Toxicological Evaluation of Electronic Nicotine Delivery Products

Toxicological Evaluation of Electronic Nicotine Delivery Products　(ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them.　This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.

• Delivers a comprehensive overview of current state of science
• Offers an integrated analysis of e-cigarettes and heated tobacco products
• Provides guidance for methodologies

Toxicologists (academia, regulatory authorities and industry); Public health professionals (academia, government)

1. Tobacco Harm Reduction
2. Electronic nicotine delivery devices (ENDS)
3. The scientific basis for the assessment of ENDS
4. Quantification of HPHC in ENDS aerosols
5. Aerosol physics and dynamics
6. Advanced analytical chemistry methods to characterize ENDS aerosols
7. Other species of toxicological concern
8. Impact of ENDS on indoor air quality
9. A systems-based approach to toxicity testing
10. Translational aspects of toxicity testing
11. Dosimetry and human-relevant exposure
12. Aerosol generation, exposure, and collection
13. Toxicological assessment in vitro
14. Toxicological assessment in vivo
15. Assessment of in vivo models of disease
16. Flavors and their toxicological assessment
17. A clinical strategy for ENDS testing
18. The disease risk reduction potential of ENDS
19. Residual risk associated to nicotine
20. Conclusion