The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins

1st Edition

Editors: Abhik Ghosh
Hardcover ISBN: 9780444528391
eBook ISBN: 9780080556321
Imprint: Elsevier Science
Published Date: 12th December 2007
Page Count: 614
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This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds.

The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries.

The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists.

Key Features

Extremely distinguished list of authors Multidisciplinary character – equally suitable for chemists and biochemists Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.


Libraries Professors and group leaders Students, postdocs

Table of Contents

Introductory overviews Chapter 1. Mammalian myoglobin as a model for ligand understanding affinities and discrimination in heme proteins John S. Olson and Abhik Ghosh

Chapter 2. A surfeit of biological heme-based sensors Marie-Alda Gilles-Gonzales and Gonzalo Gonzales

Chapter 3. NO and NOx interactions with hemes Peter C. Ford, Susmita Bandyopadhyay, Mark D. Lim, Ivan M. Lorkovic

Electronic structure and spectroscopy Chapter 4. CO, NO, and O2 as vbrational probes of heme protein active sites Thomas G. Spiro, Mohammed Ibrahim and Ingar Wasbotten

Chapter 5. Nuclear resonance vibrational spectroscopy W. Robert Scheidt and Tim Sage

Chapter 6. EPR and low-temperature MCD spectroscopy of ferrous heme nitrosyls Nicolai Lehnert

Aspects of hemoglobins (except heme-NOx interactions) Chapter 7. Protoglobin and globin-coupled sensors Maqsudul Alam, Tracey Allen Keawe Freitas, Jennifer Saito, Xuehua(Ivy) Wan and Shaobin Hou

Chapter 8. Neuroglobin and cytoglobin Thorsten Burmester and Tom Hankeln

Chapter 9. Extreme pH sensitivity in the binding of oxygen to some fish hemoglobins: the Root effect Tom Brittain

Chapter 10. Microbial hemoglobins: Structure, function and folding Tsuyoshi Egawa, Changyuan Lu, Dipanwita Batabyal, Masahiro Mukai and Syun-Ru Yeh

Heme-NOx interactions Chapter 11. The reaction between nitrite and hemoglobin: The role of nitrite in hemoglobin-mediated hypoxic vasodilation Daniel B. Kim-Shapiro, Mark T. Gladwin, Rakesh P. Patel and Neil Hogg

Chapter 12. Nitric


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Elsevier Science
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About the Editor

Abhik Ghosh

Affiliations and Expertise

Department of Chemistry, University of Tromso, Norway