Toxicoepigenetics

Toxicoepigenetics

Core Principles and Applications

1st Edition - November 2, 2018

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  • Editors: Shaun Mccullough, Dana Dolinoy
  • eBook ISBN: 9780128124345
  • Paperback ISBN: 9780128124338

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Description

Toxicoepigenetics: Core Principles and Applications examines the core aspects of epigenetics, including chromatin biology, DNA methylation, and non-coding RNA, as well as fundamental techniques and considerations for studying each of these mechanisms of epigenetic regulation. Although its integration into the field of toxicology is in its infancy, epigenetics have taken center stage in the study of diseases such as cancer, diabetes, and neurodegeneration. Increasing the presence of epigenetics in toxicological research allows for a more in-depth understanding of important aspects of toxicology such as the role of the environment and lifestyle influencing the individual susceptibility to these effects and the trans-generational transmission of these health effects and susceptibilities. Methods chapters are included to help improve efficacy and efficiency of protocols in both the laboratory and the classroom. Toxicoepigenetics: Core Principles and Applications is an essential book for researchers and academics using epigenetics in toxicology research and study.

Key Features

  • Introduces the fundamental principles and practices for understanding the role of the epigenome in toxicology
  • Presents the foundation of epigenetics for toxicologists with a broad range of backgrounds
  • Discusses the incorporation of epigenetics and epigenomics into current toxicological studies and interpretation of epigenetic data in toxicological applications

Readership

Researchers, academics, and advanced students and in toxicology and related fields. Investigators, risk assessors and regulators in academia, industry and government.

Table of Contents

  • Prelude

    Introduction to the Role of the Epigenome in Health and Disease

    Section 1

    1. The Role of Histone Acetylation and Acetyltransferases in Gene Regulation

    2. The Role of Histone Methylation and Methyltransferases in Gene Regulation

    3. Linking Chromatin Accessibility with Exposure Effects and Susceptibility

    4. Implications for Chromatin Biology in Toxicology

    Section 2

    5. The Role of DNA Methylation in Gene Regulation

    6. Implications of DNA Methylation in Toxicology

    7. DNA Methylation as a Biomarker in Environmental Epidemiology

    8. DNA Hydroxymethylation: Implications for Toxicology and Epigenetic Epidemiology

    Section 3

    9. The Role of Non-Coding RNAs in Gene Regulation

    10. miRNAs and lncRNAs as Biomarkers of Toxicant Exposure

    Section 4

    11. Germline and Trans-generational Impacts of Toxicant Exposures

    12. Novel Bioinformatics Methods for Toxicoepigenetics

    13. Incorporating Epigenetics into Risk Assessment Frameworks

    Section 5

    14. Chromatin Immunoprecipitation: General Protocol and Considerations for Analysis

    15. Methods for Analysis of DNA Methylation

    16. Methods for Analyzing miRNA Expression

Product details

  • No. of pages: 428
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: November 2, 2018
  • Imprint: Academic Press
  • eBook ISBN: 9780128124345
  • Paperback ISBN: 9780128124338

About the Editors

Shaun Mccullough

Dr. McCullough’s lab focuses around the role of the epigenome as both a molecular mechanism mediating the effects of toxic exposures and as a biomarker for predicting susceptible populations and identifying factors that can be used to mitigate adverse exposure outcomes. The lab employs a translational research approach to toxicology that uses both advanced in vitro primary cell models and in vivo clinical controlled human exposure studies. Dr. McCullough completed his postdoctoral training at the US EPA where he identified novel pathways of single and multi-toxicant mediated stress, for which he received the Molecular and Systems Biology Specialty Section Postdoctoral Fellow Award, the US EPA Superior Achievement Award, and the Gabriel L. Plaa Education Award. Dr. McCullough’s research is focused on investigating the role of the epigenome as a mediator of inter-individual variability in toxicant-induced health effects and susceptibility using in vitro and human exposure models. Dr. McCullough is the Chairman of the US EPA’s National Health and Environmental Effects Research Laboratory Epigenetics Workgroup, a founding member of the University of North Carolina’s Program in Chromatin and Epigenetics, and is on the Board of Directors for the American Society for Cellular and Computational Toxicology.

Affiliations and Expertise

Principal Investigator - National Health and Environmental Effects Research Laboratory, Clinical Research Branch, United States Environmental Protection Agency, Chapel Hill, NC, USA

Dana Dolinoy

Dr. Dolinoy is Associate Professor of Environmental Health Sciences at the University of Michigan School of Public Health (UM SPH) and leads the Environmental Epigenetics and Nutrition Laboratory at UM SPH, which investigates how nutritional and environmental factors interact with epigenetic gene regulation to shape health and disease. Dr. Dolinoy holds a BA in environmental sciences and policy and Spanish from Duke University, an MSc in environmental sciences and engineering from the Harvard School of Public Health, and a PhD in Genetics and Genomics and Integrated Toxicology from Duke University. She serves on the Editorial Board for the Journal of Nutritional Biochemistry as well as Epigenetics, Environmental and Molecular Mutagenesis, and Toxicological Sciences, and is an active member of the Society of Toxicology (SOT), the Environmental Mutagen and Genomics Society (EMGS), and the American Society for Nutrition (ASN), and will serve as Chair of the 2015 Gordon Research Conference (GRC) in Molecular & Cellular Mechanisms of Toxicity. In 2011, Dr. Dolinoy received the Norman Kretchmer Memorial Award from ASN and the Classic Paper of the Year Award from Environmental Health Perspectives for Dolinoy et al. "Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome." In 2012, she was the recipient of the Association of Schools of Public Health (ASPH)/Pfizer Research Award for the article, "An Expression Microarray Approach for the Identification of Metastable Epialleles in the Mouse Genome." This work was cited as a model approach that may allow for directly assessing the role of early nutritional and environmental exposures in human adult disease. Dr. Dolinoy is an Associate Editor on the upcoming second edition of Elsevier’s MRW Comprehensive Toxicology.

Affiliations and Expertise

NSF International Chair of Environmental Health Sciences, Professor of Environmental Health Sciences & Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA

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