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Thermal Sensors - 1st Edition - ISBN: 9780128001813, 9780128004487

Thermal Sensors, Volume 74

1st Edition

Editors: León Islas Feng Qin
Hardcover ISBN: 9780128001813
eBook ISBN: 9780128004487
Imprint: Academic Press
Published Date: 27th October 2014
Page Count: 394
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Table of Contents

  • Current Topics in Membranes, Volume 74
  • <li>Preface</li> <li>Previous Volumes in Series<ul><li>Current Topics in Membranes and Transport</li><li>Current Topics in Membranes</li></ul></li> <li>Chapter One. Thermal Effects and Sensitivity of&#xA0;Biological Membranes<ul><li>1. Introduction</li><li>2. Response of Organisms to Changes in&#xA0;Temperature</li><li>3. General Thermal Dependence of Membrane Properties</li><li>4. Pyroelectricity</li><li>5. Infra Red Radiation and Capacitance</li><li>6. Activation of Specific Channels by IR</li><li>7. Conclusions</li></ul></li> <li>Chapter Two. Temperature Sensing by&#xA0;Thermal TRP Channels: Thermodynamic Basis and&#xA0;Molecular Insights<ul><li>1. Introduction</li><li>2. Principles of Temperature Activation</li><li>3. Temperature Dependence of Thermal TRP&#xA0;Channels</li><li>4. Kinetics and Energetics of Thermal Channels</li><li>5. Hysteresis of Temperature-Dependent Gating</li><li>6. Heat Capacity Theory</li><li>7. Origins of Thermal Sensitivity</li><li>8. Distribution of Thermal Sensitivity: Global&#xA0;or Local?</li><li>9. Identification of Molecular Basis of&#xA0;Thermal Sensitivity</li><li>10. Summary</li></ul></li> <li>Chapter Three. Gating of Thermally Activated Channels<ul><li>1. Introduction</li><li>2. Temperature-Sensitive Channel Diversity</li><li>3. Energetics of Temperature-Sensitive Channels</li><li>4. Gating Kinetics in ThermoTRP Channels</li><li>5. Molecular Determinants of Temperature Sensing in TRP Channels</li><li>6. CODA</li></ul></li> <li>Chapter Four. TRPA1 Channels: Chemical and&#xA0;Temperature Sensitivity<ul><li>1. Introduction</li><li>2. Activation and Regulation of TRPA1 by Chemical Compounds</li><li>3. Temperature Sensitivity of TRPA1</li></ul></li> <li>Chapter Five. Temperature Sensitivity of Two-Pore (K<sub>2P</sub>) Potassium Channels<ul><li>1. Introduction</li><li>2. Physiological Role of Heat-Activated K<sub>2P</sub>&#xA0;Channels</li><li>3. Molecular Mechanism of Temperature Gating of TREK-1, TREK-2, and TRAAK</li><li>4. Heat- and Mechanosensitivity of K<sub>2P</sub>s: Different Facets of the Same Process?</li><li>5. Future Studies of K<sub>2P</sub> Channel Thermal Sensitivity</li></ul></li> <li>Chapter Six. Lipid Modulation of Thermal Transient Receptor Potential Channels<ul><li>1. Introduction</li><li>2. Phosphatidylinositol 4,5-Bisphosphate (PIP<sub>2</sub>)</li><li>3. GPCR Signaling Pathways</li><li>4. n-3 PUFAs and Derivatives</li><li>5. Oxidized Lipids</li><li>6. Lysophospholipids</li><li>7. Cholesterol and Steroids</li><li>8. Other Lipids</li><li>9. Concluding Remarks</li></ul></li> <li>Chapter Seven. Structure of Thermally Activated TRP Channels<ul><li>1. Introduction</li><li>2. TRP Channels as Thermal Sensors</li><li>3. Outlook and Prospective</li></ul></li> <li>Chapter Eight. Thermal Sensitivity of CLC and&#xA0;TMEM16 Chloride Channels&#xA0;and Transporters<ul><li>1. Introduction</li><li>2. Thermal Nociception</li><li>3. TMEM16A</li><li>4. CLC Proteins</li><li>5. Conclusions</li></ul></li> <li>Chapter Nine. Structure and Function of the ThermoTRP Channel Pore<ul><li>1. Introduction</li><li>2. Structural Features of a ThermoTRP Channel Pore</li><li>3. Functional Tests of Pore Structures</li><li>4. Activation Gating of TRPV1</li><li>5. Pore Dilation</li><li>6. Concluding Remarks</li></ul></li> <li>Chapter Ten. Temperature-Sensitive Gating of Voltage-Gated Proton Channels<ul><li>1. Introduction</li><li>2. Properties and Physiological Functions of&#xA0;Hv</li><li>3. Thermosensitive Functions of Cells Expressing Hv</li><li>4. Temperature Dependence of Native Hv</li><li>5. Molecular Structure of Hv1/VSOP</li><li>6. Thermal Stability of the Coiled-Coil Domain and the Thermal Sensitivity of Hv</li><li>7. Model of Thermosensitive Channel Gating</li></ul></li> <li>Chapter Eleven. Intimacies and Physiological Role of the Polymodal Cold-Sensitive Ion Channel TRPM8<ul><li>1. Introduction</li><li>2. TRPM8, a Cold-Activated Polymodal Ion Channel</li><li>3. Physiological Role of TRPM8</li><li>4. Trafficking, N-glycosylation and Modulation of TRPM8 Channel Function</li><li>5. Conclusions</li></ul></li> <li>Chapter Twelve. Thermally Activated TRPV3 Channels<ul><li>1. Introduction</li><li>2. Expression and Function of TRPV3</li><li>3. TRPV3 activators</li><li>4. TRPV3 Regulators</li><li>5. Conclusions</li></ul></li> <li>Index</li> <li>Color Plates</li>


Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading.

This volume presents an up to date presentation of current knowledge and problems in the field of thermal receptors. This is a rapidly evolving research area and the book contains important contributions from some of the leaders in the field.

Key Features

  • Written by leading experts
  • Contains original material, both textual and illustrative, that should become a very relevant reference material
  • The material is presented in a very comprehensive manner
  • Both researchers in the field and general readers should find relevant and up-to-date information


Professionals working in the field and general physiologists seeking to brush up on the current state of the art in the field of thermal receptors.


No. of pages:
© Academic Press 2014
27th October 2014
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Editors

León Islas

León Islas

Affiliations and Expertise

Departamento de Fisiología, Facultad de Medicina, UNAM, México DF, México

Feng Qin

Feng Qin

Affiliations and Expertise

Department of Physiology & Biophysics, State University of New York, Buffalo, New York, USA