Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

1st Edition - February 9, 2019

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  • Editors: Lucia Morbidelli, Benjamin Bonavida
  • Hardcover ISBN: 9780128165454
  • eBook ISBN: 9780128172797

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.

Key Features

  • Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions
  • Discusses new ideas proposed and makes suggestions for further investigations that will advance the field
  • Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research


Cancer researchers, medical scientists, clinicians, graduate students

Table of Contents

  • I. Applications of Nitric Oxide in Cancer
    1. Nitric Oxide-Releasing Engineered Nanoparticles: Tools for Overcoming Drug Resistance in Chemotherapy
    2. Reversal of Multiple Cancer Oncogenic Pleiotropic Properties by NO-modulating Therapies
    3. Antitumor Effect of a Metal Nonoate Through Angiogenesis Impairment
    4. Therapeutic Implications of the Nitric Oxide Pathway in the Angiogenesis of Tumors and Inflammatory-Related Disorders
    5. Nitric oxide and cancer: To inhibit or to induce iNOS – That is the Question?
    6. Arginine Metabolism Regulates Nitric Oxide Production in Melanoma Tumor Microenvironment to Provide Survival Advantage to Tumor Cells
    7. Cancer and Beyond: Discovery and Development of NO-releasing Therapeutics
    8. Nitric Oxide Scavenging-Based Therapies for Targeting Colorectal Cancer
    9. Therapeutic Aspects of Protein Denitrosylation
    10. Nitric Oxide-Releasing Functional Nanomaterials for Anticancer Therapy

    II. Applications of Nitric Oxide in Inflammatory-Related Disorders
    11. The Role of Nitric Oxide on Vascular Dysfunction During Aging and Alzheimer’s Disease
    12. Carbonic Anhydrase Inhibitor – NO Donor Hybrids and Their Pharmacologic Applications
    13. Understanding the Roles of Nitric Oxide During Sepsis, an Inflammatory Disorder
    14. Nanoporous Materials: New Generation of Nitric Oxide Donors

    III. Abstracts (Presentations at Conference in Siena, October 4th-5th, 2018)
    A. Serum Nitric Oxide Metabolites and The Incidence of Metabolic Syndrome and Its Phenotypes: A Population-Based Prospective Study
    B. Nitric Oxide (NO): A Multifaceted Target for Reversal of Cancer Cell Pleiotropic Properties by NO-modulating Therapies
    C. Pharmacology of Hepatoselective Nitric Oxide - Donors in NAFLD in Mice
    D. New NO-Releasing Doxorubicins as Targeted Therapy Against Chemoresistance in Castration-resistant Prostate Cancer: In Vitro and In Vivo Evaluations
    E. Anticancer Effect of a Novel H2S-Hybrid Molecule on Human Breast Adenocarcinoma (MFC-7) and Human Breast Epithelial (MCF-10A) Cell Lines
    F. Heme Oxygenase-1 In Duchenne Muscular Dystrophy: Interaction with Nitric Oxide Synthase Pathway in Satellite Cells Differentiation
    G. In Vitro Assessment of NitDox Toxicity Towards Vasculature
    H. The Regulation of GSNOR Expression Discloses the Role of S-nitrosylation in Aging and Disease
    I. Effects of Long-term Nitrite Supplementation on Gene Expressions of GLUT2, GLUT4 and Glucokinase in Male Obese Type 2 Diabetic Rats
    J. Nitric Oxide Re-Instates Doxorubicin Cytotoxic and Pro-Immunogenic Effects in Refractory Breast Cancer
    K. Anti-Cancer Activities of Erucin a H2S-donor Isothiocyanate from Eruca Sativa Mill.: Is H2S the Real Player?
    L. Hydrogen Sulfide as a Signaling Molecule in The Cardiovascular System: Actions and Interactions with NO
    M. Nitric Oxide in Cancer Resistance to Cisplatin: Tumor Associated Macrophages as Key Players.
    N. Therapeutic Potential of Nitric Oxide Modulation in Ocular Diseases: A Focus on Novel NO-Releasing Molecules
    O. Pro-Apoptotic Effects of S-Nitrosothiols O-Chloro and M-Chloro S-Nitroso-Aryl-Amides in Human Breast Cancer Cell Lines
    P. Light Guided Production of Nitric Oxide and Singlet Oxygen for the Multi-Modal Treatment of Cancer
    Q. Potential for Chemoprevention with Nitric Oxide- and Hydrogen Sulfide-Releasing Drugs
    R. H2S Metabolism in Colon Cancer Cells Exposed to Hypoxia

Product details

  • No. of pages: 372
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: February 9, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128165454
  • eBook ISBN: 9780128172797

About the Editors

Lucia Morbidelli

Dr. Morbidelli’s experience is within the molecular and biochemical pharmacology of angiogenesis and microcirculation and its biological application in diseases and cancer. Through of a plethora of in vitro and in vivo models, she has contributed to the characterization of the pro- and antiangiogenic activities of designed synthetic molecules and natural products and their potential applications in angiogenesis-dependent diseases of the cardiovascular system, ocular disorders, neurovascular diseases and cancer. She co-organized with Professor Bonavida the Fourth International Workshop on “Nitric Oxide in Cancer” held in Sevilla in March 13-14, 2015. The meeting addressed different topics such as NO, mutagenesis, carcinogenesis, tumor promotion and tumor growth; NO regulation of cell death pathways; NO and proliferation and epithelial-mesenchymal transition; Regulation of immune response by NO; Antitumoral activity of NO-based releasing strategies: pre-clinical studies; Antitumoral activity of NO-based releasing strategies: clinical trials.

Affiliations and Expertise

Professor, Department of Life Sciences, University of Siena, Siena, Italy

Benjamin Bonavida

Benjamin Bonavida, PhD, has been involved in the field of immunology and cancer biology for several decades and has published extensively in the fields of cancer resistance, chemotherapy, immunotherapy, and various molecular approaches to circumvent the resistance of the cancer cells using sensitizing agents. Accordingly, he was the first to publish a book on tumor sensitization in 2008. More recently, Dr. Bonavida is the Series Editor of 3 series published by Elsevier/Academic Press (“Cancer Sensitizing Agents for Chemotherapy,” “Breaking Cancer Resistance to Therapeutic Antibodies,” and “Breaking Tolerance to Anti-Cancer Immunotherapy”) and several books have been published and many are in development. He has published extensively in the field of NK biology and cytotoxicity in the past, and many of these publications were in collaboration with the co-editor Dr. Anahid Jewett.

Affiliations and Expertise

Professor, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

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