Toxicology and Experimental Models

Toxicology and Experimental Models

Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981

1st Edition - January 1, 1982

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  • Editors: H. Yoshida, Y. Hagihara, S. Ebashi
  • eBook ISBN: 9781483148489

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Advances in Pharmacology and Therapeutics II, Volume 5: Toxicology and Experimental Models is the fifth of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into six parts, this book begins by elucidating the rational interpretation of species and strain differences in toxicity for the prediction of risk to man. Subsequent parts discuss the chemical interactions resulting in liver and kidney injury; the role of heme synthesis and degradation in predicting drug toxicity; and delayed toxic effects of pre- and perinatal drug exposure. Other chapters describe models of experimental peptic ulcers and therapeutic agents and models and quality control of laboratory animals.

Table of Contents

  • Introduction

    The Rational Interpretation of Species and Strain Differences in Toxicity for the Prediction of Risk to Man

    The rational interpretation of species and strain differences for the prediction of risk to man - Introduction

    The potential value of immunopathology in toxicity studies

    Lessons from studies in animals for the evaluation of human risk from teratogenic agents

    Genetic variability in man as a complicating factor in the extrapolation of toxicological data from animals

    The rational interpretation of species and strain differences in toxicity for the prediction of risk to man: Review and concluding remarks

    Chemical Interactions Resulting in Liver and Kidney Injury

    Ethanol potentiation of liver injury

    Potentiation of liver and kidney injury by ketones and ketogenic substances

    Biochemical mechanisms of acetaminophen (paracetamol) induced hepatic and renal toxicity

    The hepatotoxicity and nephrotoxicity of hexachlorobutadiene

    Modulation of nephrotoxicity by environmental chemicals

    Heme Synthesis and Degradation: Its Role in Predicting Drug Toxicity

    Heme synthesis and degradation: its role in predicting drug toxicity - Opening remarks

    Effects of drugs and chemicals on d-aminolevulinic acid synthase, the rate-limiting enzyme of heme synthesis

    Effects of drugs and metals on heme degradation by the heme oxygenase system

    Liver haem as a target for drug toxicity

    Toxic effects of metals on the synthesis and disposition of heme

    The heme biosynthetic pathway in the prediction of haloaromatic hydrocarbon toxicity

    Delayed Toxic Effects of Pre- and Perinatal Drug Exposure

    An overview on delayed toxic effects of pre- and perinatal drug exposure

    Improvements in the postnatal detection of central nervous system defects

    Maldevelopment of CNS induced by perinatal metabolic insults and possibilities of its regulation

    Altered postnatal development following intrauterine exposure to hormonally active chemicals

    Alcohol Intoxication and Withdrawal

    Alcohol intoxication and withdrawal: Introductory remarks

    The role of mitochondrial NADH reoxidation in the hepatic metabolism of ethanol: studies with perfused livers from ethanol and CCl4-treated rats

    Thanol and membrane cholesterol

    Suceptibility to ethanol of neurons in lateral vestibular, spinal trigeminal and lateral geniculate nuclei

    Dissociation of components of ethanol intoxication and tolerance

    Models of Experimental Peptic Ulcers and Therapeutic Agents

    Models of experimental peptic ulcers and therapeutic agents

    Possible roles of central catecholamines in regulation of gastric functions

    Duodenal ulcer and dopamine: new elements in pathogenesis and therapy

    Defensive mechanism in peptic ulcer and assessment of anti-ulcer agents

    Differential role of histamine in duodenal versus gastric experimental ulcer

    Can the mechanisms of aspirin-induced gastric mucosal injury be identified?

    Screening of anti-ulcer agents using experimental ulcer models

    Models and Quality Control of Laboratory Animals

    Introduction to models and quality control of laboratory animals

    Consideration of provision and characterization of animal models

    New animal models in pharmaceutical research

    Species variation in evaluation of safety of drugs in the developing animal

    Defined laboratory animals

    Quality control in diets - the attainable

    Problems and improvements in the development of good laboratory practice


Product details

  • No. of pages: 366
  • Language: English
  • Copyright: © Pergamon 1982
  • Published: January 1, 1982
  • Imprint: Pergamon
  • eBook ISBN: 9781483148489

About the Editors

H. Yoshida

Affiliations and Expertise

Osaka International University for Women, Osaka, Japan

Y. Hagihara

S. Ebashi

Affiliations and Expertise

National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan

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