The Zebrafish in Biomedical Research - 1st Edition - ISBN: 9780128124314

The Zebrafish in Biomedical Research

1st Edition

Biology, Husbandry, Diseases, and Research Applications

Editors: Samual Cartner Judith Eisen Susan Farmer Karen Guillemin Michael Kent George Lawrence Sanders
Hardcover ISBN: 9780128124314
Imprint: Academic Press
Published Date: 1st February 2019
Page Count: 550
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Description

A small freshwater fish native to south Asia, the zebrafish (Danio rerio), has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery. The National Institutes of Health recently ranked zebrafish as the third most frequently used developmental model system for Health and Human Services funded research. Zebrafish have become popular in part because of their ability to produce a large number of offspring at low cost, which allows performance of large genetic and molecular screens. The zebrafish genome has been fully sequenced, and protocols are well established for transient or stable transgene expression and other gene manipulations in the species. Both zebrafish embryos and larvae are optically transparent, enabling non-invasive visualization of developing organs and biological processes in vivo at high resolution. Furthermore, zebrafish have come to be used to model a wide variety of human diseases in recent years, and are increasingly used in toxicology testing.

The Zebrafish in Biomedical Research is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text contains four sections: Biology, Husbandry, Diseases, and Research Applications. The audience for this work includes vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using them to gain critical insights into human physiology and disease.

Key Features

  • Complete view of the zebrafish covering their biology, husbandry, diseases and research applications
  • World-renowned editors behind the work
  • The first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM Series

Readership

Vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators/researchers using them to gain critical insights into human physiology and disease

Table of Contents

Introduction
1. History of Zebrafish Research

Biology Section
2. Taxonomy/Phylogeny

Appearance/Morphology/Anatomy and Development/Physiology (Morphophysiology) General appearance/morphology
3. Head and Body
4. Integumentary System
5. Respiratory System
6. Skeletal System
7. Muscular System

Tissues and Organs Associated with Special Senses
8. Vision
9. Mechanosensory Lateral line System
10. Chemoreception
11. Hearing and Vestibular Function

Anatomy and Embryo Development
12. Head and Body
13. Digestive System
14. Cardiovascular System
15. Urinary System
16. Reproductive Systems
17. Endocrine Systems
18. Nervous Systems
19. Physiology, hematology, and clinical chemistry, gas exchange, hormonal regulation, regulatory osmolality
20. Immunology
21. Pigment/Chromophores
22. Sexual characteristics
23. Geographic Range/Natural Distribution
24. Natural History/Ecological Niche
25. Behavior of Wild Populations
26. Genetics

Husbandry Section
27. Introduction to Husbandry
28. Aquatics Facilities Design
29. Housing Types
30. Water Quality: definitions, effects on health, testing, normal values, equipment used, records
31. Filtration: definitions, testing methods, normal values, equipment used, records
32. Systems Maintenance and Troubleshooting: methods, equipment used, records
33. Cleaning and Disinfection of Life Systems: methods, equipment used, records
34. Feeding/Nutrition
35. Breeding/Colony Management
36. Larviculture
37. Importation and Quarantine
38. Exportation and Transport
39. Analgesia, Anesthesia, and Euthanasia
40. Regulatory Oversight, USA and internationally
41. Health Surveillance Programs

Diseases Section
42. Idiopathic and Water Quality Related Diseases
43. Parasitic Diseases: Including Microsporidia
44. Bacterial Diseases: Including Saprolegnia
45. Viral Diseases
46. Neoplasms (naturally occurring, associations with other diseases)
47. Special procedures (for disease diagnosis and treatment)

Research Section
48. Zebrafish as a Model to Understand Vertebrate Development
49. Zebrafish as a Model to Understand Neural Circuitry and Behavior
50. Zebrafish as a Model to Understand Human Genetic Diseases
51. Zebrafish as a Model to Understand Host-Microbe Interactions and Host-Pathogen Interactions
52. Zebrafish as a Model to Understand Regeneration
53. Zebrafish as a Platform for Technology Development
54. Zebrafish as a Platform for Genetic Screening
55. Zebrafish as a Platform for Toxicology and Drug Screening (or split into two)
56. Cancer Research

Details

No. of pages:
550
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128124314

About the Editor

Samual Cartner

Samuel Cartner, D.V. M., Ph.D., is the Assistant Vice President for Animal Research Services and Director of the Animal Resources Program (ARP) at the University of Alabama at Birmingham (UAB). He received his DVM from Auburn College of Veterinary Medicine and PhD from UAB. Dr. Cartner has served in multiple roles with organizations that promote premium laboratory animal care. Dr. Cartner is a faculty member in the Department of Genetics. His research interest includes genetic susceptibility to infectious disease, and the development of animal models of human and animal disease. Recently Dr. Cartner has focused on investigations that lead to improvements of laboratory animal care and use.

Affiliations and Expertise

Assistant Vice President, Animal Research Services and Director, Animal Resources Program (ARP), University of Alabama at Birmingham (UAB)

Judith Eisen

Judith S. Eisen, Ph.D., earned her Doctorate at Brandeis University. She is a professor at the University of Oregon and a member of the Institute of Neuroscience at Oregon. The focus of Eisen’s research is to understand the mechanisms underlying development and function of the vertebrate nervous system. Eisen uses zebrafish in her research.

Affiliations and Expertise

Professor, Institute of Neuroscience, Department of Biology, University of Oregon, Eugene, OR, USA

Susan Farmer

Susan C. Farmer, DVM, Ph.D., is the Senior Clinical Veterinarian and Co-Director of the Zebrafish Research Facility at the University of Alabama. Services offered by the facility are husbandry, larviculture, cryopreservation and research support. Dr. Farmer have her DVM degree from Mississippi State University and her Ph.D. in Pathology/Experimental Pathology from the University of Alabama at Birmingham.

Affiliations and Expertise

Co-Director, Zebrafish Research Facility and Assistant Director, Aquatics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, USA

Karen Guillemin

Karen Guillemin, Ph.D., earned her Doctorate at Stanford University. She is a Professor at the University of Oregon and a member of the Institute of Molecular Biology at Oregon. Dr. Guillemin studies host-microbe interactions in development and disease, and uses zebrafish in her research.

Affiliations and Expertise

Professor, University of Oregon, Eugene, OR, USA

Michael Kent

Michael Kent, Ph.D., is a Professor of Microbiology at Oregon State University in the College of Veterinary Medicine. Kent’s lab focuses on two major research areas: diseases of zebrafish in research facilities and impacts of pathogens on wild salmonid fishes. Dr. Kent is also a co-PI at the Zebrafish International Resource Center where he assists with health studies and their diagnostic service.

Affiliations and Expertise

Professor of Microbiology, Oregon State University, College of Veterinary Medicine, Eugene, OR, USA

George Lawrence Sanders

George E. Sanders D.V.M., M.S. earned his Doctorate in Veterinary Medicine from Louisiana State University’s School of Veterinary Medicine. He received his Masters of Science in Comparative Medicine at the University of Washington. Dr Sanders is a Lecturer and is the Director of the Aquatic Animal Program, which provides multiple resources, training, instruction, and coordinates veterinary care for aquatic research animals at the University of Washington.

Affiliations and Expertise

Senior Lecturer and Director, Aquatic Animal Program, Comparative Medicine, University of Washington, Seattle, WA, USA

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