Toxicology and Experimental Models - 1st Edition - ISBN: 9780080280257, 9781483148489

Toxicology and Experimental Models

1st Edition

Proceedings of the 8th International Congress of Pharmacology, Tokyo, 1981

Editors: H. Yoshida Y. Hagihara S. Ebashi
eBook ISBN: 9781483148489
Imprint: Pergamon
Published Date: 1st January 1982
Page Count: 366
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Description

Advances in Pharmacology and Therapeutics II, Volume 5: Toxicology and Experimental Models is the fifth of a six-volume compilation of the scientific papers of invited speakers of the Eighth International Congress of Pharmacology. Organized into six parts, this book begins by elucidating the rational interpretation of species and strain differences in toxicity for the prediction of risk to man. Subsequent parts discuss the chemical interactions resulting in liver and kidney injury; the role of heme synthesis and degradation in predicting drug toxicity; and delayed toxic effects of pre- and perinatal drug exposure. Other chapters describe models of experimental peptic ulcers and therapeutic agents and models and quality control of laboratory animals.

Table of Contents


Introduction

The Rational Interpretation of Species and Strain Differences in Toxicity for the Prediction of Risk to Man

The rational interpretation of species and strain differences for the prediction of risk to man - Introduction

The potential value of immunopathology in toxicity studies

Lessons from studies in animals for the evaluation of human risk from teratogenic agents

Genetic variability in man as a complicating factor in the extrapolation of toxicological data from animals

The rational interpretation of species and strain differences in toxicity for the prediction of risk to man: Review and concluding remarks

Chemical Interactions Resulting in Liver and Kidney Injury

Ethanol potentiation of liver injury

Potentiation of liver and kidney injury by ketones and ketogenic substances

Biochemical mechanisms of acetaminophen (paracetamol) induced hepatic and renal toxicity

The hepatotoxicity and nephrotoxicity of hexachlorobutadiene

Modulation of nephrotoxicity by environmental chemicals

Heme Synthesis and Degradation: Its Role in Predicting Drug Toxicity

Heme synthesis and degradation: its role in predicting drug toxicity - Opening remarks

Effects of drugs and chemicals on d-aminolevulinic acid synthase, the rate-limiting enzyme of heme synthesis

Effects of drugs and metals on heme degradation by the heme oxygenase system

Liver haem as a target for drug toxicity

Toxic effects of metals on the synthesis and disposition of heme

The heme biosynthetic pathway in the prediction of haloaromatic hydrocarbon toxicity

Delayed Toxic Effects of Pre- and Perinatal Drug Exposure

An overview on delayed toxic effects of pre- and perinatal drug exposure

Improvements in the postnatal detection of central nervous system defects

Maldevelopment of CNS induced by perinatal metabolic insults and possibilities of its regulation

Altered postnatal development following intrauterine exposure to hormonally active chemicals

Alcohol Intoxication and Withdrawal

Alcohol intoxication and withdrawal: Introductory remarks

The role of mitochondrial NADH reoxidation in the hepatic metabolism of ethanol: studies with perfused livers from ethanol and CCl4-treated rats

Thanol and membrane cholesterol

Suceptibility to ethanol of neurons in lateral vestibular, spinal trigeminal and lateral geniculate nuclei

Dissociation of components of ethanol intoxication and tolerance

Models of Experimental Peptic Ulcers and Therapeutic Agents

Models of experimental peptic ulcers and therapeutic agents

Possible roles of central catecholamines in regulation of gastric functions

Duodenal ulcer and dopamine: new elements in pathogenesis and therapy

Defensive mechanism in peptic ulcer and assessment of anti-ulcer agents

Differential role of histamine in duodenal versus gastric experimental ulcer

Can the mechanisms of aspirin-induced gastric mucosal injury be identified?

Screening of anti-ulcer agents using experimental ulcer models

Models and Quality Control of Laboratory Animals

Introduction to models and quality control of laboratory animals

Consideration of provision and characterization of animal models

New animal models in pharmaceutical research

Species variation in evaluation of safety of drugs in the developing animal

Defined laboratory animals

Quality control in diets - the attainable

Problems and improvements in the development of good laboratory practice

Index




Details

No. of pages:
366
Language:
English
Copyright:
© Pergamon 1982
Published:
Imprint:
Pergamon
eBook ISBN:
9781483148489

About the Editor

H. Yoshida

Affiliations and Expertise

Osaka International University for Women, Osaka, Japan

Y. Hagihara

S. Ebashi

Affiliations and Expertise

National Institute for Physiological Sciences, Myodaiji, Okazaki, Japan