The Science of Hormesis in Health and Longevity

The Science of Hormesis in Health and Longevity

1st Edition - October 23, 2018

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  • Editors: Suresh I. S. Rattan, Marios Kyriazi
  • Paperback ISBN: 9780128142530
  • eBook ISBN: 9780128142547

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The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

Key Features

  • Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging
  • Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions
  • Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more


Researchers of gerontology, physiology and biology; gerontologists and clinicians; medical students of medicine, gerontology, physiology and biology

Table of Contents

    1. The dose-response revolution: how hormesis became significant
    Edward J. Calabrese
    2. Mild stress-induced hormesis: hopes and challenges
    Eric Le Bourg
    3. Primary stress response pathways for preconditioning and physiological hormesis
    Suresh Rattan and Sumangala Bhattacharya

    4. Remote ischemic preconditioning as a form of hormesis
    Robert A. Kloner
    5. Exercise hormesis for health and longevity
    Zsolt Radak
    6. Nutritional hormesis in a modern environment
    Helen R. Griffiths
    7. Phyto-Hormetins in a Clinical Setting
    Iris R. Bell
    8. Intermittent fasting-dietary restriction as a biological hormetin for health benefits
    Gurcharan Kaur Sr.
    9. Hormetic Responses to Ethanol Ingestion: Focus on Moderation and Cardiovascular Protection
    Ronald J. Korthuis
    10. Thermal waters and the hormetic effects of hydrogen sulfide on inflammatory arthritis and wound healing
    Giovanni Scapagnini

    11. Hormesis through low dose radiation
    Alexander Vaiserman
    12. Metabolic stress – signaling and metabolic adaptation
    Thorsten Heinzel
    13. DNA damage-induced hormetic responses
    Christian Kosan and Zhao-Qi Wang
    14. Pathogen-induced hormetic responses
    Reinhard Wetzker and Michael Bauer
    15. Neuronal stress and its hormetic aspects
    Britta Qualmann
    16. Energetic Stress and Proteodynamics in Aging and Longevity
    Karyn L. Hamilton
    17. Repeated electromagnetic field stimulation in aging and health
    Felipe Pablo Perez

    18. Hormesis for healthy ageing
    Suresh Rattan
    19. Enhancing sports performance through hormesis
    Dick Thijsse
    20. Circadian regulation of hormesis for health and longevity
    Anita Jagota
    21. A Roadmap for Cross Operationalisation of Resilience
    Shima Beigi
    22. Mindfulness, health and longevity
    Jesper Dahlgaard, Mimi Yung Mehlsen, Malene Munk Jørgensen, Rikke Katrine Jentoft Olsen, Niels Gregersen, Anne Maj van der Velden and Antonia Sumbundu
    23. Buteyko breathing and ketogenic diet as potential hormetins in non-pharmacological metabolic approaches to health and longevity
    Misha Sakharoff
    24. Treating neurodegenerative diseases with low doses of ionizing radiation
    Jerry Milton Cuttler
    25. Interactions with technology as a cognitive, ‘healthy ageing’ hormetic stimulus
    Marios Kyriazis

Product details

  • No. of pages: 326
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: October 23, 2018
  • Imprint: Academic Press
  • Paperback ISBN: 9780128142530
  • eBook ISBN: 9780128142547

About the Editors

Suresh I. S. Rattan

Dr. Rattan is head of the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark. He is an internationally renowned biogerontologist with more than 30 years of experience in research, teaching, scientific writing and public communication. He is one of the pioneers for the testing and application of hormesis in ageing research and interventions. His research expertise include elucidating the molecular mechanisms of human cellular ageing, with respect to protein synthesis, modifications and turnover. He is the discoverer of the ageing-modulatory effects of kinetin and zeatin, which are now used in several skin care products. He has published more than 250 original research papers and reviews in international journals and books. He has extensive experience and success in compiling and editing/co-editing 15 books for various publishers. He is the founder and current Editor-in-Chief of the journal Biogerontology. He is also the author of popular science books for children in several languages, including English, Punjabi and Danish

Affiliations and Expertise

Head, Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Marios Kyriazi

Dr. Kyriazi is a medical doctor (MD) from the University of Rome, Italy, and after preclinical work in the USA, worked as a clinician in acute medicine in Cyprus, and the UK. He subsequently qualified as a Gerontologist with interest in the biology of ageing and became a Chartered Member of the academic organisation ‘Royal Society of Biology’ in the UK. He also has a post-graduate qualification in Geriatric Medicine from the Royal College of Physicians of London. Other appointments include Member of the Board of Trustees at the Mediterranean Graduate School of Applied Social Cognition, affiliate researcher at the Evolution, Complexity and Cognition Group, University of Brussels, and a Ronin Research Scholar. He co-organises the Cyprus Symposium on ‘Pathways to Indefinite Lifespans’. He is a member of several editorial boards. He is also a Member of the International Committee, Journal of the Spanish Society of Anti-ageing Medicine (SEMAL), Board Member (Directors) of the European Society of Anti-Ageing Medicine (ESAAM), a Peer-review Board Member, Anti-Ageing Conference London, among others. He portfolio comprises over 1000 articles, papers and lectures in the field of healthy ageing. Currently, he works with the ELPIs Foundation for Indefinite Lifespans to study the elimination of age-related degeneration. The research is focused on transdisciplinary models and explores common principles between biology, complexity sciences, evolution, cybernetics, neurosciences, and techno-cultural elements.

Affiliations and Expertise

Biological Gerontologist, British Longevity Society, ELPI Foundation for Indefinite Lifespans

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