The Structure and Function of Nervous Tissue V2

The Structure and Function of Nervous Tissue V2

Structure I

1st Edition - January 1, 1972

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  • Editor: Geoffrey Bourne
  • eBook ISBN: 9780323145886

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The Structure and Function of Nervous Tissue, Volume IV: Physiology II and Biochemistry II focuses on the structure and function of nervous tissue. It investigates the plasticity of synapses, their degeneration and regeneration, neuronal inclusions, RNA of nervous tissue, and molecular organization of neural information processing. Furthermore, it covers topics on gamma-aminobutyric acid (GABA) in the nervous system, the blood-brain barrier, and the extracellular space (ECS) in the vertebrate central nervous system (CNS). Organized into 10 chapters, this volume begins with an overview of synapses, with emphasis on changes in both the efficacy of individual synapses and the numbers of synapses made by axons upon neurons. It then discusses the orthograde terminal degeneration of synapses and the use of light and electron microscopy in studying synapse degeneration and regeneration. It also explains the synthesis, storage, and release of acetylcholine from nerve terminals; inclusions associated with viral infections; metabolism of RNA in nervous tissue; chemical correlates of information processing; metabolism of GABA in mammalian CNS; electrical activity of the normal brain; and chemistry of the cerebrospinal fluid. The book concludes with a chapter on the mechanism by which vertebrate central nervous tissue alters the magnitude of the ECS. This book will be of interest to anatomists, embryologists, biochemists, pathologists, clinicians, and molecular biologists. This will be invaluable as well to graduate students in a variety of disciplines and those specializing in particular aspects of nervous tissue study.

Table of Contents

  • Contributors


    Contents of Other Volumes

    1. Plasticity of Synapses

    I. Introduction

    II. Short-Term Functional Studies

    III. Short-Term Structural Studies

    IV. Trophic Effects at Synapses

    V. Long-Term Functional Studies

    VI. Long-Term Structural Studies

    VII. Conclusions


    2. Degeneration and Regeneration of Synapses

    I. Introduction

    II. Degeneration of Synapses

    III. Regeneration of Synapses

    IV. Summary


    3. Synthesis, Storage, and Release of Acetylcholine from Nerve Terminals

    I. Acetylcholine Synthesis

    II. Acetylcholine Storage

    III. Transmitter Release


    4. Neuronal Inclusions

    I. Introduction

    II. Inclusions Associated with Viral Infections

    III. Nonviral Nuclear Inclusions

    IV. Nonviral Cytoplasmic Inclusions

    V. Inclusions Derived from Neuronal Fibrous Proteins


    5. Ribonucleic Acid of Nervous Tissue

    I. General Aspects of RNA in Nervous Tissue

    II. RNA Metabolism

    III. Induced Changes in RNA

    IV. Special Considerations


    6. Molecular Organization of Neural Information Processing

    I. Introduction

    II. Chemical Correlates of Information Processing

    III. Bioassays for the Molecular Code

    IV. Molecular Basis of Neural Coding

    V. Concluding Remarks


    7. ?-Aminobutyric Acid in the Nervous System

    I. Introduction

    II. Early History

    III. Crustacean Neuromuscular Junction

    IV. Other Invertebrate Inhibitory Synapses

    V. Inhibitory Action of GABA in Nonmammalian Vertebrates

    VI. Inhibitory Synapses in Deiters Nucleus

    VII. Other Inhibitory Synapses in Mammalian CNS

    VIII. Metabolism of GABA in Mammalian CNS

    IX. Other Amino Acids Related to GABA

    X. General Comments and Conclusion


    8. The Electrical Activity of the Normal Brain

    I. Introduction—The Phenomenon as Observed

    II. The EEG of Normal Man

    III. Neuronal Mechanisms Underlying the EEG

    IV. The Effect of Peripheral Stimulation on the Electrical Activity of the Brain

    V. Neuronal Mechanisms Underlying the Evoked Potential

    VI. Summary


    9. The Blood-Brain Barrier

    I. Introduction

    II. Drainage of the Cerebrospinal Fluid—Arachnoid Villi

    III. The Secretion of the Cerebrospinal Fluid—Choroid Plexuses

    IV. Chemistry of the Cerebrospinal Fluid

    V. Rate of Secretion of Cerebrospinal Fluid

    VI. Passage of Infused Material from Blood to Cerebrospinal Fluid

    VII. Penetration into Brain

    VIII. Permeability of the Choroid Plexus

    IX. Slowly Equilibrating Substances

    X. Extracellular Space of Brain

    XI. Brain-Cerebrospinal Fluid Exchanges

    XII. Active Transport Outwards

    XIII. Morphology of the Blood-Brain Barrier

    XIV. Significance of the Blood-Brain Barrier

    XV. Mechanism of Homeostasis

    XVI. The Cerebrospinal Fluid and Brain Potentials

    XVII. Acid-Base Parameters

    XVIII. Some Special Features of the Blood-Brain Barrier System

    XIX. Modifications of the Barriers

    XX. Ontogeny of the Blood-Brain Barrier

    XXI. Special Regions of the Brain

    XXII. Peripheral Nerve



    10. The Extracellular Space in the Vertebrate Central Nervous System

    I. Space Determinations with Extracellular Markers

    II. Electrical Impedance of Central Nervous Tissue

    III. Chloride and Water Movements in Central Nervous Tissue

    IV. Electron Microscopy of Central Nervous Tissue

    V. Mechanisms Involved in the Electrolyte and Water Transport in Central Nervous Tissue


    Author Index

    Subject Index

Product details

  • No. of pages: 564
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323145886

About the Editor

Geoffrey Bourne

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