Description

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Key Features

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.

Readership

Researchers and students in cell, molecular and developmental biology

Table of Contents

Section I: UPR and Cell Stress in Normal and Diseased Cells

  1. The Unfolded Protein Response in Mouse Cerebral Cortex
  2. Nirinjini Naidoo

  3. Immunohistochemical Detection of the Unfolded Protein Response in Atherosclerotic Plaques
  4. Šárka Lhoták and Richard C. Austin

  5. The role of PDI as a survival factor in cardiomyocyte ischemia
  6. Stefano Toldo; Anna Severino; Antonio Abbate; Alfonso Baldi

  7. Measurement of the Increase in Endoplasmic Reticulum Stress-Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
  8. Guenther Boden and Salim Merali

  9. Measurement of the unfolded protein response (UPR) in monocytes
  10. Tomás P. Carroll, Catherine M. Greene, and Noel G. McElvaney

  11. Assessment of Endurance Exercise Training in Hepatic Endoplasmic Reticulum (ER) Stress
  12. Natalie Ann Chapados

  13. Discovery approaches to UPR in athero - susceptible endothelium in vivo
  14. Mete Civelek, Elisabetta Manduchi, Gregory Grant, Christian J. Stoeckert Jr, Peter F. Davies

  15. Assessment of endoplasmic reticulum stress and the unfolded protein response in endothelial cells
  16. Ines Witte & Sven Horke

  17. Measuring the impact of cigarette smoke on the UPR
  18. Hong Zhao, Jin Yang, Lin Shan and Ellen D. Jorgensen

  19. Induction and measurement of UPR and osmotic stress in the yeast Pichia pastoris
  20. Martin Dragosits, Diethard Mattanovich and Brigitte Gasser

  21. Induction of ER stress response leading to programmed cell death in Trypanosoma brucei
  22. Hanoch Goldshmidt and Shulamit Michaeli

  23. Measurement of Activation of the Endoplasmic Reticulum Stress Response in Autoimmune Myositis
  24. Heather M. Alger, Sree Rayavarapu and Kanneboyina Nagara

Details

No. of pages:
432
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
eBook ISBN:
9780123851178
Print ISBN:
9780123851161

About the editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA

Reviews

This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights.