This volume came out of discussions with Professeur Michel Fardeau my long-time colleague in Paris and now Directeur of the Institut de Myologie at the Hopital Pitie-Salpetriere there, and Professeur Emeritus Rene Couteaux, Universite de Paris VI. During my sabbatical year 1994-95, as Professeur de L'Academie des Sciences and Chaire Elf Aquitaine in Paris, Professeur Couteaux and I had a number of discussions, centering on the development of the field of synaptology from his perspective as one who had experienced many of the significant advances during his active professional career. Following these discussions, my colleagues, Daniel Hantai in Paris, and Bruce Citron in Kansas City, and I began to contact scientists in various areas of current synapse research. The result in this volume which seeks to incorporate studies in development, maintenance, and disease states. The foreword by Professeur Couteaux is a remarkable personal journey through the beginnings of this field up to the present day. Professeur Couteaux has continued to be active in his own research on the neuromuscular synapse to this day.

Table of Contents

Contents. List of Contributors. Foreword. Preface. CGRP and the Neuromuscular Junction (T. Lorno). Control of Nerve Sprouting at the Neuromuscular Junction by Extrinsic Local Signals and Intrinsic Neuronal Components (P. Caroni). Remodeling and Elimination of Neuromuscular Synapses (A.A. Herrera). Changes in the Distribution of Synapse Specific Molecules at the Neuromuscular Junction Upon Synaptic Retraction (M.J. Werle). A Model of Developmental Synapse Elimination in the Central Nervous System: Possible Mechanisms and Functional Consequences (A.M. Lohof, Y. Bailly, N. Delhaye-Bouchaud, and J. Mariani). Synaptic Aspects of the Cellular Prion Protein (J. Fournier, F. Escaig-Haye, T. Billette de Villerneur, and O. Robain). Molecular Modification of Neural Networks: Altering Synaptic Function through the use of Viral Mediated Gene Transfer (M.W. Halterman and H.J. Federoff). Multiple Nicotinic Receptor Subtypes and their Roles on Individual Neurons (W.G. Conroy, Z. Zhang, and D.K. Berg). Neurotransmitter Release and Synaptic Plasticity (E.P. Huang and C.F. Stevens). Recording Membrane Currents from Presynaptic Nerve Terminals (A. Mallart). Peptidergic Modulation of Synaptic Transmission in a Rhythmic Motor System (E. Marder, J.C. Jorge-Rivera, V. Kilman, and J.M. Weimann). Neonatal Myasthenia Gravis: Clinical and Pathophysiological Aspects (B. Eynard). Marine Toxins Affecting Quantal Acetylcholine Release and Transmission at the vertebrate Neuromuscular Junction (J. Molgo, F.A. Meunier, C. Colasante, and B. Poulain). Cellular and Molecular Mode of Action of Botulinum and Tetanus Neurotoxins (B. Poulain, F. Doussau, C. Colasante, F. Deloye, and J. Molgo). Disorders of the Human Neuromuscular Junction (A. Vincent). Shifts in the Thrombin: Protease Nexin I Balance in Postnatal and Degenerative Synapse Elimination (B.W. Festoff, B.A. Citron, and I.V. Smirnova). Index.


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Elsevier Science
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