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Toxicological Risk Assessment and Multi-System Health Impacts from Exposure - 1st Edition - ISBN: 9780323852159, 9780323853583

Toxicological Risk Assessment and Multi-System Health Impacts from Exposure

1st Edition

Editor: Aristidis Tsatsakis
Paperback ISBN: 9780323852159
eBook ISBN: 9780323853583
Imprint: Academic Press
Published Date: 1st August 2021
Page Count: 684
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Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment.

Key Features

• Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field
• Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease
• Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research


Researchers, industry professionals, and graduate students from various disciplines of toxicology. Physicians, public health professionals, specialists in bioinformatics, risk assessors, and regulatory agencies

Table of Contents

Part 1: Modern tools and concepts in toxicology testing
1. Mixture toxicity evaluation in modern toxicology
2. Alternative methods and their role in modern toxicology
3. The exposome—a new paradigm for nonanimal toxicology and integrated risk assessment
4. In silico toxicology, a robust approach for decision-making in the context of next-generation risk assessment
5. Safety science in the 21st century—a scientific revolution in its making
6. Chemobrain

Part 2: Methods and toxicity models in toxicology
7. "Predictive in silico toxicology." An update on modern approaches and a critical analysis of its strong and weak points
8. Analytical strategies to study the gut microbiome in toxicology
9. Behavioral endpoints in adult and developmental neurotoxicity: the case of organophosphate pesticides
10. Nuclear factor erythroid 2-related factor 2-mediated antioxidant response as an indicator of oxidative stress
11. The potential of complex in vitro models in pharmaceutical toxicology

Part 3: New insights in risk assessment
12. Health-based exposure limits and toxicology in pharmaceutical industry
13. The hormetic dose response: implications for risk assessment
14. Endocrine disruption and human health risk assessment in light of real-life risk simulation
15. Toxicity data as the basis for acute and short-term emergency exposure guidance
16. Renal mitochondria as sentinels for exposures to environmental toxicants and nephrotoxic drugs

Part 4: Clinical biomarkers updates
17. Updates on current biomarkers in toxicology
18. The role of extracellular matrix in allergic contact dermatitis pathogenesis
19. Review of current neurotoxicology issues
20. Modern aspects of immunotoxicology
21. Toxicology of neurodegenerative diseases
22. Toxicogenetics—Pharmacogenetics: genetic variability profiling for xenobiotic response heterogeneity
23. Current and emerging concepts of cardiotoxicity
24. Metabolomics: diagnostic and therapeutic applications in clinical medicine and pharmacology
25. Metabolomics methodology and workflow: challenges and future prospects
26. Telomere length: associations with nutrients and xenobiotics

Part 5: Epidemiology and public health toxicology issues
27. Dismissing the use of P-values and statistical significance testing in scientific research: new methodological perspectives in toxicology and risk assessment
28. Modern approaches for the assessment of human exposure to dietary mycotoxins
29. Tobacco toxicity and regulatory science
30. Dethroning the crown. From the kinetics and dynamics of COVID-19 diagnosis to the promising treatments
31. Toxicology issues related to COVID-19 outbreak
32. Risk assessment for heat stress during work and leisure

Part 6: Pharmaceuticals and nutraceuticals toxicology updates
33. Polyphenols: the hallmark of endothelial dysfunction combatants
34. Effect of diet, pharmaceuticals, and environmental toxicants on gut microbiota imbalance and increased intestinal membrane permeability
35. Hydrogen sulfide: a shifting paradigm
36. Redox biomarkers in toxicology and nutrition: the social link
37. Safety profile of plants and phytoconstituents used in traditional medicine worldwide

Part 7: Toxicology of biomaterials and nanomaterials
38. Epigenetic mechanisms in nanomaterial toxicity
39. Predictive nanotoxicology: from nanotoxicity to nanosafety of select and commonly used nanomaterials
40. The toxicological effects of titanium dioxide nanoparticles on marine microalgae
41. Aquatic nanotoxicology: reference species and omics technologies

Part 8: Special topics in toxicology
42. Toxicity of arsenicals in diseases: friend or foe?
43. Toxicity of psychedelic drugs
44. Immunotoxicity of pesticides: current knowledge and perspectives
45. Glyphosate-based herbicides: evidence of immune-endocrine alteration
46. Ciguatera toxins: toxicity and food safety
47. Cannabinoids and psychosis: current challenges of mechanistic toxicology
48. Electronic cigarettes as a harm reduction concept for public health


No. of pages:
© Academic Press 2021
1st August 2021
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editor

Aristidis Tsatsakis

Aristidis Tsatsakis is Director of the Department of Toxicology and Forensic Sciences of the Medical School at the University of Crete and the University Hospital of Heraklion. He has more than 1000 publications, including 700 in ISI journals and is extensively cited. He was EUROTOX President (2014–16) and still an Emeritus Professor for the Federal Institute of Hygiene and Toxicology in Moscow. He is Doctor Honoris Causa of the Mendeleev Moscow University, the Far East Federal University (FEFU), Vladivostok, and the Carol Davila in Bucharest. He is a Foreign Member of the National Academy of Sciences of Russia (FMRAS) and a Fellow of the Academy of Toxicological Sciences (FATS, United States). He is the creator, founder, and chief scientific officer of ToxPlus SA. He developed numerous biomarkers of exposure and of effects for the pesticide and chemical toxicology field, uncovering the mechanistic understanding of the mode of actions, adverse outcome pathways, and clinical affects. He is currently the Editor of Food Chemical Toxicology, Editor-in-Chief of Toxicology Reports, Guest Editor of four special issues in Toxicology Letters, Toxicology and Food and Chemical Toxicology journals, Guest Editor of the RIFM-Food and Chemical Toxicology issue, Associate Editor, and member of the Editorial Boards in several other ISI indexed journals. He has also been recognized as Highly Cited Researcher 2020 in the field of Pharmacology–Toxicology (Publons).

Affiliations and Expertise

Director, Department of Toxicology and Forensic Sciences, Medical School, University of Crete, University Hospital of Heraklion, Crete, Greece

Ratings and Reviews