Description

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Key Features

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Readership

Researchers and students in cell, molecular and developmental biology

Table of Contents

Section I: New Approaches to Studying UPR and Cell Stress

  1. CFTR Expression Regulation by the Unfolded Protein Response
  2. Rafal Bartoszewski, Andras Rab, Lianwu Fu, Sylwia Bartoszewska, James Collawn and Zsuzsa Bebok

  3. GRP78/BiP Chapter: Modulation of GRP78/BiP in Altering Sensitivity to Chemotherapy
  4. Thomas C. Chen

  5. Targeting the Unfolded Protein Response in Cancer Therapy
  6. Marina V. Backer, Joseph M. Backer & Prakash Chinnaiyan

  7. Large-scale analysis of UPR-mediated apoptosis in human cells
  8. Andrew M. Fribley, Justin R. Miller, Tyler E. Reist1, Michael U. Callaghan and Randal J. Kaufman

  9. Quantitative Analysis of amino acid oxidation markers by tandem mass spectrometry
  10. Anuradha Vivekanandan-Giri, Jaeman Byun and Subramaniam Pennathur

  11. Animal models in the study of the unfolded protein response
  12. Hemamalini Bommiasamy and Brian Popko

  13. Measurement of Fluoride-induced Endoplasmic Reticulum Stress Using Gaussia luciferase
  14. Ramaswamy Sharma, Masahiro Tsuchiya, Bakhos A. Tannous and John D. Bartlett

  15. Analysis of nelfinavir-induced endoplasmic reticulum stress
  16. Ansgar Brüning

  17. Using temporal genetic switches to synchronize the unfolded protein response in cell populations in vivo
  18. Alexander Gow

  19. Glycoprotein maturation and the UPR
  20. Andreas J. Hülsmeier, Michael Welti and Thierry Hennet

  21. Monitoring and Manipulating Mammalian Unfolded Protein Response
  22. Nobuhiko Hiramatsu, Victory T. Joseph and Jonathan H. Lin

  23. A screen for mutants requiring activation of the unfolded protein response for viability
  24. Guillaume Thibault and Davis T.W. Ng

  25. Signalling Pathways of Proteostasis Network Unreveale

Details

No. of pages:
464
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
Print ISBN:
9780123859280
Electronic ISBN:
9780123859297