The Sebaceous Glands

The Sebaceous Glands

Proceedings of the Brown University Symposium on the Biology of Skin, 1962

1st Edition - January 1, 1963

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  • Editors: William Montagna, Richard A. Ellis, Alene F. Silver
  • eBook ISBN: 9781483279176

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Advances in Biology of Skin, Volume 3: The Sebaceous Glands covers the proceedings of the 1962 Brown University Symposium on the Biology of Skin. The symposium considers the developmental sequences of sebaceous glands in man, their structural and functional attributes, and the analysis of skin surface lipids and their synthesis. This book is organized into 14 chapters, and starts with an introduction to the sebaceous glands. The subsequent chapter deals with the sebaceous glands in oral and lip mucosa. These topics are followed by discussions on ectopic sebaceous glands and the structure of sebaceous glands of man. Other chapters describe the effect of age and sex on the metabolism of rat, as well as the problems in the analysis of sebum. The last chapters consider the hormonal control of sebaceous glands in both animals and humans. This book will be of value to biologists and research workers.

Table of Contents

  • List of Contributors


    Chapter I The Development of Sebaceous Glands in Man

    I. Introduction

    II. Development of the Epidermis

    III. Development of the Hair Follicle

    IV. Development of the Sebaceous Glands

    V. Enzymes of the Fetal Sebaceous Glands

    VI. Summary and Conclusions

    VII. References

    Chapter II The Sebaceous Glands in Man

    I. Introduction

    II. The Microscopic Anatomy of Sebaceous Cells

    III. Histochemistry

    IV. Mechanism of Growth

    V. References

    Chapter III Comparative Aspects of Sebaceous Glands

    I. Introduction

    II. Histochemistry

    III. The Problems of Growth and Differentiation

    IV. References

    Chapter IV Sebaceous Glands in Oral and Lip Mucosa

    I. Introduction

    II. Sex Prevalence

    III. Familial Prevalence

    IV. Morphology and Histology

    V. Development

    VI. Properties and Composition of Buccal Sebum

    VII. Function

    VIII. Comparative Anatomy

    IX. Increase With Advancing Age

    X. References

    Chapter V Ectopic Sebaceous Glands

    I. Introduction

    II. Female Genitalia

    III. Male Genitalia

    IV. The Nipples and Areolae

    V. Ocular Structures

    VI. The Palms and Soles

    VII. The Parotid Glands

    VIII. The Tongue

    IX. Miscellaneous Sites

    X. General Comment

    XI. Summary and Conclusions

    XII. References

    Chapter VI The Ultrastructure of the Sebaceous Glands of Man

    I. Introduction

    II. Materials and Methods

    III. Observations

    A. The Peripheral Undifferentiated Sebaceous Cells

    B. The Partially Differentiated Cells

    C. The Fully Differentiated Cells

    IV. Conclusions

    V. References

    Chapter VII The Uses of Sebum?

    I. Introduction

    II. Phylogenetic Considerations

    III. The Lipid Film

    IV. Comparative Physiology

    V. Vitamin D

    VI. Surface Lipids as Adjuncts to the Barrier Function of Skin

    VII. Sebum as an Emulsifier: Its Role in Moisture Regulation

    A. In Vitro Studies

    B. In Vivo Studies

    C. Sebum as an Emulsifier

    VIII. The Antifungal Properties of Sebum

    IX. Antibacterial Effect of Sebum

    X. Harmful Effect of Sebum

    XI. Nice Properties of Sebum

    XII. Summary

    XIII. References

    Chapter VIII the Effect of Age and Sex on the Metabolism of the Preputial Gland of the Rat

    I. Introduction

    II. Observations

    A. Effects of Age and Sex on the Preputial Gland

    III. Discussion

    IV. Summary and Conclusions

    V. References

    Chapter IX Problems in the Analysis of Sebum

    I. Introduction

    II. Collection of Sebum

    III. Physical and Chemical Constants

    A. Melting Point

    B. Specific Gravity

    C. Viscosity

    D. Surface Tension

    E. Acid Number or Neutralization Equivalent

    F. Iodine Number

    G. Saponification Number

    H. Acetyl Number

    I. Total Nitrogen

    J. Lipid Phosphorus

    IV. Single Components

    A. Glycerol

    B. Sterols and Steroids

    C. Squalene

    V. Fraction Methods

    A. Whole Sebum

    B. Non-Saponifiable Material

    C. Urea Adduct Formation

    VI. Miscellaneous Physical Methods

    A. Fractional Distillation

    B. Ultraviolet and Infrared Spectrometry

    C. Mass Spectrometry

    D. Counter-Current Distribution

    VII. Applications of Gas Chromatography

    A. Fatty Acids

    B. Wax Alcohols

    C. Sterols

    D. Waxes

    E. Non-Saponifiable Material and Whole Sebum

    VIII. Conclusions

    IX. References

    Chapter X Studies on the Regulation of Cholesterol Synthesis in the Skin and Preputial Gland of the Rat

    I. Introduction

    II. Methods

    III. Results

    A. Demonstration of Two Pathways in Skin

    B. Effects of Sex Hormones on Sterol Synthesis

    C. Effect of Essential Fatty Acid Deficiency on Sebaceous Gland Sterols

    IV. Discussion

    V. Conclusions

    VI. References

    Chapter XI Human Skin Surface Lipids—Origin, Composition and Possible Function

    I. Introduction

    II. Sources of Human Skin Surface Lipids

    III. Chemical Composition of Human Surface Fat

    A. The Sample

    B. The Analytical Scheme

    C. The Composition

    IV. The Free Fatty Acids and Glycerides of Human Skin Surface Fat

    V. The Wax Esters and Wax Alcohols of Human Skin Surface Fat

    A. The Wax Alcohols

    B. The Wax Esters

    VI. Squalene, Sterol Esters and Free Sterols in Human Skin Surface Fat

    VII. Paraffin Hydrocarbons

    VIII. Summary

    A. Biogenesis of Sebum and Its Contribution to Human Skin Surface Fat

    B. Epidermal Lipids and Their Contribution to Human Skin Surface Fat

    IX. References

    Chapter XII The Effects of Progesterone and a Pituitary Preparation with Sebotropic Activity on Sebaceous Glands

    Chapter XIII Hormonal Control of Sebaceous Glands in Experimental Animals

    I. Introduction

    II. Methods

    A. Preparation of Whole Mounts and Sections

    B. Estimation of Alveolar Volume

    C. Estimation of Mean Alveolar Number

    D. Cell Number and Cell Volume

    E. Cell Proliferation and Turnover Time

    III. Action of Androgens

    IV. Action of Estrogens

    A. Time of Response in Immature Female Rats

    B. Effect of Estradiol on Mitosis in Immature Rats

    C. Changes During the Estrous Cycle

    D. Effect of Estradiol in Hypophysectomized and Adrenalectomized Rats

    E. Concomitant Implantation of Estradiol and Testosterone

    V. Progestogens

    A. Conflicting Results With Progesterone

    B. Progesterone in Spayed and Intact Adult Rats

    C. Progesterone in Intact Immature Rats Treated With Estradiol

    D. Progesterone in Spayed Immature Rats

    E. Large Doses of Progesterone

    VI. Synthetic Steroids

    VII. Discussion

    VIII. References

    Chapter XIV The Hormonal Control of Human Sebaceous Glands

    I. Introduction

    II. Structure and Development of the Sebaceous Glands of the Face

    III. Methods of Investigating the Effects of Hormones on Sebaceous Glands

    A. Biopsy

    B. Gravimetric Assay of Sebum Production

    IV. The Role of Androgens in the Development of the Sebaceous Glands

    A. The Responses in Sexes and Different Age Groups

    B. The Rate of Response of the Sebaceous Glands to Methyl Testosterone

    C. The Sensitivity of the Sebaceous Glands to Methyl Testosterone

    D. The Site of Action of Testosterone

    V. The Effect of Adrenal Hormones on the Human Sebaceous Glands

    VI. The Effect of Progesterone on the Sebaceous Glands

    VII. The Effects of Estrogen on the Sebaceous Glands

    A. Systemic Administration of Estrogens

    B. Local Application of Estrogens

    VIII. The Effect of Simultaneous Methyl Testosterone and Ethynyl Estradiol Administration

    IX. Effect of Gonadotropins on the Sebaceous Glands

    X. Effect of Sebotropin

    XI. Discussion and Conclusions

    XII. References

Product details

  • No. of pages: 272
  • Language: English
  • Copyright: © Pergamon 1963
  • Published: January 1, 1963
  • Imprint: Pergamon
  • eBook ISBN: 9781483279176

About the Editors

William Montagna

Affiliations and Expertise

Oregon Regional Primate Research Center, Beaverton, U.S.A.

Richard A. Ellis

Alene F. Silver

Ratings and Reviews

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  • Aldo M. Thu Dec 30 2021

    The Sebaceous Glands

    This is a classic. A landmark that illuminates the very fruitful research from the first half of the 20th century. The works by Montagna have touched me. A towering histologist.