The Science of Hormesis in Health and Longevity - 1st Edition - ISBN: 9780128142530

The Science of Hormesis in Health and Longevity

1st Edition

Editors: Suresh I. S. Rattan Marios Kyriazi
Paperback ISBN: 9780128142530
Imprint: Academic Press
Published Date: 1st October 2018
Page Count: 352
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Description

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

Key Features

  • Provides a comprehensive, scholarly review of the current state of hormesis in physiology, health, disease and aging
  • Includes multiple perspectives and in-depth analysis by top experts involved in cutting-edge research to provide developing, novel therapeutic strategies, as well as lifestyle interventions
  • Offers a clear understanding of hormesis’ underlying mechanisms, including details of stress-response signaling, an enriched environment, positive challenges, dose-response mechanisms, and more

Readership

Researchers of gerontology, physiology and biology; gerontologists and clinicians; medical students of medicine, gerontology, physiology and biology

Table of Contents

Section 1: HISTORY, TERMINOLOGY AND CONCEPTS
1. The revival of hormesis
2. Hopes and challenges for hormesis
3. Hormesis or adaptive homeostasis
4. Evolutionary adaptation under environmental stress

Section 2: STRESSORS AND STRESS RESPONSES
5. Oxidative stress
6. Metabolic stress
7. Genotoxic stress
8. Inflammatory and pathogen stress
9. Neuronal stress
10. Food restriction and its mimetics
11. Intermittent fasting as a hormetin
12. Mental stress
13. Aging and decreased resistance to multiple stresses

Section 3: HORMETIC MODULATION OF AGEING
14. Biological basis of ageing and its modulation through hormesis
15. Nutritional hormesis in a modern environment
16. Exercise as a paradigm for hormesis for health and longevity
17. Injuries can prolong lifespan in Drosophila melanogaster males
18. Intellectually and socially complex environment on human resilience in ageing
19. Interactions with technology as a cognitive anti-ageing hormetic stimulus

Section 4: HORMESIS AGAINST DISEASES
20. Radiation hormesis in disease prevention and treatment
21. Reduced Ovarian Cancer Incidence in Women Exposed to Low Dose Ionizing Background Radiation
22. Mitochondrial challenges in Cardiorenal Syndrome
23. Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid
24. Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations
25. Protecting neurons against cellular stress in Parkinson disease
26. Phyto-hormetins in a clincal setting

Section 5: FUTURE OF HORMETICS
27. Hormetin products in cosmetics and food supplements
28. Hopes and challenges for hormesis

Details

No. of pages:
352
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128142530

About the Editor

Suresh I. S. Rattan

Dr. Rattan is head of the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark. He is an internationally renowned biogerontologist with more than 30 years of experience in research, teaching, scientific writing and public communication. He is one of the pioneers for the testing and application of hormesis in ageing research and interventions. His research expertise include elucidating the molecular mechanisms of human cellular ageing, with respect to protein synthesis, modifications and turnover. He is the discoverer of the ageing-modulatory effects of kinetin and zeatin, which are now used in several skin care products. He has published more than 250 original research papers and reviews in international journals and books. He has extensive experience and success in compiling and editing/co-editing 15 books for various publishers. He is the founder and current Editor-in-Chief of the journal Biogerontology. He is also the author of popular science books for children in several languages, including English, Punjabi and Danish

Affiliations and Expertise

Head, Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Denmark

Marios Kyriazi

Dr. Kyriazi is a medical doctor (MD) from the University of Rome, Italy, and after preclinical work in the USA, worked as a clinician in acute medicine in Cyprus, and the UK. He subsequently qualified as a Gerontologist with interest in the biology of ageing and became a Chartered Member of the academic organisation ‘Royal Society of Biology’ in the UK. He also has a post-graduate qualification in Geriatric Medicine from the Royal College of Physicians of London. Other appointments include Member of the Board of Trustees at the Mediterranean Graduate School of Applied Social Cognition, affiliate researcher at the Evolution, Complexity and Cognition Group, University of Brussels, and a Ronin Research Scholar. He co-organises the Cyprus Symposium on ‘Pathways to Indefinite Lifespans’. He is a member of several editorial boards. He is also a Member of the International Committee, Journal of the Spanish Society of Anti-ageing Medicine (SEMAL), Board Member (Directors) of the European Society of Anti-Ageing Medicine (ESAAM), a Peer-review Board Member, Anti-Ageing Conference London, among others. He portfolio comprises over 1000 articles, papers and lectures in the field of healthy ageing. Currently, he works with the ELPIs Foundation for Indefinite Lifespans to study the elimination of age-related degeneration. The research is focused on transdisciplinary models and explores common principles between biology, complexity sciences, evolution, cybernetics, neurosciences, and techno-cultural elements.

Affiliations and Expertise

Biological Gerontologist, British Longevity Society, ELPI Foundation for Indefinite Lifespans

Ratings and Reviews