The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research

Biology, Husbandry, Diseases, and Research Applications

1st Edition - November 22, 2019
This is the Latest Edition
  • Editors: Samuel Cartner, Judith Eisen, Susan Farmer, Karen Guillemin, Michael Kent, George Sanders
  • Hardcover ISBN: 9780128124314
  • eBook ISBN: 9780128124321

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Description

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research.

Key Features

  • Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications
  • Includes the work of world-renowned authors
  • Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Readership

Vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators/researchers using them to gain critical insights into human physiology and disease

Table of Contents

  • I.  Introduction

    1. History of Zebrafish Research

    2. Taxonomy/Phylogeny

    3.  Zebrafish Genetics

    4.  Geographic Range and Natural Distribution

    5.  Behavior of Wild Populations

    II.  Biology

    Appearance, Development, Anatomy, Physiology

    6.  Zebrafish in Biomedical Research: Head and Body: Anatomy

    7.  Establishing the Body Plan: The First 24 Hours of Zebrafish Development

    Organ Systems: Development, Anatomy, Physiology

    8.  Zebrafish Integumentary System

    9.  Zebrafish Pigmentation

    10. Respiratory System

    11. Skeletal System Morphophysiology

    12. Zebrafish Myology

    13. It Takes Guts: Development of the Embryonic and Juvenile Zebrafish Digestive System

    14. The Zebrafish Cardiovascular System

    15. Development of the Zebrafish Pronephric and Mesonephric Kidneys

    16. Reproductive System

    17. Endocrine Systems

    18. Nervous Systems

    19. Immunology

    20. Physiology: Hematology and Clinical Chemistry, Gas Exchange, and Regulatory Osmolality

    Tissues and Organs Associated with Special Senses

    21. Zebrafish in Biomedical Research: The Retina and Vision

    22. The Mechanosensory Lateral Line System

    23. Inner Ear and Hearing

    Husbandry

    24. Introduction to Zebrafish Husbandry

    25. Aquatic Facility Design Considerations: Incorporating Aquatics into an Animal Facility

    26. Aquatic Housing

    27. Cleaning and Disinfection of Life Systems

    28. Zebrafish Aquatic Systems: Preventative Maintenance and Troubleshooting

    29. Water Quality for Zebrafish Cultura

    30. Recirculating Aquaculture Systems (RAS) for Zebrafish Culture

    31. Zebrafish Breeding and Colony Management

    32. Zebrafish Larviculture

    33. Zebrafish Nutrition--Moving Forward

    34. Anesthesia, Analgesia, and Euthanasia of the Laboratory Zebrafish

    35. Health Xurveillance Programs

    36. Importation and Quarantine

    37. Export and Transportation of Zebrafish

    38. Regulations, Policies and Guidelines Pertaining to the Use of Zebrafish in Biomedical Research

    III. Diseases

    39. Water Quality and Idiopathic Diseases of Laboratory Zebrafish

    40. Important Parasites of Zebrafish in Research Facilities

    41. Bacterial and Fungal Diseases of Zebrafish

    42. Viral Diseases

    43. Nonexperimentally Induced Neoplastic and Proliferative Lesions in Laboratory Zebrafish

    44. Special Procedures for Zebrafish Diagnostics

    45. Zebrafish as a Model to Understand Vertebrate Development

    46. Zebrafish as a Model for Revealing the Neuronal Basis of Behavior

    47. Zebrafish as a Model to Understand Human Genetic Diseases

    48. Zebrafiish as a Model for Investigating

    49. Targeted Editing of Zebrafish Genes to Understand Gene Function and Human Disease Pathology

    50. Zebrafish as a Platform for Genetic Screening

    51. Zebrafish as a Platform for Drug Screening

     

     

Product details

  • No. of pages: 718
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: November 22, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128124314
  • eBook ISBN: 9780128124321

About the Editors

Samuel Cartner

Samuel Cartner, D.V. M., Ph.D., is the Assistant Vice President for Animal Research Services and Director of the Animal Resources Program (ARP) at the University of Alabama at Birmingham (UAB). He received his DVM from Auburn College of Veterinary Medicine and PhD from UAB. Dr. Cartner has served in multiple roles with organizations that promote premium laboratory animal care. Dr. Cartner is a faculty member in the Department of Genetics. His research interest includes genetic susceptibility to infectious disease, and the development of animal models of human and animal disease. Recently Dr. Cartner has focused on investigations that lead to improvements of laboratory animal care and use.

Affiliations and Expertise

Assistant Vice President, Animal Research Services and Director, Animal Resources Program (ARP), University of Alabama at Birmingham (UAB)

Judith Eisen

Judith S. Eisen, Ph.D., earned her Doctorate at Brandeis University. She is a professor at the University of Oregon and a member of the Institute of Neuroscience at Oregon. The focus of Eisen’s research is to understand the mechanisms underlying development and function of the vertebrate nervous system. Eisen uses zebrafish in her research.

Affiliations and Expertise

Professor, Institute of Neuroscience, Department of Biology, University of Oregon, Eugene, OR, USA

Susan Farmer

Susan C. Farmer, DVM, Ph.D., is the Senior Clinical Veterinarian and Co-Director of the Zebrafish Research Facility at the University of Alabama. Services offered by the facility are husbandry, larviculture, cryopreservation and research support. Dr. Farmer have her DVM degree from Mississippi State University and her Ph.D. in Pathology/Experimental Pathology from the University of Alabama at Birmingham.

Affiliations and Expertise

Co-Director, Zebrafish Research Facility and Assistant Director, Aquatics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, AL, USA

Karen Guillemin

Karen Guillemin, Ph.D., earned her Doctorate at Stanford University. She is a Professor at the University of Oregon and a member of the Institute of Molecular Biology at Oregon. Dr. Guillemin studies host-microbe interactions in development and disease, and uses zebrafish in her research.

Affiliations and Expertise

Professor, University of Oregon, Eugene, OR, USA

Michael Kent

Michael Kent, Ph.D., is a Professor of Microbiology at Oregon State University in the College of Veterinary Medicine. Kent’s lab focuses on two major research areas: diseases of zebrafish in research facilities and impacts of pathogens on wild salmonid fishes. Dr. Kent is also a co-PI at the Zebrafish International Resource Center where he assists with health studies and their diagnostic service.

Affiliations and Expertise

Professor of Microbiology, College of Veterinary Medicine, Oregon State University, Eugene, OR, USA

George Sanders

George E. Sanders, DVM, M.S., is certified as a Fish Pathologist by the American Fisheries Society Fish Health Section, a Senior Lecturer, and the Aquatic Animal Program Director for the Department of Comparative Medicine at the University of Washington. He provides multiple resources, program development, facility and systems design, training, instruction, regulatory compliance, and coordinates veterinary care and pathology for all aquatic research animals. Dr. Sanders received his DVM from Louisiana State University School of Veterinary Medicine and his Masters of Science in Comparative Medicine from the Department of Comparative Medicine at the University of Washington.

Affiliations and Expertise

Senior Lecturer and Aquatic Animal Program Director, University of Washington, School of Medicine, Department of Comparative Medicine, Seattle, WA USA

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  • AlmutKoehler Wed Jan 29 2020

    The Zebrafish in Biomedical Research

    The Zebrafish in Biomedical Research

  • AlexandriaHudson Sun Dec 15 2019

    Love it!

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