Description

Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related pept

Key Features

The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements. The major topics addressed are: development of the spinal cord the gross anatomy of the spinal cord and its meninges spinal nerves, nerve roots, and dorsal root ganglia the vertebral column, vertebral joints, and vertebral muscles blood supply of the spinal cord cytoarchitecture and chemoarchitecture of the spinal gray matter musculotopic anatomy of motoneuron groups tracts connecting the brain and spinal cord spinospinal pathways sympathetic and parasympathetic elements in the spinal cord neuronal groups and pathways that control micturition the anatomy of spinal cord injury in experimental animals The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse. Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN). All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply.

Readership

Spinal cord researchers including anatomists, physiologists, neuropharmacologists, and clinicians.

Table of Contents

Chapter 1 The organization of the spinal cord Charles Watson and Gulgun Kayalioglu The gross anatomy of the spinal cord Spinal cord segments Spinal nerves Spinal cord gray and white matter. Lateral cervical nucleus Lateral spinal nucleus Onuf’s nucleus Central canal Spinal cord meninges Vasculature of the spinal cord Chapter 2 Development of the spinal cord Ken WS Ashwell From neural plate to neural tube Neural crest development Alar and basal plates and their derivatives Segmentation of the developing spinal cord Motoneuron development and cell death Development of spinal cord afferents and dorsal horn interneurons Development of glia in the spinal cord Development of major ascending and descending tracts Myelination of spinal cord pathways Relative growth of the spinal cord and vertebral column Chapter 3 The vertebral column and the spinal meninges Gulgun Kayalioglu The vertebral column General features of the vertebrae in mammals Interspecific variation in vertebral number The rodent vertebral column Cervical vertebrae in humans Thoracic vertebrae in humans Lumbar vertebrae in humans. The sacrum in humans The coccyx in humans Curvatures of the spine Joints of the vertebrae Joints between vertebral bodies Joints between vertebral arches The craniovertebral joints Lumbosacral joints Sacrococcygeal joint Int

Details

No. of pages:
408
Language:
English
Copyright:
© 2008
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080921389
Print ISBN:
9780123742476

About the editors

George Paxinos

Professor George Paxinos, AO (BA, MA, PhD, DSc) completed his BA at The University of California at Berkeley, his PhD at McGill University, and spent a postdoctoral year at Yale University. He is the author of almost 50 books on the structure of the brain of humans and experimental animals, including The Rat Brain in Stereotaxic Coordinates, now in its 7th Edition, which is ranked by Thomson ISI as one of the 50 most cited items in the Web of Science. Dr. Paxinos paved the way for future neuroscience research by being the first to produce a three-dimensional (stereotaxic) framework for placement of electrodes and injections in the brain of experimental animals, which is now used as an international standard. He was a member of the first International Consortium for Brain Mapping, a UCLA based consortium that received the top ranking and was funded by the NIMH led Human Brain Project. Dr. Paxinos has been honored with more than nine distinguished awards throughout his years of research, including: The Warner Brown Memorial Prize (University of California at Berkeley, 1968), The Walter Burfitt Prize (1992), The Award for Excellence in Publishing in Medical Science (Assoc Amer Publishers, 1999), The Ramaciotti Medal for Excellence in Biomedical Research (2001), The Alexander von Humbolt Foundation Prize (Germany 2004), and more.

Reviews

"This atlas provides an excellent, detailed map of the entire spinal cord of both rat and mouse. The photomicrographs are outstanding, the labelling is clear and the illustrations should serve as outstanding examples of what high quality staining and immunocytochemistry should look like. This information has not been available in any atlas of the CNS before, and will be an extremely useful resource for all neuroscientist interested in this part of the nervous system and a 'must-have' for spinal cord labs." Jacqueline C. Bresnahan, Professor, Department of Neurological Surgery, Brain and Spinal Injury Center, University of California at San Francisco, USA “The Spinal Cord is an authoritative and detailed account of the development, organization and function of the spinal cord. Written by a series of experts, the book contains enlightening chapters that cover the anatomy and the architecture of the spinal cord in a clear and logical fashion. Attention to special topics, such as spinal cord injury and micturition, is unprecedented and unusually informative. The comprehensive atlas, along with the diagrams and list of references, will be of considerable use to the students of the nervous system, as well as the most senior of investigators. It is an excellent volume!” Moses V. Chao, Professor of Cell Biology, Physiology and Neuroscience and Psychiatry, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, USA