920
  • eBook ISBN: 9780128190937

About the Editors

Vinood Patel

Vinood Patel
Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, United Kingdom

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is Emeritus Professor of Nutritional Biochemistry, at King’s College London and Professor of Clinical Biochemistry (Hon) at King’s College Hospital. He was the long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof. Preedy is a leading expert on the science of health and has a long-standing interest in dietary and plant-based components. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Emeritus Professor, King’s College London; Professor, King’s College Hospital, London, UK

Ratings and Reviews

Write a review

There are currently no reviews for "Toxicology"