Description

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety.

Key Features

  • Includes both the technical and clinical issues associated with therapeutic drug monitoring
  • Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc.
  • Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants
  • Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Readership

Clinical pathologists, toxicologists, pharmacologists, laboratory professionals and clinical chemists

Table of Contents

Dedication

Preface

Contributors

Chapter 1. Introduction to Therapeutic Drug Monitoring: Frequently and Less Frequently Monitored Drugs

Introduction

Drugs that Require Therapeutic Drug Monitoring

Benefits of Therapeutic Drug Monitoring

Pathophysiological Conditions and other Factors that Affect Drug Concentrations

Therapeutic Drug Monitoring of Various Drug Classes

Conclusions

References

Chapter 2. Effects of Pre-analytical Variables in Therapeutic Drug Monitoring

Introduction

Specimen Type

Factors that Affect Therapeutic Drug Monitoring Results

Protein Binding Alteration: In Vivo and In Vitro

Specimen Collection Site

Volume of Specimen Collected

Glass versus Plastic Tubes for Collection of Blood

Serum versus Plasma Specimen for Therapeutic Drug Monitoring

Suitability of Serum Separator Collection Tubes for Specimen Collection for Drug Monitoring

Sample Preparation Steps

Conclusions

References

Chapter 3. Analytical Techniques used in Therapeutic Drug Monitoring

Introduction

A General Classification of Analytical Methods

Understanding and Minimizing Measurement Uncertainty in the Clinical Laboratory

Immunoassays

Gas and Liquid Chromatography

Mass Spectrometry and LC-MS/MS Application to TDM

Conclusions

References

Chapter 4. Clinical Utility of Free Drug Monitoring

Introduction

Free Concentrations versus Total Concentrations

Pharmacokinetic Consequences of Drug–Protein Binding

Monitoring Free Concentrations of Classical Anti-Epileptics

Monitoring Free Concentrations of Antibiotics, Antimalarials and Antiretrovirals

Monitoring Free Concentrations of Immunosuppressants

Monitoring Free Concentrations of Other Drugs

Applications and Methods f

Details

No. of pages:
468
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123854674
Electronic ISBN:
9780123854681

About the author

Amitava Dasgupta

Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.