Therapeutic Applications of Quadruplex Nucleic Acids

Therapeutic Applications of Quadruplex Nucleic Acids

1st Edition - August 31, 2011

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  • Author: Stephen Neidle
  • eBook ISBN: 9780123751393
  • Paperback ISBN: 9780128103722

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Description

The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.

Readership

Biochemists, chemists, professional researchers in laboratories in academic, government and corporate environments studying translational science, medicine and pharmacology, as well as, advanced undergraduate students, graduate students and medical students.

Table of Contents

  • Dedication

    Preface

    1. Introduction

    2. DNA and RNA Quadruplex Structures

    3. The Structures of Human Telomeric DNA Quadruplexes

    4. Telomeric Quadruplex Ligands I

    5. Telomeric Quadruplex Ligands II

    6. The Biology and Pharmacology of Telomeric Quadruplex Ligands

    7. Genomic Quadruplexes as Therapeutic Targets

    8. RNA Quadruplexes

    9. Design Principles for Quadruplex-binding Small Molecules

    10. The Determination of Quadruplex Structures

    Index

Product details

  • No. of pages: 208
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: August 31, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123751393
  • Paperback ISBN: 9780128103722

About the Author

Stephen Neidle

Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Affiliations and Expertise

Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK

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