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Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN).
- The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements
- The major topics addressed are: development of the spinal cord; the gross anatomy of the spinal cord and its meninges; spinal nerves, nerve roots, and dorsal root ganglia; the vertebral column, vertebral joints, and vertebral muscles; blood supply of the spinal cord; cytoarchitecture and chemoarchitecture of the spinal gray matter; musculotopic anatomy of motoneuron groups; tracts connecting the brain and spinal cord; spinospinal pathways; sympathetic and parasympathetic elements in the spinal cord; neuronal groups and pathways that control micturition; the anatomy of spinal cord injury in experimental animals;
- The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse; Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. ; Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN)
- All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply.
Spinal cord researchers including anatomists, physiologists, neuropharmacologists, and clinicians
Chapter 1 The organization of the spinal cord Charles Watson and Gulgun Kayalioglu
The gross anatomy of the spinal cord Spinal cord segments Spinal nerves Spinal cord gray and white matter. Lateral cervical nucleus Lateral spinal nucleus Onuf’s nucleus Central canal Spinal cord meninges Vasculature of the spinal cord
Chapter 2 Development of the spinal cord Ken WS Ashwell
From neural plate to neural tube Neural crest development Alar and basal plates and their derivatives Segmentation of the developing spinal cord Motoneuron development and cell death Development of spinal cord afferents and dorsal horn interneurons Development of glia in the spinal cord Development of major ascending and descending tracts Myelination of spinal cord pathways Relative growth of the spinal cord and vertebral column
Chapter 3 The vertebral column and the spinal meninges Gulgun Kayalioglu
The vertebral column
General features of the vertebrae in mammals
Interspecific variation in vertebral number
The rodent vertebral column
Cervical vertebrae in humans
Thoracic vertebrae in humans
Lumbar vertebrae in humans.
The sacrum in humans
The coccyx in humans
Curvatures of the spine
Joints of the vertebrae
Joints between vertebral bodies
Joints between vertebral arches
The craniovertebral joints
The intrinsic muscles of the vertebral column The spinal meninges Intermediate leptomeningeal layer
Chapter 4 The spinal nerves Gulgun Kayalioglu
The anatomy of the dorsal and ventral roots and spinal nerves Dorsal root (spinal) ganglia Spinal nerves Dermatomes
Chapter 5 The spinal cord blood vessels Oscar U Scremin
Blood flow and spinal cord function Capillary networks Spinal cord blood flow imaging Arterial anatomy Venous anatomy Spinal cord lymphatic drainage Experimental spinal cord ischemia Blood flow in spinal cord trauma
Chapter 6 Cytoarchitecture of the spinal cord Claire Heise and Gulgun Kayalioglu
The laminae of Rexed Lamina 1 Lamina 2 Lamina 3 Lamina 4 The dorsal nucleus Lamina 5 Lamina 6 Lamina 7 Lamina 8 Lamina 9 Lamina 10
Chapter 7 Localization of motoneurons in the spinal cord Steve McHanwell and Charles Watson
Introduction – motoneuron types Cellular organization of neurons within the ventral and intermediate horns Experimental approaches to motoneuron localization Topography of motoneuron pools in the upper cervical spinal cord Topography of forelimb motoneuron pools in the cervical enlargement Topography of motoneuron pools in the thoracic and upper lumbar spinal cord Topography of hindlimb motoneuron pools in the lumbosacral spinal cord Muscles of the perineum Deep muscles of the back and tail
Chapter 8 Spinal autonomic preganglionic neurons: the visceral efferent system of the spinal cord Colin R Anderson, Janet R Keast, and Elspeth M McLachlan
Visceral efferent pathways Spatial distribution of preganglionic neurons Morphology of preganglionic neurons and arrangement of their dendrites Sympathetic preganglionic neurons Parasympathetic preganglionic neurons Chemistry of preganglionic neurons Chemistry of synaptic inputs to preganglionic neurons Regulation of pelvic organ function
Chapter 9 Central nervous system control of micturition Gert Holstege and Han Collewijn
Afferent fibers from bladder to sacral spinal cord Sensory endings in the bladder wall Sensory endings in the urethra Sacral cord Bladder C-fibers Bladder A-delta fibers Ascending projections Motor innervation of bladder and bladder sphincter Somatomotor innervation of the external bladder sphincter Sacral micturition reflexes Periaqueductal gray Pontine micturition center (PMC) Continence center or L-region Other brainstem-spinal pathways possibly involved in bladder and sphincter motoneuronal control Forebrain micturition control
Chapter 10 Projections from the spinal cord to the brain Gulgun Kayalioglu
Ascending spinal projections in the ventrolateral funiculus Other ascending projections in the ventrolateral funiculus Projections from the spinal cord to the cerebellum The dorsal spinocerebellar tract Dorsal column ascending pathways
Chapter 11 Projections from the brain to the spinal cord Charles Watson and Alan R Harvey
The corticospinal tract Hypothalamic and diencephalic projections to the spinal cord The rubrospinal tract The tectospinal tract Cerebellospinal projections The reticulospinal tracts Descending trigeminal and dorsal column nuclei projections The vestibulospinal tracts Raphespinal and coeruleospinal tracts The solitariospinal tract Projection from the retroambiguus nucleus to the spinal cord
Chapter 12 The propriospinal system Amanda C Conta and Dennis J Stelzner
The propriospinal system: definition and overall function Subgroups of propriospinal networks Propriospinal networks and neurotransmitters Locomotor propriospinal system across species Propriospinal projections and experimental spinal cord injury
Chapter 13 Spinal cord transmitter substances Claire Heise and Gulgun Kayalioglu
Cholinergic neurons Substance P Noradrenergic projections to the spinal cord Serotoninergic projections from the raphe Dopaminergic projections to the spinal cord
Chapter 14 Spinal cord injury: experimental animal models and relation to human therapy. Stuart I Hodgetts, Giles W Plant, and Alan R Harvey
General pathophysiology of SCI Types of spinal cord injury Immune and inflammatory responses following SCI Methods to induce spinal cord injury Assessing functional recovery in animal models of SCI Assessing human functional recovery Differences between animal models and humans and functional recovery after SCI Strategies to treat SCI Clinical trials
Chapter 15 Atlas of the rat spinal cord Charles Watson, George Paxinos. Gulgun Kayalioglu, and Claire Heise
Introduction Methods Cresyl violet staining and AChE histochemistry Immunohistochemical processing Mounting Photography and diagrams Nomenclature and abbreviations Basis of delineation of structures Naming of spinal cord segments Identification of regions and segments of the spinal cord in the rat and mouse List of structures Rat spinal cord figures and plates
Chapter 16 Atlas of the mouse spinal cord Charles Watson, George Paxinos. Gulgun Kayalioglu, and Claire Heise
Introduction Methods Mouse spinal cord sections provided by the Allen Institute for Brain Science Photography and diagrams Basis of delineation of structures List of structures Mouse spinal cord figures and plates
Chapter 17 Toward a spinal cord ontology Charles Watson and Amandeep Sidhu
What is an ontology? Regional subdivisions in the spinal cord A new regional classification based on development An ontological outline of spinal cord nomenclature Six levels in the spinal cord ontology Subdividing the limb enlargements into rostral and caudal groups Detailed similarities between the arrangement of motoneuron groups in the brachial and lumbar enlargements Similarities between the segments that immediately precede the upper and lower limb enlargements Does this spinal cord ontology have any practical application?
- No. of pages:
- © Academic Press 2008
- 12th November 2008
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Charles Watson is a neuroscientist and public health physician. His qualifications included a medical degree (MBBS) and two research doctorates (MD and DSc). He is Professor Emeritus at Curtin University, and holds adjunct professorial research positions at the University of New South Wales, the University of Queensland, and the University of Western Australia. He has published over 100 refereed journal articles and 40 book chapters, and has co-authored over 25 books on brain and spinal cord anatomy. The Paxinos Watson rat brain atlas has been cited over 80,000 times. His current research is focused on the comparative anatomy of the hippocampus and the claustrum. He was awarded the degree of Doctor of Science by the University of Sydney in 2012 and received the Distinguished Achievement Award of the Australasian Society for Neuroscience in 2018.
John Curtin Distinguished Professor of Health Science, Curtin University of Technology, Perth, Australia and Neuroscience Research Australia, NSW Sydney, Australia
Professor George Paxinos, AO (BA, MA, PhD, DSc) completed his BA at The University of California at Berkeley, his PhD at McGill University, and spent a postdoctoral year at Yale University. He is the author of almost 50 books on the structure of the brain of humans and experimental animals, including The Rat Brain in Stereotaxic Coordinates, now in its 7th Edition, which is ranked by Thomson ISI as one of the 50 most cited items in the Web of Science. Dr. Paxinos paved the way for future neuroscience research by being the first to produce a three-dimensional (stereotaxic) framework for placement of electrodes and injections in the brain of experimental animals, which is now used as an international standard. He was a member of the first International Consortium for Brain Mapping, a UCLA based consortium that received the top ranking and was funded by the NIMH led Human Brain Project. Dr. Paxinos has been honored with more than nine distinguished awards throughout his years of research, including: The Warner Brown Memorial Prize (University of California at Berkeley, 1968), The Walter Burfitt Prize (1992), The Award for Excellence in Publishing in Medical Science (Assoc Amer Publishers, 1999), The Ramaciotti Medal for Excellence in Biomedical Research (2001), The Alexander von Humbolt Foundation Prize (Germany 2004), and more.
Neuroscience Research Australia and The University of New South Wales, Sydney, Australia
Ege University, Izmir, Turkey
"This atlas provides an excellent, detailed map of the entire spinal cord of both rat and mouse. The photomicrographs are outstanding, the labelling is clear and the illustrations should serve as outstanding examples of what high quality staining and immunocytochemistry should look like. This information has not been available in any atlas of the CNS before, and will be an extremely useful resource for all neuroscientist interested in this part of the nervous system and a 'must-have' for spinal cord labs." --Jacqueline C. Bresnahan, Professor, Department of Neurological Surgery, Brain and Spinal Injury Center, University of California at San Francisco, USA
"The Spinal Cord is an authoritative and detailed account of the development, organization and function of the spinal cord. Written by a series of experts, the book contains enlightening chapters that cover the anatomy and the architecture of the spinal cord in a clear and logical fashion. Attention to special topics, such as spinal cord injury and micturition, is unprecedented and unusually informative. The comprehensive atlas, along with the diagrams and list of references, will be of considerable use to the students of the nervous system, as well as the most senior of investigators. It is an excellent volume!" --Moses V. Chao, Professor of Cell Biology, Physiology and Neuroscience and Psychiatry, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, USA
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