Times, Cells, and Aging

Times, Cells, and Aging

2nd Edition - January 28, 1977

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  • Author: Bernard Strihler
  • eBook ISBN: 9780323161695

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Description

Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism’s deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Table of Contents


  • Preface

    Preface to the First Edition

    I Introduction

    Text

    II Definitions, Criteria, Categories, and Origins of Age Changes

    A. Definitions

    B. Criteria of Age Changes

    C. Categories of Age Changes

    D. Origins of Age Changes

    E. Kinetic Distinctions between Genetic and Stochastic Processes

    III The Distribution of Cellular Aging

    A. Nonaging Systems

    B. On Species Which May Not Age

    C. Mortal and Immortal Clones

    IV Aging Biosystems: Invertebrates

    A. General Considerations

    B. Protozoa

    C. Metazoa

    D. Summary

    V Ultimate Effects of Cellular Aging—Mortality—Review of Theories of Mortality

    A. Mortality Rate

    B. Statement and Critique of Theories

    VI Proximate Effects of Cellular Aging

    A. Physiological Decline

    B. Diffuse Changes Affecting the Function of a Variety of Organ Systems

    C. Functional Changes in Specific Organ Systems during the Aging Process

    VII Aging of Cell Aggregates and Tissues

    A. General Considerations

    B. The Loci of Tissue Changes

    C. Tissue Disorganization and Change

    D. Cell Death and Changes in Cell Number

    VIII Aging of Subcellular Components

    A. Cell Turnover

    B. Metabolic Turnover

    C. Changes in Subcellular Organelles and Constituents

    IX Theories on the Mechanisms of Aging

    Part I. Theories and Evidence on the Sources of Structural Instability

    A. Thermal and Chemical Instabilities of Functional Units

    B. The Somatic Mutation Theory of Aging

    C. Disruption of Intercellular Relationships and Dependencies

    Part II. Theories and Evidence on Inadequacies in Informational Processing: Timing, Codes, and Aging

    A. The Error Theory of Aging

    B. Developmental Program and Aging Theories: Time, Gene Expression, and Aging

    C. Timing, Neuronal Codes, and Aging

    Part III. An Integrated Theory of Aging

    Summary

    X The Evolution of Cellular Aging and Longevity

    A. The Evolution of Senescence

    B. The Evolution of Longevity

    XI Some Unexplored Avenues of Cellular Aging—Current and Future Research

    Implementation of an Effective Aging Research Effort

    Bibliography

    Appendix A

    Appendix B

    Appendix C

    Author Index

    Subject Index


Product details

  • No. of pages: 470
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 28, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323161695

About the Author

Bernard Strihler

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