The Vasculome

The Vasculome

From Many, One

1st Edition - June 1, 2022

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  • Editor: Zorina Galis
  • Paperback ISBN: 9780128225462

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Description

The Vasculome: From Many, One introduces the fundamental bases of the “unity in diversity” of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section.

Key Features

  • Brings together leading experts who present the latest biomedical thinking about the vasculature from the integrative perspective of the Vasculome
  • Challenges traditional real and perceived boundaries within vascular research areas and stimulates new fundamental thinking and medical explorations
  • Creates the bases for translating the integrative Vasculome concept into improved fundamental and clinical assessment and management of local and systemic contributions of the vasculature in health and disease

Readership

Basic and clinical researchers within various areas of Vascular Biology, Medicine and Cardiology; as well as researchers who need to understand the vasculome concept such as in fields of neuroscience, genetics, physiology, or pharmacology

Table of Contents

  • PART I. THE ARCHITECTURAL DESIGN OF THE VASCULOME:  BASIS FOR SYSTEM-WIDE FUNCTIONAL UNITY AND LOCAL DIVERSITY
    SECTION 1. The Endothelium: Key Unifying Principle of the Vasculome. Basis for Systemic Unity and for Engineering of Local Specialization
       
    1. Developmental of, and environmental impact on, endothelial cell diversity
    2. Endothelial cell heterogeneity in health and disease – new insights from single cell studies

    SECTION 2. Vasculome’s Key Building Blocks - Beyond the Endothelium
    3.  The Remarkable Diversity of Vascular Smooth Muscle in Development and Disease: A paradigm for mesenchymal cell types
    4. SMC contractile diversity
    5. Resident vascular immune cells in health and atherosclerotic disease
    6. Perivascular adipose tissue (physiology, pathology)
    7. Major vascular ECM components, differential distribution supporting structure and functions of the Vasculome

    SECTION 3. Putting it all Together: Integration across Body Scales and within Tissues 
    8. Out to the Tissues: The Arterial Side (Arteries, Arterioles - Development, Structure, Functions, Pathologies)
    9. Capillary diversity: endothelial cell specializations to meet tissue metabolic needs
    10. The neurovascular unit and blood-CNS barriers in health and disease
    11. Lymphatic biology and medicine

    PART II. INVESTIGATING THE VASCULOME:  CONTEXT-DRIVEN METHODS, USES AND LIMITATIONS
    SECTION 1. Experimental and Computational Studies of the Vasculome

    12. The Flow-dependent Endotheliome: Hemodynamic Forces,  Genetic Programs, and Functional Phenotypes
    13. Intravital photoacoustic microscopy of microvascular function and oxygen metabolism’
    14. Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
    15. Simulation of blood flow and oxygen transport in vascular networks
    16. Clinical Investigations of vascular function

    SECTION 2. Realizing the Promise of New High Content Technologies
    17. Angiodiversity – A tale retold by comparative transcriptomics
    18. Using Pattern Recognition and Discriminant Analysis of Functional Perfusion Data to Create “Angioprints” for Normal and Perturbed Angiogenic Microvascular Networks
    19. Artificial Intelligence (AI) for the Vasculome

    PART III. VASCULOME DYNAMICS: IN HEALTH AND IN SICKNESS
    SECTION 1. Cooperating during Development and Organogenesis to Create Vasculome Diversity
    20. Vascular Development and Organogenesis: Depots of Diversity among Conduits of Connectivity Define the Vasculome
    21. Normal Vascular Identity (arteries, veins, lymphatics) and malformations
    22. Sprouting Angiogenesis in Vascular and Lymphatic development

    SECTION 2. Physiological and Pathological Remodeling of the Vasculome
    23. Enablers and drivers of vascular remodeling
    24. Extracellular Matrix Dynamics and Contribution to Vascular Pathologies
    25. Lymphatic vasculature anomalies and dysfunction

    PART IV. THE VASCULOME AS PERPETRATOR AND VICTIM IN LOCAL AND SYSTEMIC DISEASES
    26. Endothelial dysfunction: basis for many local and systemic conditions
    27. The vascular phenotype in hypertension
    28. Functional roles of lymphatics in health and disease
    29. Extracellular Matrix Genetics of Thoracic and Abdominal Aortic Diseases
    30. Peripheral arterial disease (pathophysiology, presentation, prevention/management)
    31. Venous Diseases Including Thromboembolic Phenomena

    PART V. THE VASCULOME IN DIAGNOSIS, PREVENTION, AND TREATMENT OF OTHER DISEASES
    32. Targeting vascular zip codes: from combinatorial selection to drug prototypes
    33. Angiosome concept for vascular interventions
    34. RNA therapies for cardiovascular disease
    35. The Brain Vasculome: An Integrative Model for CNS Function and Disease

    PART VI. Looking Forward Toward "Precision Health" for the Vasculome
    36. Defining and Optimizing Vascular health
    37. The Vasculome provides a Body-wide Cellular Positioning System and Functional Barometer. The “Vasculature as Common Coordinate Frame (CCF)” Concept 

     

Product details

  • No. of pages: 335
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: June 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128225462

About the Editor

Zorina Galis

Dr. Zorina Galis has been a life-long vascular researcher, recognized thought leader, innovator, highly cited researcher, mentor, and a popular science educator. She was educated in physics, biophysics, cell biology, pathology, and vascular medicine at the University of Bucharest, Romania, the McGill School of Medicine, Montreal, Canada, and the Harvard School of Medicine, Boston, USA. A prominent feature of Dr. Galis’ career has been to capitalize on her own transdisciplinary training and experience to identify and pursue major scientific and implementation challenges requiring a diversity of expertise. She has created, mentored, and led such teams, first, in academic medicine, as a tenured professor of Medicine/Cardiology and Biomedical Engineering at Emory School of Medicine and the Georgia Institute of Technology, then, as a Cardiovascular pharmaceutical industry executive at Eli Lilly and Company, and, currently, at the National Institutes of Health (NIH). Her best known research works are related to pioneering hypotheses about the molecular bases of acute cardiovascular conditions, which have led to the development of new diagnostic and therapeutic interventions (Google Scholar) https://scholar.google.com/citations?user=Qwwqn60AAAAJ&hl=en Since joining the in 2011 as the Chief of the Vascular Biology and Hypertension Branch in the National Heart Lung and Blood Institute (NHLBI), Dr. Galis has continued to create and lead wide partnerships dedicated to enhancing fundamental vascular knowledge and its translation, including the Trans-NIH Small Blood Vessels in Health and Disease and the Trans-NIH Lymphatic Coordination Committee, and has spearheaded funding opportunities, including the NHLBI Vascular Interventions/Innovations and Therapeutic Advances (VITA) Program and the NIH Common Fund Human BioMolecular Atlas Program (HuBMAP), both recognized with NHLBI and NIH Director Collaboration Awards. She serves on external professional advisory boards, and is a proud North American Vascular Biology Organization founding member and past Councilor. Of note: Contributions by Zorina Galis, Ph.D, to “The Vasculome” book have been provided in a personal capacity and do not necessarily reflect the opinions or endorsement of the National Institutes of Health (NIH), Department of Human Health Services (HHS).

Affiliations and Expertise

Vascular Researcher, Editor, The Vasculome. Bethesda, MD, United States

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