
Toxicoepigenetics
Core Principles and Applications
Resources
Description
Key Features
- Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology
- Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds
- Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications
Readership
Researchers, academics, and advanced students and in toxicology and related fields. Investigators, risk assessors and regulators in academia, industry and government.
Table of Contents
Prelude
Introduction to the Role of the Epigenome in Health and Disease
Section 1
1. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation
2. The Role of Histone Methylation and Methyltransferases in Gene Regulation
3. Linking Chromatin Accessibility with Exposure Effects and Susceptibility
4. Implications for Chromatin Biology in Toxicology
Section 2
5. The Role of DNA Methylation in Gene Regulation
6. Implications of DNA Methylation in Toxicology
7. DNA Methylation as a Biomarker in Environmental Epidemiology
8. DNA Hydroxymethylation: Implications for Toxicology and Epigenetic Epidemiology
Section 3
9. The Role of Non-Coding RNAs in Gene Regulation
10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure
Section 4
11. Germline and Trans-generational Impacts of Toxicant Exposures
12. Novel Bioinformatics Methods for Toxicoepigenetics
13. Incorporating Epigenetics into Risk Assessment Frameworks
Section 5
14. Chromatin Immunoprecipitation: General Protocol and Considerations for Analysis
15. Methods for Analysis of DNA Methylation
16. Methods for Analyzing miRNA Expression
Product details
- No. of pages: 428
- Language: English
- Copyright: © Academic Press 2018
- Published: November 2, 2018
- Imprint: Academic Press
- eBook ISBN: 9780128124345
- Paperback ISBN: 9780128124338