Toxicogenomics-Based Cellular Models

1st Edition

Alternatives to Animal Testing for Safety Assessment

Editors: Jos Kleinjans
Hardcover ISBN: 9780123978622
eBook ISBN: 9780123978714
Imprint: Academic Press
Published Date: 29th January 2014
Page Count: 362
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Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores ‘omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing.

Key Features

  • Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity
  • Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays
  • Includes an overview of current testing methods and risk assessment frameworks
  • Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward


Scientists, academics and students within the fields of toxicology and molecular biology, as well as regulatory authorities involved in chemical safety

Table of Contents

List of Contributors

Section 1: Introduction to Toxicogenomics-Based Cellular Models

Chapter 1.1. Introduction to Toxicogenomics-Based Cellular Models

1.1.1 The demands for alternatives to current animal test models for chemical safety

1.1.2 The toxicogenomics approach

1.1.3 Upgrading cellular models

1.1.4 Regulatory aspects

1.1.5 This book


Section 2: Genotoxicity and Carcinogenesis

Chapter 2.1. Application of In Vivo Genomics to the Prediction of Chemical-Induced (hepato)Carcinogenesis

2.1.1 Introduction

2.1.2 Toxicogenomics-based prediction of hepatocarcinogenic hazard

2.1.3 Conclusion and future perspective


Chapter 2.2. Unraveling the DNA Damage Response Signaling Network Through RNA Interference Screening

2.2.1 The DNA-damage-induced signaling response

2.2.2 DNA-damage-induced cellular responses

2.2.3 DNA damage in the context of cancer formation and treatment

2.2.4 RNAi screens to study the DDR signaling network


Section 3: Immunotoxicity

Chapter 3.1. Immunotoxicity Testing: Implementation of Mechanistic Understanding, Key Pathways of Toxicological Concern, and Components of These Pathways

3.1.1 Introduction

3.1.2 Animal-free assays to detect immunotoxicological endpoints

3.1.3 Toxicogenomics approaches to predicting chemical safety

3.1.4 Gaps and hurdles on the way to risk assessment and human safety

3.1.5 An applied systems toxicology approach to predicting chemical safety


Chapter 3.2. Chemical Sensitization

3.2.1 Introduction

3.2.2 Three-dimensional human skin equivalent as a tool for safety testing purposes

3.2.3 Skin sensitization in keratinocytes

3.2.4 Toxicogenomic analysis of cutaneous responses

3.2.5 Alternatives for animal testing of chemi


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© Academic Press 2014
Academic Press
eBook ISBN:
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About the Editor

Jos Kleinjans

Affiliations and Expertise

Professor and Chair, Department of Toxicogenomics, Maastricht University, the Netherlands


"Researchers in genetics, toxicology, and other medical and public health specialties describe the current progress in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, and reproductive toxicity, all important endpoint of toxicity, the evaluation of which now costs large numbers of animal lives.", April 2014