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Toxicology - 1st Edition - ISBN: 9780128190920


1st Edition

Oxidative Stress and Dietary Antioxidants

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Editors: Vinood Patel Victor Preedy
Paperback ISBN: 9780128190920
Imprint: Academic Press
Published Date: 27th November 2020
Page Count: 560
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Toxicology: Oxidative Stress and Dietary Antioxidants examines the nature of oxidative stress as a consequence of exposure to toxins and how antioxidant approaches can mitigate the impact of toxicant exposures. Sections covers the basic biology of oxidative stress, from molecular biology, to physiological pathology, mechanisms of action of specific toxicants, metals and other chemicals/drugs,  and antioxidant approaches and therapies for toxic exposures. With contributions from an international group of experts, useful summary sections, a dictionary of terms, and applications to other areas of toxicology, this book is an informative, consolidated reference that helps bridge the interrelationship between toxicology, oxidative stress and antioxidants.

Key Features

  • Provides a novel collection of information linking both sides of redox biology (oxidants and antioxidants) and toxicology
  • Explores the role of free radical mediated damage and toxicology
  • Contains contributions from experts on toxicological science surrounding oxidative stress and on antioxidant approaches for reducing the impact of toxicant exposures


Toxicologists specifically in the field of mechanistic research; regulatory scientists that have proposed the use of antioxidants as a means to ameliorate the effects of toxicant exposures; Environmental scientists; Health Practitioners; Pathologists and Investigative biologists; Food scientists and technologists

Table of Contents


Part [1] Toxicology and Oxidative Stress

General Aspects, Agricultural and Industrial Chemicals

1. Agrochemicals inhibiting mitochondrial respiration: effects on oxidative stress

Evangelia Flampouri

2. Nanoparticle toxicity and reactive species: an overview

Marcin Kruszewski

3. Oxidative stress status and industrial discharges

Regina Dorinda Montero-Montoya

4. Terpene toxicity and oxidative stress

Hizlan Hincal Agus

5. Antioxidant status in pesticides-exposed agricultural workers

E A. Abdel-Shafy

6. Antioxidant genes, the insecticide diazinon and toxicity

Mohammad Abdollahi

7. Dimethoate organophosphate insecticide toxicity and the role of oxidative stress

Ayşe Eken

8. Oxidative stress in Paraquat-induced damage to nervous tissues

Dirleise Colle

9. Glyphosate-based herbicides and oxidative stress

Eliana Rosa Munarriz

10. Nrf2 and paraquat-induced fatal redox stress

Jun Ren

Minerals and Metals

11. Pro- and antioxidant activity of metals: chromium(III), iron(III), molybdenum(III) or nickel(II)

Sylwia Terpilowska

12. Nickel oxide nanoparticles, toxicity and reactive oxygen species


13. Oxidative stress and copper smelter workers

Ali Akbar Malekirad Sr.

14. Aluminium toxicity and oxidative stress

Rafael Rodrigues Lima

15. Methylmercury, oxidative stress and neurodegeneration

Rafael Rodrigues Lima

16. Arsenic induced oxidative stress in reproductive systems

Melike Erkan

17. Fluoride exposure and oxidative stress

Rafael Rodrigues Lima

Drugs, food derived, environment, chemicals and other agents

18. Environmentally relevant levels of flatoxin B1 and the role of (non)oxidative immuno/neurotoxicity

Jalil Mehrzad

19. A Review on the Oxidative Effects of the Fusariotoxins: Fumonisin B1 and Fusaric Acid

Anil A. Chuturgoon

20. Mycotoxin exposure, oxidative stress and lipid peroxidation

Miklós Mézes

21. Toxic aspects of herbs and spices

Esra Capanoglu

22. Oxidative stress, Chinese herbals and toxicity: a focused review with examples

Yibin Feng

23. Alcohol toxicity: the role of oxidative stress

Silvia Lores-Arnaiz

24. Radiation and oxidative stress

Ural Koc

25. Dimethyl sulfoxide toxicity and oxidative stress

Phiwayinkosi V. Dludla

26. Statins, toxicity and their adverse effects via oxidative imbalance

Arturo Anadón

27. The toxicological impact of some agents on metabolic enzymes selected glutathione S-transferase, acetylcholinesterase and butyrylcholinesterase enzymes

Fikret Türkan

28. Oxidative stress due to 5 fluorouracil and dietary antioxidants

Kais Rtibi

29. Zidovudine (AZT), liver cells and oxidative stress

Rolando Hernandez-Munoz

Part [2] Antioxidants and Toxicology

General Aspects, Agricultural and Industrial Chemicals

30. Effects of antioxidant nutrients on ionizing radiation-induced oxidative stress

Serena Del Turco

31. Linking metabolic profiling, resveratrol, the gut microbiota and antioxidant potential

Jose Ivan Serrano-Contreras

32. Antioxidant and jucara fruits (Euterpe edulis Martius): potential applications in toxicology

Mayara Schulz

33. White Butterfly (Clerodendrum volubile) leave and antioxidant potential in toxicity

Olorunfemi Raphael Molehin

34. Vernonia amygdalina leaves and antioxidant potential

Oluwaseun Ruth Alara

35. The antioxidant profile of two species belonging to the genus Leonurus: Potential applications in toxicity

Przemysław Sitarek

36. Free radicals, and coffee polyphenols: Potential applications in toxicity

Hafida Merzouk

Minerals and Metals

37. Amino acids ameliorate heavy metals-induced oxidative stress in male/female reproductive tissue

Reza Heidari

38. Betaine, heavy metal protection, oxidative stress and the liver

Reza Heidari

39. Antioxidant N-acetyl-l-cysteine in chromium protection

Iffet Ipek Bosgelmez

40. Soft Electrophile Inhibition of Selenoenzymes in Disease Pathologies.

Nicholas Ralston

41. Selenium protection against cadmium and lead induced oxidative stress

Bogdan Gabriel Slencu

42. Curcumin, cadmium toxicity and oxidative stress

Hyung Sik Kim

43. Protection of vitamin C against fluoride toxicity

Melike Erkan and banu Orta Yilmaz

Drugs, food derived, environment, chemicals and other agents

44. Mushroom related toxins, alpha-amanitin and usage of antioxidants: directions towards antioxidant capacity

M A Arici

45. Mycotoxin deoxynivalenol and silymarin and inulin protection: role of oxidative stress

Mosaad A Abdel-Wahhab

46. Curcumin, antioxidant activity and paracetamol toxicity

Tejo Jayadi

47. Role of semisynthetic flavonoids on cytotoxic chemotherapy – dual benefit to cancer patients?

Katrin Sak

48. Vernonia amygdalina (Del.) as a protectant, aspirin toxicity and oxidative stress

Quadri K. Alabi

49. Resveratrol and nicotine toxicity

Reham Zakaria Hamza

50. Lepidium meyenii (maca), 6-hydroxy dopamine (6-OHDA)-toxicity and oxidative stress

Gustavo F. Gonzales Sr.

51. Aegle marmelos extract (L.) against CCL4 toxicity

Sanaa Ahmed Ali

52. Horse mushroom (Agaricus arvensis Schaeff.) prevents oxidative stress in carbon tetrachloride toxicity

Abdulahad Dogan

53. Resources

Rajkumar Rajendram


No. of pages:
© Academic Press 2021
27th November 2020
Academic Press
Paperback ISBN:

About the Editors

Vinood Patel

Vinood Patel

Dr Vinood B. Patel BSc PhD FRSC is currently a Senior Lecturer in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the patho-physiology of liver disease. Other areas of interest include identifying new biomarkers that can be used for diagnosis and prognosis of liver disease, understanding mitochondrial oxidative stress in Alzheimers disease and gastrointestinal dysfunction in autism. Dr. Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His post-doctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr. Patel is a nationally and internationally recognized liver researcher and was involved in several NIH funded biomedical grants related to alcoholic liver disease. Dr. Patel has edited biomedical books in the area of nutrition and health prevention, autism, biomarkers, and has published over 150 articles and in 2014 he was elected as a Fellow to The Royal Society of Chemistry.

Affiliations and Expertise

Senior Lecturer, Clinical Biochemistry, University of Westminster, London, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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