Tietz Textbook of Clinical Chemistry and Molecular Diagnostics - 5th Edition

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

5th Edition

Authors: Carl Burtis Edward Ashwood David Bruns
Imprint: Saunders


As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics.

Key Features

  • Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson.
  • Highly-respected author team includes three editors who are well known in the clinical chemistry world.
  • Reference values in the appendix give you one location for comparing and evaluating test results.

Table of Contents

Section I: Principles of Laboratory Medicine

  1. Introduction to Laboratory Medicine
  2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
  3. Clinical Evaluation of Methods
  4. Evidence Based Laboratory Medicine
  5. Establishment and Use of Reference Values
  6. Preanalytical Variables and Biological Variation
  7. Specimen Collection and Processing
  8. Quality Management
  9. Section II: Analytical Techniques and Instrumentation

  10. Principles of Basic Techniques and Laboratory Safety
  11. Optical Techniques
  12. Electrochemistry and Chemical Sensors
  13. Electrophoresis
  14. Chromatography and Extraction
  15. Mass Spectrometry
  16. Enzyme and Rate Analyses
  17. Principles of Immunochemical Techniques
  18. Nucleic Acid Techniques
  19. Microfabrication and Microfluidics and Their Application to Clinical Diagnostics
  20. Automation in the Clinical Laboratory
  21. Point-of-Care Testing
  22. Section III: Analytes

  23. Amino Acids, Peptides, and Proteins
  24. Serum Enzymes
  25. Enzymes of the Red Blood Cell
  26. Tumor Markers
  27. Kidney Function Tests
  28. Carbohydrates
  29. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
  30. Electrolytes and Blood Gases
  31. Hormones
  32. Catecholamines and Serotonin
  33. Vitamins and Trace Elements
  34. Hemoglobin, Iron, and Bilirubin
  35. The


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About the Author

Carl Burtis

Affiliations and Expertise

Health Services Division, Oak Ridge National Laboratory, Oak Ridge, TN, and Clinical Professor of Pathology, University of Utah School of Medicine, Salt Lake City, UT

Edward Ashwood

Affiliations and Expertise

Professor of Pathology, University of Utah School of Medicine, and President and CEO, ARUP Laboratories, Salt Lake City, UT

David Bruns

Affiliations and Expertise

Professor of Pathology, University of Virginia School of Medicine, Director of Clinical Chemistry and Associate Director of Molecular Diagnostics, University of Virginia Health System, Charlottesville, VA, and Former Editor, Clinical Chemistry, Washington, DC