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The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology - 1st Edition - ISBN: 9780128144510, 9780128144527

The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology

1st Edition

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Editor: Fernando Cobo
Paperback ISBN: 9780128144510
eBook ISBN: 9780128144527
Imprint: Academic Press
Published Date: 9th August 2018
Page Count: 298
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The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems.

Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities.

Key Features

  • Presents updated applications of MALDI-TOF techniques in clinical microbiology
  • Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control
  • Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications
  • Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers


Microbiologists, infectologists, laboratory technicians, postgraduate and postdoctoral researchers

Table of Contents

  1. Proteomics: technology and applications
    2. Basis on mass spectrometry. Technical variants
    3. MALDI-TOF commercial platforms for microbial identification
    4. Work procedures in MALDI-TOF technology
    5. Indications, interpretation of results, advantages, disadvantages and limitations of MALDI-TOF
    6. Quality control in MALDI-TOF techniques
    7. Application of MALDI-TOF for bacterial identification
    8. Detection of bacterial resistance through MALDI-TOF technology
    9. Direct identification of pathogens from positive blood cultures by MALDI-TOF technology
    10. Use of MALDI-TOF techniques in the diagnosis of urinary tract pathogens
    11. Direct application of MALDI-TOF mass spectrometry to cerebrospinal fluid for pathogen identification
    12. Application of MALDI-TOF in clinical virology
    13. Use of MALDI-TOF mass spectrometry in microbacterial diagnosis
    14. Use of MALDI-TOF mass spectrometry in fungal diagnosis
    15. Application of MALDI-TOF in bacterial strain typing and taxonomy
    16. Future applications of MALDI-TOF mass spectrometry in clinical microbiology


No. of pages:
© Academic Press 2018
9th August 2018
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editor

Fernando Cobo

Dr Fernando Cobo is a specialist in microbiology working in the Microbiology Department of the Hospital de Poniente, Spain, and has previously worked at the University Hospital Virgen de las Nievas and the Stem Cell Bank of Andalucía. He is a member of several professional societies including the Spanish Society of Infectious Diseases and Clinical Microbiology, and has published over 50 peer-reviewed journal articles, 10 books, 90 book chapters, and 120 national and international conference papers.

Affiliations and Expertise

Hospital de Poniente, Spain

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