Description

This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments.

Key Features

@introbul:Key Features @bul:* Presents unique advantages of SV40 as an experimental system for the study of classes of anticancer drugs * Details new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication * Provides details to help the reader design and interpret similar experiments

Readership

Ideal for researchers, clinicians, specialists, and graduate and upper-level graduate students interested in DNA replication.

Table of Contents

R.M. Snapka, Papovavirus Models for Mammalian Replicons. R.M. Snapka, Analysis of SV40 DNA Replication Intermediates. R.M. Snapka, Catastrophic Failure of DNA Replication Forks: Structural and RecombinationalPathways. R.M. Snapka and E.F. Yamasaki, Topoisomerase II and the Termination of DNA Replication. R.M. Snapka, DNA Damaging Agents. R.M. Snapka, C.A. Ferrar, N.-J. Sun, and J.M. Cassady, Drug Discovery and Evaluation with SV40. L.H. Malkas, Simian Virus 40 (SV40) in Vitro DNA Replication: A Potential Model for Studying Anticancer Drug Action. R.M. Snapka and P.A. Permana, SV40 Circular Oligomer Series: Normal and Abnormal DNA Replication. Subject Index.

Details

No. of pages:
193
Language:
English
Copyright:
© 1996
Published:
Imprint:
Academic Press
Print ISBN:
9780126536300
Electronic ISBN:
9780080550183

About the editor

Robert Snapka

Dr. Snapka is an associate professor of Radiology at The Ohio State University, teaching courses in Radiation Biology, DNA Tumor Viruses, Drug Resistance, and Genetic Instability. Dr. Snapka earned his B.S. in Biology and M.S. in Chemistry at North Texas State University. He earned his Ph.D. at the University of California, Irvine and worked as a Research Fellow at the University of California, Berkeley and Massachusetts Institute of Technology. He is the author of over 35 article in refereed journals and is currently conducting research in anticancer drug resistance and drug discovery.

Affiliations and Expertise

The Ohio State University, Columbus, U.S.A.