This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists.

Key Features

Extremely distinguished list of authors Multidisciplinary character – equally suitable for chemists and biochemists Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.


Libraries Professors and group leaders Students, postdocs

Table of Contents

Introductory overviews Chapter 1. Mammalian myoglobin as a model for ligand understanding affinities and discrimination in heme proteins John S. Olson and Abhik Ghosh Chapter 2. A surfeit of biological heme-based sensors Marie-Alda Gilles-Gonzales and Gonzalo Gonzales Chapter 3. NO and NOx interactions with hemes Peter C. Ford, Susmita Bandyopadhyay, Mark D. Lim, Ivan M. Lorkovic Electronic structure and spectroscopy Chapter 4. CO, NO, and O2 as vbrational probes of heme protein active sites Thomas G. Spiro, Mohammed Ibrahim and Ingar Wasbotten Chapter 5. Nuclear resonance vibrational spectroscopy W. Robert Scheidt and Tim Sage Chapter 6. EPR and low-temperature MCD spectroscopy of ferrous heme nitrosyls Nicolai Lehnert Aspects of hemoglobins (except heme-NOx interactions) Chapter 7. Protoglobin and globin-coupled sensors Maqsudul Alam, Tracey Allen Keawe Freitas, Jennifer Saito, Xuehua(Ivy) Wan and Shaobin Hou Chapter 8. Neuroglobin and cytoglobin Thorsten Burmester and Tom Hankeln Chapter 9. Extreme pH sensitivity in the binding of oxygen to some fish hemoglobins: the Root effect Tom Brittain Chapter 10. Microbial hemoglobins: Structure, function and folding Tsuyoshi Egawa, Changyuan Lu, Dipanwita Batabyal, Masahiro Mukai and Syun-Ru Yeh Heme-NOx interactions Chapter 11. The reaction between nitrite and hemoglobin: The role of nitrite in hemoglobin-mediated hypoxic vasodilation Daniel B. Kim-Shapiro, Mark T. Gladwin, Rakesh P. Patel and Neil Hogg Chapter 12. Nitric


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© 2008
Elsevier Science
eBook ISBN:
Print ISBN:

About the editor

Abhik Ghosh

Affiliations and Expertise

Department of Chemistry, University of Tromso, Norway