Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

1st Edition - August 1, 2021

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  • Editor: Aristidis Tsatsakis
  • Paperback ISBN: 9780323852159
  • eBook ISBN: 9780323853583

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Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.

Key Features

  • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field
  • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease
  • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research


Researchers, industry professionals, and graduate students from various disciplines of toxicology. Physicians, public health professionals, specialists in bioinformatics, risk assessors, and regulatory agencies

Table of Contents

  • Part 1: Modern tools and concepts in toxicology testing
    1. Mixture toxicity evaluation in modern toxicology
    2. Alternative methods and their role in modern toxicology
    3. The exposome—a new paradigm for nonanimal toxicology and integrated risk assessment
    4. In silico toxicology, a robust approach for decision-making in the context of next-generation risk assessment
    5. Safety science in the 21st century—a scientific revolution in its making
    6. Chemobrain

    Part 2: Methods and toxicity models in toxicology
    7. "Predictive in silico toxicology." An update on modern approaches and a critical analysis of its strong and weak points
    8. Analytical strategies to study the gut microbiome in toxicology
    9. Behavioral endpoints in adult and developmental neurotoxicity: the case of organophosphate pesticides
    10. Nuclear factor erythroid 2-related factor 2-mediated antioxidant response as an indicator of oxidative stress
    11. The potential of complex in vitro models in pharmaceutical toxicology

    Part 3: New insights in risk assessment
    12. Health-based exposure limits and toxicology in pharmaceutical industry
    13. The hormetic dose response: implications for risk assessment
    14. Endocrine disruption and human health risk assessment in light of real-life risk simulation
    15. Toxicity data as the basis for acute and short-term emergency exposure guidance
    16. Renal mitochondria as sentinels for exposures to environmental toxicants and nephrotoxic drugs

    Part 4: Clinical biomarkers updates
    17. Updates on current biomarkers in toxicology
    18. The role of extracellular matrix in allergic contact dermatitis pathogenesis
    19. Review of current neurotoxicology issues
    20. Modern aspects of immunotoxicology
    21. Toxicology of neurodegenerative diseases
    22. Toxicogenetics—Pharmacogenetics: genetic variability profiling for xenobiotic response heterogeneity
    23. Current and emerging concepts of cardiotoxicity
    24. Metabolomics: diagnostic and therapeutic applications in clinical medicine and pharmacology
    25. Metabolomics methodology and workflow: challenges and future prospects
    26. Telomere length: associations with nutrients and xenobiotics

    Part 5: Epidemiology and public health toxicology issues
    27. Dismissing the use of P-values and statistical significance testing in scientific research: new methodological perspectives in toxicology and risk assessment
    28. Modern approaches for the assessment of human exposure to dietary mycotoxins
    29. Tobacco toxicity and regulatory science
    30. Dethroning the crown. From the kinetics and dynamics of COVID-19 diagnosis to the promising treatments
    31. Toxicology issues related to COVID-19 outbreak
    32. Risk assessment for heat stress during work and leisure

    Part 6: Pharmaceuticals and nutraceuticals toxicology updates
    33. Polyphenols: the hallmark of endothelial dysfunction combatants
    34. Effect of diet, pharmaceuticals, and environmental toxicants on gut microbiota imbalance and increased intestinal membrane permeability
    35. Hydrogen sulfide: a shifting paradigm
    36. Redox biomarkers in toxicology and nutrition: the social link
    37. Safety profile of plants and phytoconstituents used in traditional medicine worldwide

    Part 7: Toxicology of biomaterials and nanomaterials
    38. Epigenetic mechanisms in nanomaterial toxicity
    39. Predictive nanotoxicology: from nanotoxicity to nanosafety of select and commonly used nanomaterials
    40. The toxicological effects of titanium dioxide nanoparticles on marine microalgae
    41. Aquatic nanotoxicology: reference species and omics technologies
    Part 8: Special topics in toxicology
    42. Toxicity of arsenicals in diseases: friend or foe?
    43. Toxicity of psychedelic drugs
    44. Immunotoxicity of pesticides: current knowledge and perspectives
    45. Glyphosate-based herbicides: evidence of immune-endocrine alteration
    46. Ciguatera toxins: toxicity and food safety
    47. Cannabinoids and psychosis: current challenges of mechanistic toxicology
    48. Electronic cigarettes as a harm reduction concept for public health

Product details

  • No. of pages: 684
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: August 1, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323852159
  • eBook ISBN: 9780323853583

About the Editor

Aristidis Tsatsakis

Aristidis Tsatsakis is Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion. He has more than 1000 publications, including 700 in ISI journals and is extensively cited. He was EUROTOX President (2014–16) and still an Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow. He is Doctor Honoris Causa of the Mendeleev Moscow University, the Far East Federal University (FEFU), Vladivostok, and the Carol Davila in Bucharest. He is a Foreign Member of the National Academy of Sciences of Russia (FMRAS) and a Fellow of the Academy of Toxicological Sciences (FATS, United States). He is the creator, founder, and chief scientific officer of ToxPlus SA. He developed numerous biomarkers of exposure and of effects for the pesticide and chemical toxicology field, uncovering the mechanistic understanding of the mode of actions, adverse outcome pathways, and clinical affects. He is currently the Editor of Food Chemical Toxicology, Editor-in-Chief of Toxicology Reports, Guest Editor of four special issues in Toxicology Letters, Toxicology and Food and Chemical Toxicology journals, Guest Editor of the RIFM-Food and Chemical Toxicology issue, Associate Editor, and member of the Editorial Boards in several other ISI indexed journals. He has also been recognized as Highly Cited Researcher 2020 in the field of Pharmacology–Toxicology (Publons).

Affiliations and Expertise

Director, Department of Toxicology and Forensic Sciences, Medical School, University of Crete, University Hospital of Heraklion, Crete, Greece

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  • Toni S. Tue Nov 09 2021

    Toxicological Risk Assessment and multi-system health

    This is a brilliant book. I recommended if you are interest in learning about exposure to real-life pollutant mixtures.