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The Transformed Cell - 1st Edition - ISBN: 9780121571603, 9780323162968

The Transformed Cell

1st Edition

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Editor: Ivan Cameron
eBook ISBN: 9780323162968
Imprint: Academic Press
Published Date: 1st January 1981
Page Count: 452
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The Transformed Cell deals with many of the differences that may exist between transformed cells and their normal counterparts. Topics covered range from malignancy and the cell surface to cell cycle regulation in normal and transformed cells; phenotypic expression of malignant transformation and its relationship to energy metabolism; and virus-induced transformation. The involvement of cyclic nucleotides in transformation is also discussed, together with intracellular pH and growth control in eukaryotic cells. This book is comprised of 12 chapters and begins with a brief description of terminology and basic concepts relating to cancer cells, as well as some comments on tumorigenicity and cell transformation. The next two chapters explore the evidence for and against the possible correlation of in vivo tumorigenicity to in vitro changes in the cytoskeletal system; anchorage-dependent growth; plasminogen activator production; agglutinability by lectins; and cell surface and plasma membrane properties. The regulation of cell proliferation and the relationships between ion movement and energy metabolism in normal and transformed cells are then examined, along with the transformation of normal cells by infection with new genetic material from tumor viruses. The remaining chapters focus on selected cellular properties that have been purported to differ between the normal and transformed cell, with particular reference to cyclic nucleotides; polyamine metabolism; cell viscosity; mobility of cellular water; intracellular pH; and element concentration. This monograph will be of interest to biologists and medical practitioners devoted to understanding cancer cell biology and cancer therapy.

Table of Contents

List of Contributors


1 The Transformed Cell: Some Introductory Comments

I. Elementary Background, Terms, and Concepts

II. Comments on Tumorigenicity and Cell Transformation


2 Malignant Transformation: In Vivo Methods and in Vitro Correlates

I. Introduction

II. In Vivo Assays of Tumorigenicity

III. Cellular Morphology

IV. Anchorage Dependence

V. Agglutinability by Concanavalin A

VI. Plasminogen Activator

VII. Conclusions


3 Malignancy and the Cell Surface

I. Membrane Structure and Function: An Overview

II. Membrane Changes in Malignant Cells

III. Cancer Chemotherapeutic Applications of Membrane Research

IV. Conclusions


4 Cell Cycle Regulation in Normal and Transformed Cells

I. Introduction

II. Proliferation Kinetics in Normal and Transformed Cells

III. Effect of Serum Factors on Growth of Normal and Transformed Cells

IV. Intracellular Factors Involved in Regulation of Cell Growth

V. Conclusion


5 Phenotypic Expression of Malignant Transformation and Its Relationship to Energy Metabolism

I. Introduction

II. Control of Aerobic Glycolysis by Energy Utilization

III. Cell Transformation and Phenotypic Expression of Energy Metabolism

IV. Summary, Conclusions, and Future Directions of Energy Metabolism of Neoplasia


6 Virus-Induced Transformation

I. Introduction

II. Groups of Transforming Viruses

III. Mechanisms of Initiation and Maintenance of Transformation

IV. Factors in Initiation, Selection, and Tumorigenesis of Transformants

V. Induction and Rescue of Viruses from Transformed and Tumor Cells

VI. Cell Fusion and Cellular Regulation of Transformation and Tumorigenicity

VII. The Validity and Utility of Virus Transformation Models


7 Involvement of Cyclic Nucleotides in Transformation

I. Introduction

II. Low Levels of Cyclic Nucleotides in Transformed Cells

III. High Levels of Cyclic Nucleotides in Transformed Cells

IV. Cyclic Nucleotides and Expression of Normal Phenotype in Transformed Cells

V. Cyclic Nucleotides and Growth of Transformed Cells

VI. Adenylate Cyclase in Transformed Cells

VII. Adenylate Cyclase in Differentiated Transformed Cells

VIII. Cyclic Nucleotide Phosphodiesterase in Transformed Cells

IX. Cyclic Nucleotide-Binding Proteins and Cyclic Nucleotide-Dependent Protein Kinases in Transformed Cells

X. Role of cAMP-Binding Proteins on Survival and Growth

XI. Possible Relationship of cAMP-Binding Proteins with Malignancy

XII. Regulation of cAMP-Binding Proteins

XIII. Significance of cAMP-Binding Proteins

XIV. Phosphoprotein Phosphatase in Transformed Cells

XV. Conclusion


8 Role of Polyamines in the Regulation of the Cell Cycle in Normal and Transformed Mammalian Cells

I. Introduction

II. Polyamines during Growth and Development

III. Polyamine Synthesis in Normal and Transformed Cells

IV. Polyamines and the Cell Cycle of Mammalian Cells

V. Inhibitors of Polyamine Biosynthesis and Their Usefulness in Understanding the Role of Polyamines in Cell Cycle Regulation of Normal and Transformed Cells

VI. Conclusions


9 Distinction of Normal, Preneoplastic, and Neoplastic Mouse Mammary Cells and Tissues by Nuclear Magnetic Resonance Techniques

I. Introduction

II. The "Systemic Effect" of Transformed Cells on Properties of Water in Other Tissues and Serum

III. Distinction of Normal, Preneoplastic, and Neoplastic Tissues by NMR Water Properties

IV. Distinction of Normal, Preneoplastic, and Neoplastic Mouse Mammary Primary Cell Cultures by Water NMR Relaxation Times


10 Spin Label Viscosity Studies of Mammalian Cell Cytoplasm

I. Introduction

II. Methods

III. Results and Discussion

IV. Conclusions


11 Intracellular pH and Growth Control in Eukaryotic Cells

I. Introduction

II. Physiology of Intracellular pH Regulation

III. Extracellular pH

IV. The Cell Cycle

V. Intracellular pH of Tumors In Situ

VI. Glycolysis

VII. Sea Urchin Egg Activation

VIII. Interaction of Intracellular pH with Other Pleiotropic Factors

IX. Conclusions


12 Intracellular Sodium and Growth Control: A Comparison of Normal and Transformed Cells

I. Introduction

II. Measurements of Intracellular Elemental Concentrations by Energy Dispersive X-Ray Microanalysis

III. Intracellular Elemental Concentrations and Cell Division

IV. The Role of Sodium in Growth Stimulation of Normal and Tumor Cells

V. Conclusions




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© Academic Press 1981
1st January 1981
Academic Press
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Ivan Cameron

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