This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments.
@introbul:Key Features @bul:* Presents unique advantages of SV40 as an experimental system for the study of classes of anticancer drugs
- Details new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication
- Provides details to help the reader design and interpret similar experiments
Ideal for researchers, clinicians, specialists, and graduate and upper-level graduate students interested in DNA replication.
- No. of pages:
- © Academic Press 1996
- 3rd April 1996
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Dr. Snapka is an associate professor of Radiology at The Ohio State University, teaching courses in Radiation Biology, DNA Tumor Viruses, Drug Resistance, and Genetic Instability. Dr. Snapka earned his B.S. in Biology and M.S. in Chemistry at North Texas State University. He earned his Ph.D. at the University of California, Irvine and worked as a Research Fellow at the University of California, Berkeley and Massachusetts Institute of Technology. He is the author of over 35 article in refereed journals and is currently conducting research in anticancer drug resistance and drug discovery.
The Ohio State University, Columbus, U.S.A.