Tissue Engineering

Tissue Engineering

1st Edition - March 25, 2008

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  • Authors: Clemens Van Blitterswijk, Jan De Boer, Peter Thomsen, Jeffrey Hubbell, Ranieri Cancedda, J.D. de Bruijn, Anders Lindahl, Jerome Sohier, David Williams
  • eBook ISBN: 9780080559193
  • Hardcover ISBN: 9780123708694

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Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students and professionals who are developing their knowledge of this important topic. Key topics covered include stem cells; morphogenesis and cellular signaling; the extracellular matrix; biocompatibility; scaffold design and fabrication; controlled release strategies; bioreactors; tissue engineering of skin, cartilage, bone and organ systems; and ethical issues.

Key Features

  • Covers all the essentials from tissue homeostasis and biocompatibility to cardiovascular engineering and regulations
  • 22 chapters from internationally recognized authors, provide a comprehensive introduction for engineers and life scientists, including biomedical engineers, chemical and process engineers, materials scientists, biologists and medical students
  • Full colour throughout, with clear development of understanding through frequent examples, experimental approaches and the latest research and developments


students studying biomedical and tissue engineering; researchers; scientists

Table of Contents

  • 1. Stem cells
    2. Morphogenesis, generation of tissue in the embryo
    3. Tissue homeostasis
    4. Cellular signaling
    5. The extracellular matrix as a biologic scaffold for tissue engineering
    6. Natural polymers in tissue engineering applications
    7. Degradable polymers for tissue engineering
    8. Degradation of bioceramics
    9. Biocompatibility
    10. Cell source
    11. Cell culture: harvesting, selection, expansion, and differentiation
    12. Cell nutrition
    13. Cryobiology
    14. Scaffold design and fabrication
    15. Controlled release strategies in tissue engineering
    16. Bioreactors for tissue engineering
    17. Tissue engineering for skin transplantation
    18. Tissue engineering of cartilage
    19. Tissue engineering of bone
    20. Tissue engineering of the nervous system
    21. Tissue engineering of organ systems
    22. Ethical issues in tissue engineering

Product details

  • No. of pages: 776
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: March 25, 2008
  • Imprint: Academic Press
  • eBook ISBN: 9780080559193
  • Hardcover ISBN: 9780123708694

About the Authors

Clemens Van Blitterswijk

Clemens Van Blitterswijk
Clemens van Blitterswijk graduated as cell biologist from Leiden University in 1982, defending his PhD thesis in 1985 at the same university. Today his research focuses on tissue engineering and regenerative medicine, forming a unique basis of multidisciplinary research between materials and life sciences. Van Blitterswijk has authored and co-authored more than 380 peer reviewed papers (H index 90, Scopus); is one of the most frequently cited Dutch scientists in TE; the applicant and co-applicant of over 100 patents; has guided 50 PhD candidates through their thesis as supervisor or co-supervisor and currently has 30 PhD candidates under his supervision. Dr. van Blitterswijk received a number of prestigious international awards including the George Winter award of the European society for Biomaterials, the Career Achievement Award of the Tissue Engineering and Regenerative Medicine International Society and is a member of the KNAW (The Royal Netherlands Academy of Arts and Sciences).

Affiliations and Expertise

KNAW (The Royal Netherlands Academy of Arts and Sciences), The Netherlands

Jan De Boer

Jan De Boer
Jan de Boer is an experienced University Professor and Chief Scientific Officer with a demonstrated history of working in academia and biotech. As a research professional he is skilled in Stem Cells, Biomaterial Engineering and Regenerative Medicine.  Jan is interested in the molecular complexity of cells and how molecular circuits are involved in cell and tissue function. With a background in mouse and Drosophila genetics, he entered the field of biomedical engineering in 2002 and has since focused on understanding and implementing molecular biology in the field of tissue engineering and regenerative medicine. His research is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology, to streamline the wealth of biological knowledge to real clinical applications.

Affiliations and Expertise

Professor, Department of Biomedical Engineering, The Netherlands

Peter Thomsen

Affiliations and Expertise

Goteborg University, Institute of Anatomy and Cell Biology, Sweden

Jeffrey Hubbell

Affiliations and Expertise

ETH in Lausanne, Institute for Biomaterials Engineering Laboratory of Regenerative Medicine and Pharmacology, Switzerland

Ranieri Cancedda

Affiliations and Expertise

Laboratoriodi di Medicina Rigenerativa, CBA, Genoa, Italy

J.D. de Bruijn

Affiliations and Expertise

Queen Mary University of London

Anders Lindahl

Affiliations and Expertise

Sahlgrenska University Hospital, Sweden

Jerome Sohier

Affiliations and Expertise

Université de Nantes, France

David Williams

Professor Williams has had 48 years experience in biomaterials, medical device and tissue engineering, working mostly at the University of Liverpool, UK where he was ultimately Professor of Biomaterials and Biomedical Engineering, Director of the UK Centre for Tissue Engineering and Senior Pro-Vice Chancellor of the University. During his career he has published over 30 books and 400 papers: his latest book, Essential Biomaterials Science, was published by Cambridge University Press in June 2014. He was Editor-in-Chief of Biomaterials, the world’s leading journal in this field between 2000 and 2014. He has received the major awards from the US, European and Indian societies of biomaterials including the Founders Award of the US Society for Biomaterials in 2007, and received the prestigious Acta Biomaterialia Gold Medal in 2012. In 1999 he was elected as a Fellow of the Royal Academy of Engineering and is a Foreign Fellow of the Indian National Academy of Engineering and a Fellow of the American Institute of Medical and Biological Engineering, all in recognition of his contributions to engineering in medicine. He was global President of the Tissue Engineering & Regenerative Medicine International Society from 2013-2015. He was a scientific advisor to several divisions of the European Commission during the 1990s and wrote several opinions on which European actions were taken. He has, over the last 20 years, given evidence in several major product liability and patent legal cases in the USA, Europe and Australia.

Professor Williams left the University of Liverpool in 2007. While retaining the title of Emeritus Professor at Liverpool, he is currently Professor and Director of International Affairs, Wake Forest Institute of Regenerative Medicine, North Carolina, USA. In addition, he is a Visiting Professor in the Christiaan Barnard Department of Cardiothoracic Surgery, Cape Town, South Africa, a Adjunct Professor at the University of Technology, Sydney, Australia, and a Guest Professor, at Tsinghua University, Beijing, and Advisory Professor at Shanghai Jiao Tong University, China. He is Visiting Chair Professor of Biomedical Materials, Taipei Medical University, Taiwan. In Cape Town, along with Professor Peter Zilla, the current Chris Barnard Professor of Surgery, he has formed a company that will produce low cost but high technology medical devices that can be used with minimally invasive procedures to treat young adults in sub-Sarah Africa, who are suffering from rheumatic heart disease but currently have no therapies available to them.

Affiliations and Expertise

Professor of Biomaterials and Biomedical Engineering, Department of Clinical Engineering, University of Liverpool, UK

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