Toxicogenomics-Based Cellular Models

List of Contributors

Section 1: Introduction to Toxicogenomics-Based Cellular Models

Chapter 1.1. Introduction to Toxicogenomics-Based Cellular Models

1.1.1 The demands for alternatives to current animal test models for chemical safety

1.1.2 The toxicogenomics approach

1.1.3 Upgrading cellular models

1.1.4 Regulatory aspects

1.1.5 This book

References

Section 2: Genotoxicity and Carcinogenesis

Chapter 2.1. Application of In Vivo Genomics to the Prediction of Chemical-Induced (hepato)Carcinogenesis

2.1.1 Introduction

2.1.2 Toxicogenomics-based prediction of hepatocarcinogenic hazard

2.1.3 Conclusion and future perspective

References

Chapter 2.2. Unraveling the DNA Damage Response Signaling Network Through RNA Interference Screening

2.2.1 The DNA-damage-induced signaling response

2.2.2 DNA-damage-induced cellular responses

2.2.3 DNA damage in the context of cancer formation and treatment

2.2.4 RNAi screens to study the DDR signaling network

References

Section 3: Immunotoxicity

Chapter 3.1. Immunotoxicity Testing: Implementation of Mechanistic Understanding, Key Pathways of Toxicological Concern, and Components of These Pathways

3.1.1 Introduction

3.1.2 Animal-free assays to detect immunotoxicological endpoints

3.1.3 Toxicogenomics approaches to predicting chemical safety

3.1.4 Gaps and hurdles on the way to risk assessment and human safety

3.1.5 An applied systems toxicology approach to predicting chemical safety

References

Chapter 3.2. Chemical Sensitization

3.2.1 Introduction

3.2.2 Three-dimensional human skin equivalent as a tool for safety testing purposes

3.2.3 Skin sensitization in keratinocytes

3.2.4 Toxicogenomic analysis of cutaneous responses

3.2.5 Alternatives for animal testing of chemi