The Somatotrophic Axis in Brain Function - 1st Edition - ISBN: 9780120884841, 9780080498164

The Somatotrophic Axis in Brain Function

1st Edition

Editors: Fred Nyberg
Hardcover ISBN: 9780120884841
eBook ISBN: 9780080498164
Imprint: Academic Press
Published Date: 22nd November 2005
Page Count: 384
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Description

  • Preface
  • Pioneers in the growth hormone field
  • Section 1: Biosynthesis of Growth Hormone and Insulin-like Growth Factor-I and Regulation of Their Secretion
    • Introduction
    • Chapter 1: Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE
      • III INSULIN-LIKE GROWTH FACTOR-I
      • IV FUTURE PERSPECTIVES
    • Chapter 2: Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE SECRETAGOGUE AND ITS RECEPTOR
      • III PURIFICATION AND IDENTIFICATION OF GHRELIN
      • IV DISTRIBUTION OF GHRELIN
      • V PHYSIOLOGICAL FUNCTIONS OF GHRELIN
      • VI GHRELIN KNOCKOUT MOUSE
      • VII GHRELIN RECEPTOR KNOCKOUT MOUSE
      • VIII REGULATION OF GHRELIN SECRETION
      • IX EPILOGUE
      • Acknowledgments
  • Section 2: Growth Hormone and Insulin-like Growth Factor-I and their Function at the Receptor Level
    • Chapter 3: Mechanisms of Signal Transduction Utilized by Growth Hormone
      • Publisher Summary
      • I INTRODUCTION
      • II THE GROWTH HORMONE RECEPTOR
      • III SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY GROWTH HORMONE
      • IV CONCLUSION
    • Chapter 4: Insulin-like Growth Factor-I and Its Binding Proteins: Regulation of Secretion and Mechanism of Action at the Receptor Level
      • Publisher Summary
      • 1 INTRODUCTION AND OVERVIEW
      • II OVERVIEW OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS
      • II SUMMARY AND FUTURE PERSPECTIVE
      • Acknowledgments
  • Section 3: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System
    • Chapter 5: Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) IN THE CEREBROSPINAL FLUID (CSF) COMPARTMENT
      • III RELATIONS BETWEEN CSF DETECTABLE LEVELS OF GROWTH HORMONE AND IGF-I TO VARIOUS PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONDITIONS
      • IV FUTURE PERSPECTIVES
      • Acknowledgment
    • Chapter 6: Growth Hormone, Insulin, and Insulin-like Growth Factor-I: Do They Interact at the Blood-Brain Barrier?
      • Publisher Summary
      • I WHY THERE IS AN ISSUE ABOUT WHETHER GROWTH HORMONE (GH) CROSSES THE BLOOD–BRAIN BARRIER (BBB)
      • II CURRENT KNOWLEDGE ABOUT THE TRANSPORT SYSTEMS FOR INSULIN AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AT THE BBB
      • III ABSENCE OF A SATURABLE TRANSPORT SYSTEM FOR GH AT THE BBB
      • IV LACK OF DIRECT INTERACTION OF GH AND INSULIN AT THE BBB, BUT IGF-I MAY BE AN INDIRECT MEDIATOR
      • V CONCLUSIONS
      • Acknowledgment
    • Chapter 7: Growth Hormone and Insulin-like Growth Factors in the Central Nervous System: Localization in Mammalian Species
      • Publisher Summary
      • I EXPRESSION OF THE GROWTH HORMONE SYSTEM IN THE MAMMALIAN BRAIN
      • II EXPRESSION OF THE IGF SYSTEM IN THE BRAIN
    • Chapter 8: Purification of Growth Hormone Receptors from Human Brain Tissues
      • Publisher Summary
      • I INTRODUCTION
      • II METHODS FOR PURIFICATION
      • III CHARACTERISTICS OF HIGHLY AND PARTLY PURIFIED GROWTH HORMONE (GH) RECEPTORS
      • IV CONCLUSION
      • Acknowledgment
    • Chapter 9: Growth Hormone Receptor Message in the Rat and Human Central Nervous System: Structure and Function
      • Publisher Summary
      • I INTRODUCTION
      • II CLONING OF THE GROWTH HORMONE RECEPTOR (GHR)
      • III GROWTH HORMONE-BINDING PROTEIN
      • IV GHR mRNA IN THE CENTRAL NERVOUS SYSTEM (CNS)
      • V REGULATION OF GHR GENE EXPRESSION
      • Acknowledgment
  • Section 4: Central Nervous System Action of Growth Hormone: Basic Studies Using Animal Models
    • Chapter 10: Interaction of Growth Hormone and Prolactin in Brain Circuits
      • Publisher Summary
      • I INTRODUCTION
      • II COMMON FEATURES OF THE SOMATOTROPHIC AND LACTOTROPHIC SYSTEMS IN THE CENTRAL NERVOUS SYSTEM
      • III DIFFERENTIAL ACTIONS OF GROWTH HORMONE AND PROLACTIN IN THE BRAIN
      • IV POTENTIAL INTERACTION OF THE TWO HORMONES IN BRAIN FUNCTION
      • V CONCLUSION
    • Chapter 11: Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain
      • Publisher Summary
      • I INTRODUCTION
      • II NEUROPROTECTIVE ACTIONS OF THE SOMATOTROPHIC AXIS
      • III MODELS AND TECHNIQUES
      • IV ADULT CELL GENESIS BY INSULIN-LIKE FACTOR-I AND GROWTH HORMONE
      • V PHYSIOLOGICAL AND FUNCTIONAL CORRELATES TO ADULT CELL GENESIS
    • Chapter 12: Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions
      • Publisher Summary
      • I GAP JUNCTIONS AND CONNEXINS IN THE CENTRAL NERVOUS SYSTEM (CNS)
      • II ASTROCYTES IN THE CNS
      • III GROWTH HORMONE (GH) AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND ASTROCYTES AND CONNEXIN43 – GAP JUNCTIONS
      • IV METHODOLOGICAL ASPECTS
      • V SIGNIFICANCE OF REGULATION OF CONNEXIN43 AND GAP JUNCTIONAL COUPLING
      • VI REGULATION OF CONNEXIN43 BY GH AND IGF-I IN THE CONTEXT OF OTHER EFFECTS
      • VII GAP JUNCTIONAL PLASTICITY AND CORTICAL FUNCTIONS
    • Chapter 13: Rodent Models for the Study of the Role of Growth Hormone–Insulin-like Growth Factor-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction
      • Publisher Summary
      • I INTRODUCTION
      • II LONGEVITY MODELS FOR THE GROWTH HORMONE–INSULIN-LIKE GROWTH FACTOR-I/INSULIN AXIS
      • III THE GLUCOSE–INSULIN SYSTEM
      • IV STRESS RESPONSE
      • V CONCLUSION
    • Chapter 14: Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function
      • Publisher Summary
      • I INTRODUCTION
      • II THE GROWTH HORMONE/INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AXIS
      • III ACTIONS OF GROWTH HORMONE AND IGF-I IN THE MAMMALIAN BRAIN
      • IV GROWTH HORMONE/IGF-I AXIS AND BRAIN AGING
      • V SUMMARY
    • Chapter 15: Insulin-like Growth Factor-I and Neuroprotection
      • Publisher Summary
      • I INTRODUCTION
      • II NEUROPROTECTIVE SIGNALING
      • III INSULIN-LIKE GROWTH FACTOR-I (IGF-I) REGULATES NEW BRAIN CELL POPULATIONS
      • IV IGF-I MAINTAINS BRAIN CELL FUNCTION
      • V MECHANISMS OF NEUROPROTECTION BY IGF-I
      • VI LOSS OF IGF-I FUNCTION CONTRIBUTES TO BRAIN AGING AND DISEASE
      • VII PERSPECTIVES
      • Acknowledgment
  • Section 5: Immediate and Long-Term Benefits on the Central Nervous System and Growth Hormone Replacement Therapy
    • Chapter 16: Quality of Life in Adult Growth Hormone Deficiency
      • Publisher Summary
      • I INTRODUCTION
      • II WHY IS QUALITY OF LIFE (QoL) IMPORTANT?
      • III WHAT DO WE MEAN BY “QUALITY OF LIFE?”
      • IV MEASUREMENT OF QUALITY OF LIFE
      • V EFFECT OF UNTREATED GROWTH HORMONE (GH) DEFICIENCY (GHD) ON QUALITY OF LIFE
      • VI IS GH CAUSATIVE IN THE IMPAIRED QoL OF HYPOPITUITARY ADULTS?
      • VII QoL FOLLOWING DISCONTINUATION OF CHILDHOOD GH THERAPY
      • VIII NATURAL HISTORY OF QoL IN ADULTS WITH UNTREATED GHD
      • IX EFFECTS OF GH REPLACEMENT ON QoL IN GHD HYPOPITUITARY ADULTS
      • X SPECIFIC PATIENT GROUPS
      • XI EFFECT OF LONG-TERM GH REPLACEMENT ON QoL
      • XII PREDICTORS OF IMPROVEMENTS IN QoL WITH GH REPLACEMENT
      • XIII POTENTIAL BIASES IN OPEN STUDIES OF QoL
      • XIV SUMMARY
    • Chapter 17: The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology
      • Publisher Summary
      • I INTRODUCTION
      • II SLEEP
      • III MOOD AND PSYCHIATRIC SYMPTOMS
    • Chapter 18: Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality
      • Publisher Summary
      • I INTRODUCTION
      • II QUALITY OF LIFE (QoL) MEASUREMENTS
      • III QoL IN GROWTH HORMONE (GH)-DEFICIENT ADULTS
      • IV EFFECTS OF GH DEFICIENCY AND GH THERAPY ON QoL IN SPECIFIC CONDITIONS
      • V THERAPEUTIC MECHANISMS OF GH REPLACEMENT
      • VI COST–BENEFIT CONSIDERATIONS
      • VII CONCLUSION
    • Chapter 19: Psychological Importance to the Child of Growth Hormone Replacement
      • Publisher Summary
      • I INTRODUCTION
      • II MODES OF ACTION OF GROWTH HORMONE (GH)
      • III LOCATION OF ACTION OF GH
      • IV GH SECRETION VERSUS SENSITIVITY
      • V TYPICAL COGNITIVE DEVELOPMENT AND CRITICAL WINDOWS OF DEVELOPMENT
      • VI EFFECT OF GH ON COGNITIVE AND ACADEMIC PERFORMANCE
      • VII EFFECT OF GH ON PSYCHOLOGICAL WELL-BEING
      • VIII METHODOLOGICAL DIFFICULTIES IN MEASUREMENT
      • IX FUTURE DIRECTIONS
    • Chapter 20: Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations
      • Publisher Summary
      • I BRAIN EFFECTS DURING GROWTH HORMONE HYPERSECRETION
      • II TREATMENT OF GROWTH HORMONE-PRODUCING TUMORS
    • Chapter 21: Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia
      • Publisher Summary
      • I INTRODUCTION
      • II AGE-RELATED CHANGES IN ACTIVITY OF THE GROWTH HORMONE (GH)/INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AXIS: FOCUS ON NORMAL AGING
      • III GH/IGF-I AXIS IN DEMENTIA: FOCUS ON ALZHEIMER’S DISEASE
      • IV GH/IGF-I AXIS IN DOWN SYNDROME: A CLINICAL MODEL OF ANTICIPATED AGING OF THE GH/IGF/I AXIS
      • V CONCLUSIONS
    • Chapter 22: Cognitive Status of Adult Growth Hormone (GH)-Deficient Patients and GH-Induced Neuropsychological Changes
      • Publisher Summary
      • I INTRODUCTION
      • II DETERMINATION OF THE ROLE OF GROWTH HORMONE (GH) IN COGNITIVE FUNCTIONS
      • III COGNITIVE EFFECTS OF GH-INDUCED HORMONAL CHANGES
      • IV COGNITIVE STATUS IN RELATION TO GH DEFICIENCY (GHD) AND GH TREATMENT
      • V META-ANALYSIS GH AND NEUROPSYCHOLOGICAL FUNCTIONS
      • VI COGNITIVE EFFECTS OF DISCONTINUED GH TREATMENT
      • VII GH DOSAGES AND COGNITIVE STATUS IN GH-DEFICIENT ADULTS
      • VIII GH AND INSULIN-LIKE GROWTH FACTOR I REPLACEMENT IN SYNDROMES OTHER THAN GHD
      • IX GH-INDUCED COGNITIVE CHANGES IN HEALTHY ELDERLY SUBJECTS
      • X CONCLUSION
    • Chapter 23: Growth Hormone and Insulin-like Growth Factor-I in Alzheimer’s Disease
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND COGNITIVE DECLINE IN THE ELDERLY
      • III INTERACTIONS BETWEEN IGF-I SYSTEM AND ALZHEIMER’S DISEASE
      • IV GROWTH HORMONE IN ALZHEIMER’S DISEASE
      • V GROWTH HORMONE RESPONSE IN ALZHEIMER’S DISEASE
      • VI SOMATOSTATIN IN CEREBROSPINAL FLUID IN ALZHEIMER’S DISEASE
      • VII RELATIONSHIP BETWEEN ALZHEIMER’S DISEASE TREATMENT AND IGF-I SYSTEM AND GROWTH HORMONE RESPONSE TO STIMULI
      • VIII POSSIBLE USEFULNESS OF GROWTH HORMONE/IGF-I AXIS IN ALZHEIMER’S DISEASE TREATMENT
  • Section 6: Growth Hormone Replacement and Related Therapies in Central Nervous System Disorders: A Future Perspective
    • Chapter 24: Growth Hormone Antagonists: A Pharmacological Tool in Present and Future Therapies
      • Publisher Summary
      • 1 INTRODUCTION
      • II THE DISCOVERY OF GROWTH HORMONE ANTAGONISTS
      • III DEVELOPMENT OF PEGVISOMANT
      • IV PRECLINICAL TRIALS
      • V CLINICAL TRIALS
      • VI OTHER USES OF PEGVISOMANT
      • VII CONCLUSION
      • Acknowledgments
    • Chapter 25: Growth Hormone Replacement Therapy and Life Quality: Future Perspectives
      • Publisher Summary
      • I CASE STUDY: NEUROPROTECTIVE EFFECT OF GROWTH HORMONE IN SPINAL CORD INJURY
      • II GROWTH HORMONE REPLACEMENT AND LIFE QUALITY IN THE FRAIL ELDERLY
      • III GROWTH HORMONE REPLACEMENT AND QUALITY OF LIFE IN ADULTS WITH GROWTH HORMONE DEFICIENCY
  • Index

Key Features

Contents are well balanced and cover a variety of relevant topics from basic to clinical research

International selection of authors, with a good representation of the research on growth hormones

A timely publication which will be useful to scientists in both basic and clinical research

Readership

Basic scientists and clinical researchers in neurology, endocrinology, and neuroscience.

Table of Contents

  • Preface
  • Pioneers in the growth hormone field
  • Section 1: Biosynthesis of Growth Hormone and Insulin-like Growth Factor-I and Regulation of Their Secretion
    • Introduction
    • Chapter 1: Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE
      • III INSULIN-LIKE GROWTH FACTOR-I
      • IV FUTURE PERSPECTIVES
    • Chapter 2: Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE SECRETAGOGUE AND ITS RECEPTOR
      • III PURIFICATION AND IDENTIFICATION OF GHRELIN
      • IV DISTRIBUTION OF GHRELIN
      • V PHYSIOLOGICAL FUNCTIONS OF GHRELIN
      • VI GHRELIN KNOCKOUT MOUSE
      • VII GHRELIN RECEPTOR KNOCKOUT MOUSE
      • VIII REGULATION OF GHRELIN SECRETION
      • IX EPILOGUE
      • Acknowledgments
  • Section 2: Growth Hormone and Insulin-like Growth Factor-I and their Function at the Receptor Level
    • Chapter 3: Mechanisms of Signal Transduction Utilized by Growth Hormone
      • Publisher Summary
      • I INTRODUCTION
      • II THE GROWTH HORMONE RECEPTOR
      • III SIGNAL TRANSDUCTION PATHWAYS ACTIVATED BY GROWTH HORMONE
      • IV CONCLUSION
    • Chapter 4: Insulin-like Growth Factor-I and Its Binding Proteins: Regulation of Secretion and Mechanism of Action at the Receptor Level
      • Publisher Summary
      • 1 INTRODUCTION AND OVERVIEW
      • II OVERVIEW OF INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS
      • II SUMMARY AND FUTURE PERSPECTIVE
      • Acknowledgments
  • Section 3: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System
    • Chapter 5: Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) IN THE CEREBROSPINAL FLUID (CSF) COMPARTMENT
      • III RELATIONS BETWEEN CSF DETECTABLE LEVELS OF GROWTH HORMONE AND IGF-I TO VARIOUS PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONDITIONS
      • IV FUTURE PERSPECTIVES
      • Acknowledgment
    • Chapter 6: Growth Hormone, Insulin, and Insulin-like Growth Factor-I: Do They Interact at the Blood-Brain Barrier?
      • Publisher Summary
      • I WHY THERE IS AN ISSUE ABOUT WHETHER GROWTH HORMONE (GH) CROSSES THE BLOOD–BRAIN BARRIER (BBB)
      • II CURRENT KNOWLEDGE ABOUT THE TRANSPORT SYSTEMS FOR INSULIN AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AT THE BBB
      • III ABSENCE OF A SATURABLE TRANSPORT SYSTEM FOR GH AT THE BBB
      • IV LACK OF DIRECT INTERACTION OF GH AND INSULIN AT THE BBB, BUT IGF-I MAY BE AN INDIRECT MEDIATOR
      • V CONCLUSIONS
      • Acknowledgment
    • Chapter 7: Growth Hormone and Insulin-like Growth Factors in the Central Nervous System: Localization in Mammalian Species
      • Publisher Summary
      • I EXPRESSION OF THE GROWTH HORMONE SYSTEM IN THE MAMMALIAN BRAIN
      • II EXPRESSION OF THE IGF SYSTEM IN THE BRAIN
    • Chapter 8: Purification of Growth Hormone Receptors from Human Brain Tissues
      • Publisher Summary
      • I INTRODUCTION
      • II METHODS FOR PURIFICATION
      • III CHARACTERISTICS OF HIGHLY AND PARTLY PURIFIED GROWTH HORMONE (GH) RECEPTORS
      • IV CONCLUSION
      • Acknowledgment
    • Chapter 9: Growth Hormone Receptor Message in the Rat and Human Central Nervous System: Structure and Function
      • Publisher Summary
      • I INTRODUCTION
      • II CLONING OF THE GROWTH HORMONE RECEPTOR (GHR)
      • III GROWTH HORMONE-BINDING PROTEIN
      • IV GHR mRNA IN THE CENTRAL NERVOUS SYSTEM (CNS)
      • V REGULATION OF GHR GENE EXPRESSION
      • Acknowledgment
  • Section 4: Central Nervous System Action of Growth Hormone: Basic Studies Using Animal Models
    • Chapter 10: Interaction of Growth Hormone and Prolactin in Brain Circuits
      • Publisher Summary
      • I INTRODUCTION
      • II COMMON FEATURES OF THE SOMATOTROPHIC AND LACTOTROPHIC SYSTEMS IN THE CENTRAL NERVOUS SYSTEM
      • III DIFFERENTIAL ACTIONS OF GROWTH HORMONE AND PROLACTIN IN THE BRAIN
      • IV POTENTIAL INTERACTION OF THE TWO HORMONES IN BRAIN FUNCTION
      • V CONCLUSION
    • Chapter 11: Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain
      • Publisher Summary
      • I INTRODUCTION
      • II NEUROPROTECTIVE ACTIONS OF THE SOMATOTROPHIC AXIS
      • III MODELS AND TECHNIQUES
      • IV ADULT CELL GENESIS BY INSULIN-LIKE FACTOR-I AND GROWTH HORMONE
      • V PHYSIOLOGICAL AND FUNCTIONAL CORRELATES TO ADULT CELL GENESIS
    • Chapter 12: Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions
      • Publisher Summary
      • I GAP JUNCTIONS AND CONNEXINS IN THE CENTRAL NERVOUS SYSTEM (CNS)
      • II ASTROCYTES IN THE CNS
      • III GROWTH HORMONE (GH) AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND ASTROCYTES AND CONNEXIN43 – GAP JUNCTIONS
      • IV METHODOLOGICAL ASPECTS
      • V SIGNIFICANCE OF REGULATION OF CONNEXIN43 AND GAP JUNCTIONAL COUPLING
      • VI REGULATION OF CONNEXIN43 BY GH AND IGF-I IN THE CONTEXT OF OTHER EFFECTS
      • VII GAP JUNCTIONAL PLASTICITY AND CORTICAL FUNCTIONS
    • Chapter 13: Rodent Models for the Study of the Role of Growth Hormone–Insulin-like Growth Factor-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction
      • Publisher Summary
      • I INTRODUCTION
      • II LONGEVITY MODELS FOR THE GROWTH HORMONE–INSULIN-LIKE GROWTH FACTOR-I/INSULIN AXIS
      • III THE GLUCOSE–INSULIN SYSTEM
      • IV STRESS RESPONSE
      • V CONCLUSION
    • Chapter 14: Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function
      • Publisher Summary
      • I INTRODUCTION
      • II THE GROWTH HORMONE/INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AXIS
      • III ACTIONS OF GROWTH HORMONE AND IGF-I IN THE MAMMALIAN BRAIN
      • IV GROWTH HORMONE/IGF-I AXIS AND BRAIN AGING
      • V SUMMARY
    • Chapter 15: Insulin-like Growth Factor-I and Neuroprotection
      • Publisher Summary
      • I INTRODUCTION
      • II NEUROPROTECTIVE SIGNALING
      • III INSULIN-LIKE GROWTH FACTOR-I (IGF-I) REGULATES NEW BRAIN CELL POPULATIONS
      • IV IGF-I MAINTAINS BRAIN CELL FUNCTION
      • V MECHANISMS OF NEUROPROTECTION BY IGF-I
      • VI LOSS OF IGF-I FUNCTION CONTRIBUTES TO BRAIN AGING AND DISEASE
      • VII PERSPECTIVES
      • Acknowledgment
  • Section 5: Immediate and Long-Term Benefits on the Central Nervous System and Growth Hormone Replacement Therapy
    • Chapter 16: Quality of Life in Adult Growth Hormone Deficiency
      • Publisher Summary
      • I INTRODUCTION
      • II WHY IS QUALITY OF LIFE (QoL) IMPORTANT?
      • III WHAT DO WE MEAN BY “QUALITY OF LIFE?”
      • IV MEASUREMENT OF QUALITY OF LIFE
      • V EFFECT OF UNTREATED GROWTH HORMONE (GH) DEFICIENCY (GHD) ON QUALITY OF LIFE
      • VI IS GH CAUSATIVE IN THE IMPAIRED QoL OF HYPOPITUITARY ADULTS?
      • VII QoL FOLLOWING DISCONTINUATION OF CHILDHOOD GH THERAPY
      • VIII NATURAL HISTORY OF QoL IN ADULTS WITH UNTREATED GHD
      • IX EFFECTS OF GH REPLACEMENT ON QoL IN GHD HYPOPITUITARY ADULTS
      • X SPECIFIC PATIENT GROUPS
      • XI EFFECT OF LONG-TERM GH REPLACEMENT ON QoL
      • XII PREDICTORS OF IMPROVEMENTS IN QoL WITH GH REPLACEMENT
      • XIII POTENTIAL BIASES IN OPEN STUDIES OF QoL
      • XIV SUMMARY
    • Chapter 17: The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology
      • Publisher Summary
      • I INTRODUCTION
      • II SLEEP
      • III MOOD AND PSYCHIATRIC SYMPTOMS
    • Chapter 18: Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality
      • Publisher Summary
      • I INTRODUCTION
      • II QUALITY OF LIFE (QoL) MEASUREMENTS
      • III QoL IN GROWTH HORMONE (GH)-DEFICIENT ADULTS
      • IV EFFECTS OF GH DEFICIENCY AND GH THERAPY ON QoL IN SPECIFIC CONDITIONS
      • V THERAPEUTIC MECHANISMS OF GH REPLACEMENT
      • VI COST–BENEFIT CONSIDERATIONS
      • VII CONCLUSION
    • Chapter 19: Psychological Importance to the Child of Growth Hormone Replacement
      • Publisher Summary
      • I INTRODUCTION
      • II MODES OF ACTION OF GROWTH HORMONE (GH)
      • III LOCATION OF ACTION OF GH
      • IV GH SECRETION VERSUS SENSITIVITY
      • V TYPICAL COGNITIVE DEVELOPMENT AND CRITICAL WINDOWS OF DEVELOPMENT
      • VI EFFECT OF GH ON COGNITIVE AND ACADEMIC PERFORMANCE
      • VII EFFECT OF GH ON PSYCHOLOGICAL WELL-BEING
      • VIII METHODOLOGICAL DIFFICULTIES IN MEASUREMENT
      • IX FUTURE DIRECTIONS
    • Chapter 20: Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations
      • Publisher Summary
      • I BRAIN EFFECTS DURING GROWTH HORMONE HYPERSECRETION
      • II TREATMENT OF GROWTH HORMONE-PRODUCING TUMORS
    • Chapter 21: Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia
      • Publisher Summary
      • I INTRODUCTION
      • II AGE-RELATED CHANGES IN ACTIVITY OF THE GROWTH HORMONE (GH)/INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AXIS: FOCUS ON NORMAL AGING
      • III GH/IGF-I AXIS IN DEMENTIA: FOCUS ON ALZHEIMER’S DISEASE
      • IV GH/IGF-I AXIS IN DOWN SYNDROME: A CLINICAL MODEL OF ANTICIPATED AGING OF THE GH/IGF/I AXIS
      • V CONCLUSIONS
    • Chapter 22: Cognitive Status of Adult Growth Hormone (GH)-Deficient Patients and GH-Induced Neuropsychological Changes
      • Publisher Summary
      • I INTRODUCTION
      • II DETERMINATION OF THE ROLE OF GROWTH HORMONE (GH) IN COGNITIVE FUNCTIONS
      • III COGNITIVE EFFECTS OF GH-INDUCED HORMONAL CHANGES
      • IV COGNITIVE STATUS IN RELATION TO GH DEFICIENCY (GHD) AND GH TREATMENT
      • V META-ANALYSIS GH AND NEUROPSYCHOLOGICAL FUNCTIONS
      • VI COGNITIVE EFFECTS OF DISCONTINUED GH TREATMENT
      • VII GH DOSAGES AND COGNITIVE STATUS IN GH-DEFICIENT ADULTS
      • VIII GH AND INSULIN-LIKE GROWTH FACTOR I REPLACEMENT IN SYNDROMES OTHER THAN GHD
      • IX GH-INDUCED COGNITIVE CHANGES IN HEALTHY ELDERLY SUBJECTS
      • X CONCLUSION
    • Chapter 23: Growth Hormone and Insulin-like Growth Factor-I in Alzheimer’s Disease
      • Publisher Summary
      • I INTRODUCTION
      • II GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I (IGF-I) AND COGNITIVE DECLINE IN THE ELDERLY
      • III INTERACTIONS BETWEEN IGF-I SYSTEM AND ALZHEIMER’S DISEASE
      • IV GROWTH HORMONE IN ALZHEIMER’S DISEASE
      • V GROWTH HORMONE RESPONSE IN ALZHEIMER’S DISEASE
      • VI SOMATOSTATIN IN CEREBROSPINAL FLUID IN ALZHEIMER’S DISEASE
      • VII RELATIONSHIP BETWEEN ALZHEIMER’S DISEASE TREATMENT AND IGF-I SYSTEM AND GROWTH HORMONE RESPONSE TO STIMULI
      • VIII POSSIBLE USEFULNESS OF GROWTH HORMONE/IGF-I AXIS IN ALZHEIMER’S DISEASE TREATMENT
  • Section 6: Growth Hormone Replacement and Related Therapies in Central Nervous System Disorders: A Future Perspective
    • Chapter 24: Growth Hormone Antagonists: A Pharmacological Tool in Present and Future Therapies
      • Publisher Summary
      • 1 INTRODUCTION
      • II THE DISCOVERY OF GROWTH HORMONE ANTAGONISTS
      • III DEVELOPMENT OF PEGVISOMANT
      • IV PRECLINICAL TRIALS
      • V CLINICAL TRIALS
      • VI OTHER USES OF PEGVISOMANT
      • VII CONCLUSION
      • Acknowledgments
    • Chapter 25: Growth Hormone Replacement Therapy and Life Quality: Future Perspectives
      • Publisher Summary
      • I CASE STUDY: NEUROPROTECTIVE EFFECT OF GROWTH HORMONE IN SPINAL CORD INJURY
      • II GROWTH HORMONE REPLACEMENT AND LIFE QUALITY IN THE FRAIL ELDERLY
      • III GROWTH HORMONE REPLACEMENT AND QUALITY OF LIFE IN ADULTS WITH GROWTH HORMONE DEFICIENCY
  • Index

Details

No. of pages:
384
Language:
English
Copyright:
© Academic Press 2005
Published:
Imprint:
Academic Press
eBook ISBN:
9780080498164
Hardcover ISBN:
9780120884841

About the Editor

Fred Nyberg

Affiliations and Expertise

Uppsala University, Sweden

Reviews

"Because of its breadth, this book will be a useful resource for both research scientists and clinicians. For the established scientist, the chapters provide a good brush-up and ready source of references; whereas for the new clinician or scientist entering the GH-CNS field, it will provide a strong and broad introduction to the field and a fairly comprehensive basis to build upon." --BRAIN, BEHAVIOR AND IMMUNITY (September 2006)