Thermoregulation Part II - 1st Edition - ISBN: 9780444640741

Thermoregulation Part II, Volume 157

1st Edition

From Basic Neuroscience to Clinical Neurology

Series Volume Editors: Andrej A. Romanovsky
Hardcover ISBN: 9780444640741
Imprint: Elsevier
Published Date: 1st September 2018
Page Count: 364
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Table of Contents


1. Body temperature and clinical thermometry

2. Brain temperature

3. Body temperature in surgery: effects on outcomes


4. Heat exhaustion

5. Heatstroke

6. Accidental hypothermia

7. Fever and hypothermia in systemic inflammation

8. Hyperthermia and hypothermia in stress

9. Thermoregulation and drugs of abuse

10. Thermoregulation in anesthesia

11. Malignant hyperthermia

12. Neuroleptic malignant syndrome and serotonin syndrome

13. Acral coldness


14. Thermoregulation in multiple sclerosis

15. Thermoregulation in Parkinson’s disease

16. Thermoregulation in Alzheimer’s disease

17. Thermoregulation in epilepsy

18. Energy metabolism and thermoregulation in amyotrophic lateral sclerosis

19. Thermoregulatory disorders in Huntington’s disease and their comparison with disorders in amyotrophic lateral sclerosis

20. Thermoregulation in neuropathies

21. Thermoregulation in brain injury and stroke

22. Thermoregulation after spinal cord injury


23. Therapeutic hypothermia

24. Selective brain hypothermia

25. Therapeutic hyperthermia

26. Antipyretic therapy: Clinical pharmacology


Thermoregulation, Part II: From Basic Neuroscience to Clinical Neurology, Volume 155, not only reviews how body temperature regulation changes in neurological diseases, but also how this aspect affects the course and outcomes of each disease. Other sections of the volume review three therapeutic approaches that are aimed at manipulating body temperature, including induced hypothermia, induced hyperthermia and antipyretic therapy. The book is comprised of nine sections across two volumes, five dealing with the basic aspects of body temperature regulation and four dealing with the clinical aspects. Basic sections cover the Thermoregulation system, Thermoreceptors, Thermoeffectors, Neural pathways, and Thermoregulation as a homeostatic function.

In addition, the book covers the physiology and neuroanatomy of the thermoregulation system and provides descriptions of how the regulation of body temperature intervenes with other physiological functions (such as sleep, osmoregulation, and immunity), stress, exercise and aging. Basic sections serve as an introduction to the four clinical sections: Body Temperature, Clinical Significance, Abnormal Body Temperature, Thermoregulation in Neurological Disease and Therapeutic Interventions.

Key Features

  • Presents a clear, logical pathway from the fundamental physiology of thermoregulation, through neurobiology, to clinical applications and disease
  • Enables researchers and clinicians to better understand the value of temperature measurement in disease and the use of temperature as a therapy
  • Integrates content from a broad field of research, including topics on the molecular physiology of temperature receptors, to the management of accidental hypothermia


Basic and clinical researchers in neuroscience; fellows, residents, and practicing clinicians in neurology as well as other clinicians whose clinical focus includes temperature control (internal medicine, endocrinology)


No. of pages:
© Elsevier 2018
Hardcover ISBN:

Ratings and Reviews

About the Series Volume Editors

Andrej A. Romanovsky Series Volume Editor

Andrej A. Romanovsky, MD, PhD, is an integrative physiologist and neuroscientist studying body temperature regulation. Originally from St. Petersburg, Russia, Dr. Romanovsky was granted his MD with Distinction by the Ivan Pavlov Medical University (St. Petersburg) in 1984. He completed his pathophysiology residency in 1986 at the Pavlov Institute of Experimental Medicine of the Russian Academy of Medical Sciences in St. Petersburg. In 1989, he received a PhD in physiology from the Institute of Physiology of the National Academy of Sciences (Minsk, Belarus). Following postdoctoral training at the University of Tennessee Medical School in Memphis (1991–1994), Dr. Romanovsky accepted the position of Associate Scientist and Director of the Thermoregulation Laboratory at the Legacy Health System in Portland, Oregon (1994–2000). Since 1999, he has been working as Professor at St. Joseph’s Hospital and Medical Center in Phoenix, Arizona, where he directs his basic research laboratory (FeverLab). He also holds an Adjunct Professor appointment at the Arizona State University School of Life Sciences in Tempe, Arizona. Dr. Romanovsky has published more than 100 articles in peer-reviewed scientific journals. His research has been funded by the National Institutes of Health, the State of Arizona, and a number of pharmaceutical companies and foundations. He has served on study sections and reviewed grant applications for the National Institutes of Health, the National Science Foundation, the Medical Research Council (UK), the Canadian Institutes of Health Research, the Swedish Research Council, the Dutch Research Council, the National Research Foundation (South Africa), the National Council of Romania, the Polish National Science Center, the government of Hong Kong, and other agencies in many countries. He has served on boards of multiple journals including the American Journal of Physiology (Regulatory, Integrative and Comparative Physiology), Public Library of Science One (Academic Editor), and Acta Physiologica Hungarica (International Board), and is the founding Editor-in-Chief of the journal Temperature. He is a co-founder of Catalina Pharma, Inc.

Affiliations and Expertise

Professor, Trauma Research, St. Joseph’s Hospital and Medical Center, Phoenix, AZ; Adjunct Professor, School of Life Sciences, Arizona State University, Tempe, AZ, USA