- Print ISBN 9780123854674
- Electronic ISBN 9780123854681
Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety.
Includes both the technical and clinical issues associated with therapeutic drug monitoring.
Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc.
Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants.
Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques.
The primary target market for this book includes clinical pathologists, toxicologists, pharmacologists, laboratory professionals and clinical chemists.
Chapter 1. Introduction to Therapeutic Drug Monitoring: Frequently and Less Frequently Monitored Drugs
Drugs that Require Therapeutic Drug Monitoring
Benefits of Therapeutic Drug Monitoring
Pathophysiological Conditions and other Factors that Affect Drug Concentrations
Therapeutic Drug Monitoring of Various Drug Classes
Chapter 2. Effects of Pre-analytical Variables in Therapeutic Drug Monitoring
Factors that Affect Therapeutic Drug Monitoring Results
Protein Binding Alteration: In Vivo and In Vitro
Specimen Collection Site
Volume of Specimen Collected
Glass versus Plastic Tubes for Collection of Blood
Serum versus Plasma Specimen for Therapeutic Drug Monitoring
Suitability of Serum Separator Collection Tubes for Specimen Collection for Drug Monitoring
Sample Preparation Steps
Chapter 3. Analytical Techniques used in Therapeutic Drug Monitoring
A General Classification of Analytical Methods
Understanding and Minimizing Measurement Uncertainty in the Clinical Laboratory
Gas and Liquid Chromatography
Mass Spectrometry and LC-MS/MS Application to TDM
Chapter 4. Clinical Utility of Free Drug Monitoring
Free Concentrations versus Total Concentrations
Pharmacokinetic Consequences of Drug–Protein Binding
Monitoring Free Concentrations of Classical Anti-Epileptics
Monitoring Free Concentrations of Antibiotics, Antimalarials and Antiretrovirals
Monitoring Free Concentrations of Immunosuppressants
Monitoring Free Concentrations of Other Drugs
Applications and Methods f