Toxicology

Advances in Pharmacology and Therapeutics, Volume 9: Toxicology is a collection of papers that tackles advances in toxicological research in context of pharmacology. The text first covers reactive metabolites and their implications for toxicology. Next, the selection deals with the experimental and clinical correlations of behavioral toxicology. The text also tackles toxicology and pharmacology of topical application. The book will be of great use to researchers and practitioners of health related disciplines.

Introduction Dedication Reactive Metabolites and Their Implications for Toxicology Metabolic Activation of Chemicals to Reactive Electrophiles: An Overview DNA Binding and Polycyclic Hydrocarbon Carcinogenesis Environmental Chemicals Causing Cancer and Genetic Birth Defects: Mutagenicity Testing for Reactive Metabolites Biological Activity of Polycyclic Hydrocarbon Metabolites and the Bay Region Theory Stereoselective Metabolic Activation of Polycyclic Aromatic Hydrocarbons Metabolic Inactivation of Reactive Metabolites Factors Influencing DNA Damage and Its Repair with Cellular Implications for Toxicology New Aspects of Nitrosamine-Induced Carcinogenesis Tissue Specificity in Metabolic Activation Formation of Chemically Reactive Metabolites from Drugs Metabolic Activation of Aminostilbene Derivatives and Diethylstilbestrol Metabolic Activation of Chlorinated Ethylene Derivatives Carbenes and Free Radicals of Haloalkanes as Toxic Intermediates Concluding Remarks Behavioral Toxicology: Experimental and Clinical Correlations The Agenda of Behavioral Toxicology Duration of Exposure: An Important Variable in Behavioral Toxicology Changes in Performance, Personality and Subjective Well-Being as Indicators of Long-Term Exposure to Toxic Environments Neurophysiological Characteristics of the Action of Toxic Substances on the Organism Neurochemical Changes Associated With the Behavioral Toxicity of Organophosphate Compounds Approach to a Behavioral Screen in Toxicity Testing Alertness Impairing Substances and Transport and Occupational Safety: Laboratory Assessment of Hazard Toxicology and Pharmacology of Topical Applications Principles of Percutaneous Absorption Epidermal Response to Antihyperkeratotic Agents Toxicological and Pharmacological Aspects of Topical Agents in Relation to the Dermis Toxicological