Tietz Fundamentals of Clinical Chemistry - 6th Edition - ISBN: 9780721638652, 9781437719406

Tietz Fundamentals of Clinical Chemistry

6th Edition

Authors: Carl Burtis David Bruns
eBook ISBN: 9781437719406
Imprint: Saunders
Published Date: 6th November 2007
Page Count: 976

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A condensed, student-friendly version of Tietz Textbook of Clinical Chemistry, this text uses a laboratory perspective to provide you with the chemistry fundamentals you need to work in a real-world, clinical lab. Accurate chemical structures are included to explain the key chemical features of relevant molecules. Offering complete, accurate coverage of key topics in the field, it's everything that you expect from the Tietz name!

Key Features

  • More than 500 illustrations and easy-to-read tables help you understand and remember key concepts.
  • Key words, learning objectives, and other student-friendly features reinforce important material.
  • Chapter review questions are included in an appendix to test your knowledge.
  • A two-color design makes it easier to read and easy to find important topics.
  • In-depth, reader-friendly content is appropriate for MT/CLS and MLT/CLT students and may also be used by laboratory practitioners, pathology residents, and others.

Table of Contents


1. Introduction to Clinical Chemistry and Evidence-Based Laboratory Medicine

2. Introduction to Principles of Laboratory Analyses and Safety

3. Specimen Collection and Other Pre-Analytical Variables


4. Optical Techniques

5. Electrochemistry and Chemical Sensors

6. Electrophoresis

7. Chromatography

8. Mass Spectrometry

9. Principles of Clinical Enzymology

10. Principles of Immunochemical Techniques

11. Automation in the Clinical Laboratory

12. Point-of-Care Testing


13. Selection and Analytical Evaluation of Methods — With Statistical Techniques

14. Establishment and Use of Reference Values

15. Clinical Laboratory Informatics

16. Quality Management


17. Nucleic Acids

18. Amino Acids and Proteins

19. Enzymes

20. Tumor Markers

21. Creatinine, Uric acid, and Urea

22. Carbohydrates

23. Lipids, Lipoproteins, and Cardiac Risk Factors

24. Electrolytes and Blood Gases

25. Hormones

26. Catecholamines and Serotonin

27. Vitamins and Trace Elements

28. Hemoglobin, Iron, and Bilirubin
29. Porphyrins and Disorders of Porphyrin Metabolism

30. Therapeutic Drugs

31. Clinical Toxicology

32. Toxic Metals


33. Cardiovascular Disease

34. Renal Disease

35. Disorders of Water, Electrolyte, and Acid-Base Metabolism

36. Liver Disease

37. Gastric, Pancreatic, and Intestinal Diseases

38. Disorders of Bone

39. Pituitary Disorders

40. Adrenal Cortical Disorders

41. Thyroid Disorders

42. Reproductive Disorders

43. Disorders of Pregnancy

44. Newborn Screening


45. Reference Information for the Clinical Laboratory

Appendix: Review Questions



No. of pages:
© Saunders 2008
eBook ISBN:

About the Author

Carl Burtis

Affiliations and Expertise

Health Services Division, Oak Ridge National Laboratory, Oak Ridge, TN, and Clinical Professor of Pathology, University of Utah School of Medicine, Salt Lake City, UT

David Bruns

Affiliations and Expertise

Professor of Pathology, University of Virginia School of Medicine, Director of Clinical Chemistry and Associate Director of Molecular Diagnostics, University of Virginia Health System, Charlottesville, VA, and Former Editor, Clinical Chemistry, Washington, DC


NEW REVIEW -- BURTIS / Tietz Fundamentals of Clinical Chemistry, 6th Edition.
Elsevier, 2008, $96.95. Imprint: Saunders.

Burtis, Carl A., PhD; Ashwood, Edward R., MD; Bruns, David E., MD

ISBN: 978-0-7216-3865-2, NLM: QY 90, LC: RB40, 952 pages, hard cover.


Valerie L. Ng, PhD, MD(Alameda County Medical Center/Highland Hospital)

This is the sixth edition of what is appropriately recognized as one of the cornerstone reference books for clinical chemistry. The fifth edition was published 2001.

This is as a comprehensive clinical chemistry book.

Intended for anyone interested in clinical chemistry, the book would be of obvious use to clinical laboratory scientists (practicing or in training) or clinical chemists (fellows or practicing). It would also be of interest to clinical pathologists (residents or practicing). Finally, it would be of interest to anyone who orders any of these tests and uses them to help in clinical care (i.e., MDs, medical students, residents, fellows, nurse practitioners, etc.) The editors and authors are well known and credible authorities.

Every time I turn around, there's a new Tietz clone. Specifically, all released within the past year or so and all edited by the same group, there is this sixth edition, there is the fourth edition of the Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Burtis et al. (Elsevier,
2006) (mammoth combo book), and there is the newly released Fundamentals of Molecular Diagnostics, Bruns et al (Elsevier, 2007). How do these three books interrelate? This sixth edition nicely carries on the tradition of excellence long associated with Tietz Fundamentals of Clinical Chemistry. Of note and unique to this book (compared to the two other Tietz variants) is a standardized chapter format beginning with key words and key concepts and ending with self-assessment questions. Additional material is available on the Evolve website for the more curious. But how come this 952-page book is only about one-third the size of the Tietz Textbook, even though it has only 11 fewer chapters? And why does it have 1,460 fewer pages than the Tietz Textbook, when the molecular diagnostics book has only 267 pages? So here's the difference: this book is focused primarily on the laboratory aspects of clinical chemistry.
While organ systems and clinical relevance of tests are discussed in this book, they are not discussed in the detail or depth as in the textbook. This book is nicely designed for the student with integrated educational tools. The textbook has much more detailed information but lacks integration with educational aids.
The molecular diagnostics book has more current information than the textbook.
Finally, in terms of weight, the molecular diagnostics book is lightweight, the fundamentals book is near the limit of my lifting capacity, and the textbook - you can injure yourself trying to heft it around if your upper body strength is limited like mine. If you want the best bang for your buck though, I'd recommend the textbook, but make sure you buff up at the gym before regular use.

This fundamentals book is a nice update to a well recognized authoritative text on clinical chemistry. I'd heartily recommend this for CLS students and clinical chemistry fellows. Meanwhile, I'd recommend the textbook for practicing pathologists/clinical chemists/pathology residents for the extra detail and depth needed for everyday practice.


Weighted Numerical Score: 94 - 4 Stars!