Total Body PET Imaging, An Issue of PET Clinics

1st Edition, Volume 16-1 - November 19, 2020
Editors: Ramsey Badawi, Joel S. Karp, Lorenzo Nardo, Austin Pantel
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 6 1 4 6 - 8
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 6 1 4 7 - 5

This issue of PET Clinics focuses on Total Body PET Imaging, and is edited by Drs. Lorenzo Nardo, Ramsey Badawi, Joel S. Karp and Austin Pantel. Articles will include: UC Davis… Read more

Total Body PET Imaging, An Issue of PET Clinics

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This issue of PET Clinics focuses on Total Body PET Imaging, and is edited by Drs. Lorenzo Nardo, Ramsey Badawi, Joel S. Karp and Austin Pantel. Articles will include: UC Davis update on the uEXPLORER; Zhongshan update on the uEXPLORER; UPenn update on the PennPET Explorer; Total body imaging instrumentation design considerations; 3D/4D reconstruction and quantitative total body imaging; Analysis of 4D data for total body imaging; Total body imaging and cancer; Total body imaging and metabolic disease; Total body imaging and infection; Total body imaging and musculoskeletal disease; Total body imaging and cardiovascular disease; Total body imaging and cardiac applications; Total body imaging and neuroimaging; and more!

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
CME Accreditation Page
Errata
Preface
Clinical Implementation of Total-Body PET/CT at University of California, Davis
Key points
Introduction
18F-FDG: studies in healthy subjects
Interactions with oncologists
18F-FDG: protocol selection
Initial experience with 18F-Fluciclovine and 68Ga-DOTATATE
Present and future challenges
Summary/future directions
Total-Body PET/Computed Tomography Highlights in Clinical Practice: Experiences from Zhongshan Hospital, Fudan University
Key points
Introduction
Total-body PET/computed tomography imaging
High-quality PET imaging
Lower dose injection or shorter acquisition time
Extended uptake time imaging
Total-body dynamic study
Disclosures
Update on the PennPET Explorer: A Whole-body Imager with Scalable Axial Field-of-View
Key points
Introduction
Design considerations
Performance characterization of PennPET Explorer prototype
Choice of axial field of view
Human studies on the prototype PennPET Explorer
Recent progress: expansion of the PennPET Explorer from the prototype configuration
Future studies on the PennPET Explorer
Summary
Scanner Design Considerations for Long Axial Field-of-View PET Systems
Key points
Introduction
History of long axial field-of-view scanners
Detector technology considerations for long axial field-of-view scanners
General scanner design considerations
Design specifics of long axial field-of-view scanners
Measurement of performance of long axial field-of-view systems
Data and computational challenges with long axial field-of-view systems
Further improvements in PET systems with a focus on long axial field-of-view designs
Summary
3D/4D Reconstruction and Quantitative Total Body Imaging
Key points
Introduction
List-mode three-dimensional image reconstruction
Efficient reconstruction using direct image reconstruction for time-of-flight data framework
Four-dimensional reconstruction for total-body dynamic PET
Summary and future prospects
Analysis of Four-Dimensional Data for Total Body PET Imaging
Key points
Introduction
Blood sampling from multiple locations
Measuring kinetics over a prolonged time period after injection
Low-dose dynamic imaging
Parametric image reconstruction
Four-dimensional lesion heterogeneity
Dual tracer imaging
Summary
Oncologic Applications of Long Axial Field-of-View PET/Computed Tomography
Key points
Introduction
Shorter scan time
Low dose
Delayed imaging
Total body imaging
Increased detection challenges
Future directions
Summary
Total-body PET Imaging: A New Frontier for the Assessment of Metabolic Disease and Obesity
Key points
Introduction
Understanding obesity and its related metabolic abnormalities
Approaches for the assessment of metabolic function in clinical practice and research
Standard PET versus total-body PET for the assessment of metabolic health
Obesity and metabolism research areas that could benefit from total-body PET
Limitations and future research opportunities
Clinics care points
Total-Body PET Imaging in Infectious Diseases
Key points
Role of PET imaging in infectious diseases clinical care and pathogenesis research
Advantages of total-body PET imaging
Potential for total-body PET imaging in infectious diseases
Example of molecular imaging of immune responses to infectious diseases highlighting the need for total-body PET imaging
Summary and future development
Total-Body PET Imaging of Musculoskeletal Disorders
Key points
Introduction
Rheumatoid and psoriatic arthritis
Osteoarthritis and degenerative conditions
Fever of unknown origin
Osteopenia and osteoporosis
Skeletal muscle
Neoplastic musculoskeletal diseases
Discussion
Assessment of Total-Body Atherosclerosis by PET/Computed Tomography
Key points
Introduction
Atherosclerotic disease burden or vulnerable plaque
PET tracers for atherosclerosis imaging
18F-fluorodeoxyglucose and 18F-sodium fluoride PET imaging in atherosclerosis
PET equipment for partial-body or total-body assessment
Artificial intelligence–based interpretation
Cost-effectiveness
Summary
Potential Cardiovascular Applications of Total-body PET Imaging
Key points
Introduction/history/definitions/background
Potential cardiovascular applications
Summary
Disclosure
Frontiers in Neuroscience Imaging: Whole-Body PET
Key points
Introduction
Human nervous system overview
Whole-body measurement of neurotransmission and physiology
Whole-body PET imaging of neurodegenerative disease
Evaluation of pharmacotherapies: pharmacokinetics and pharmacodynamics
Summary