Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related pept
The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements. The major topics addressed are:
development of the spinal cord
the gross anatomy of the spinal cord and its meninges
spinal nerves, nerve roots, and dorsal root ganglia
the vertebral column, vertebral joints, and vertebral muscles
blood supply of the spinal cord
cytoarchitecture and chemoarchitecture of the spinal gray matter
musculotopic anatomy of motoneuron groups
tracts connecting the brain and spinal cord
sympathetic and parasympathetic elements in the spinal cord
neuronal groups and pathways that control micturition
the anatomy of spinal cord injury in experimental animals
The atlas of the rat and mouse spinal cord has the following features:
Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse.
Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level.
Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN).
All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply.
Spinal cord researchers including anatomists, physiologists, neuropharmacologists, and clinicians.
Chapter 1 The organization of the spinal cord Charles Watson and Gulgun Kayalioglu
The gross anatomy of the spinal cord Spinal cord segments Spinal nerves Spinal cord gray and white matter. Lateral cervical nucleus Lateral spinal nucleus Onuf’s nucleus Central canal Spinal cord meninges Vasculature of the spinal cord
Chapter 2 Development of the spinal cord Ken WS Ashwell
From neural plate to neural tube Neural crest development Alar and basal plates and their derivatives Segmentation of the developing spinal cord Motoneuron development and cell death Development of spinal cord afferents and dorsal horn interneurons Development of glia in the spinal cord Development of major ascending and descending tracts Myelination of spinal cord pathways Relative growth of the spinal cord and vertebral column
Chapter 3 The vertebral column and the spinal meninges Gulgun Kayalioglu
The vertebral column General features of the vertebrae in mammals Interspecific variation in vertebral number The rodent vertebral column Cervical vertebrae in humans Thoracic vertebrae in humans Lumbar vertebrae in humans. The sacrum in humans The coccyx in humans Curvatures of the spine Joints of the vertebrae Joints between vertebral bodies Joints between vertebral arches The craniovertebral joints Lumbosacral joints Sacrococcygeal joint Int
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- © Academic Press 2008
- 12th November 2008
- Academic Press
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Charles Watson is a specialist in the area of brain and spinal cord mapping. He graduated in medicine from the University of Sydney in 1967 and was awarded a research doctorate (MD) by the University of New South Wales in 1974. He lectured in anatomy at the UNSW from 1970 to 1982, when he took up a career in public health in the Health Department of Western Australia, being appointed Chief Health Officer for WA in 1993. He returned to university life in 1994, holding the position of Dean of Health Sciences at the University of Wollongong and Curtin University until 2006. Since then he has held research positions at Curtin and at Neuroscience Research Australia. Since 2006 he has published 11 books and over 40 journal articles. Watson was made a member of the Order of Australia (AM) in 2004. He earned a DSc (by thesis) from the University of Sydney in 2012. In his spare time he swims in the ocean, and he is an enthusiastic but mediocre player of the baritone saxophone. His musical favourites are Frank Zappa, Brian Eno, and Beethoven.
John Curtin Distinguished Professor of Health Science, Curtin University of Technology, Perth, Australia
Professor George Paxinos, AO (BA, MA, PhD, DSc) completed his BA at The University of California at Berkeley, his PhD at McGill University, and spent a postdoctoral year at Yale University. He is the author of almost 50 books on the structure of the brain of humans and experimental animals, including The Rat Brain in Stereotaxic Coordinates, now in its 7th Edition, which is ranked by Thomson ISI as one of the 50 most cited items in the Web of Science. Dr. Paxinos paved the way for future neuroscience research by being the first to produce a three-dimensional (stereotaxic) framework for placement of electrodes and injections in the brain of experimental animals, which is now used as an international standard. He was a member of the first International Consortium for Brain Mapping, a UCLA based consortium that received the top ranking and was funded by the NIMH led Human Brain Project. Dr. Paxinos has been honored with more than nine distinguished awards throughout his years of research, including: The Warner Brown Memorial Prize (University of California at Berkeley, 1968), The Walter Burfitt Prize (1992), The Award for Excellence in Publishing in Medical Science (Assoc Amer Publishers, 1999), The Ramaciotti Medal for Excellence in Biomedical Research (2001), The Alexander von Humbolt Foundation Prize (Germany 2004), and more.
Neuroscience Research Australia and The University of New South Wales, Sydney, Australia
Ege University, Izmir, Turkey
"This atlas provides an excellent, detailed map of the entire spinal cord of both rat and mouse. The photomicrographs are outstanding, the labelling is clear and the illustrations should serve as outstanding examples of what high quality staining and immunocytochemistry should look like. This information has not been available in any atlas of the CNS before, and will be an extremely useful resource for all neuroscientist interested in this part of the nervous system and a 'must-have' for spinal cord labs." Jacqueline C. Bresnahan, Professor, Department of Neurological Surgery, Brain and Spinal Injury Center, University of California at San Francisco, USA “The Spinal Cord is an authoritative and detailed account of the development, organization and function of the spinal cord. Written by a series of experts, the book contains enlightening chapters that cover the anatomy and the architecture of the spinal cord in a clear and logical fashion. Attention to special topics, such as spinal cord injury and micturition, is unprecedented and unusually informative. The comprehensive atlas, along with the diagrams and list of references, will be of considerable use to the students of the nervous system, as well as the most senior of investigators. It is an excellent volume!” Moses V. Chao, Professor of Cell Biology, Physiology and Neuroscience and Psychiatry, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, NYU School of Medicine, New York, USA