
Third Generation EGFR Inhibitors
Overcoming EGFR Resistance and Toxicity Problems
Description
Key Features
- Includes full synthetic schemes of all approved and in-trial third generation inhibitors
- Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds
- Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity
Readership
Medicinal chemists, Computational chemists, Organic chemists, Pharmacologists, Oncologists, Researchers in academia and industry
Table of Contents
1. Introduction
2. Approved and Clinical Trial Third Generation EGFR inhibitors
3. Current approaches in the development of Covalent Irreversible EGFR Inhibitors
4. Current approaches in the development of Covalent Reversible EGFR Inhibitors
5. Mechanism of Resistance to Third Generation Inhibitors
6. Discovery of Fourth Generation Allosteric C797S Inhibitors
7. Conclusion and Future Perspectives
Product details
- No. of pages: 208
- Language: English
- Copyright: © Elsevier 2018
- Published: November 27, 2018
- Imprint: Elsevier
- eBook ISBN: 9780081026625
- Paperback ISBN: 9780081026618
About the Authors
Harun Patel
Affiliations and Expertise
Rahul Pawara
Affiliations and Expertise
Sanjay Surana
Affiliations and Expertise
Ratings and Reviews
Latest reviews
(Total rating for all reviews)
Padvi K. Fri Dec 20 2019
Third Generation EGFR Inhibitors 1st Edition Overcoming EGFR Resistance and Toxicity Problems
Third Generation EGFR Inhibitors 1st Edition Overcoming EGFR Resistance and Toxicity Problems
Eknath K. Mon Dec 24 2018
Third Generation Anti-cancer ( EGFR Inhibitors)
This book gives idea about synthesis of third generation EGFR inhibitors and how to overcome from their problems... Lots of data available in this book