The Science, Etiology and Mechanobiology of Diabetes and its Complications

The Science, Etiology and Mechanobiology of Diabetes and its Complications

1st Edition - April 21, 2021

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  • Editor: Amit Gefen
  • eBook ISBN: 9780128210710
  • Paperback ISBN: 9780128210703

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The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.

Key Features

  • Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes
  • Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes
  • Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry


Scientists and engineers (such as biomedical engineers, materials engineers), biologists (including cell biologists and microbiologists, biophysicists and biochemists), research and development personnel in the diabetes care and medical device industry

Table of Contents

  • Contributors


    1. CHAPTER 1: Heel ulcers in patients with diabetes

    Michael Clark

    2. CHAPTER 2: Diabetic foot ulcers and their wound Management

    Norihiko Ohura, Katsuya Hisamichi

    3. CHAPTER 3: Computational modeling of the plantar tissue stresses induced by the clinical practice of off-loading of the diabetic foot

    Hadar Shaulian, Amit Gefen, Alon Wolf

    4. CHAPTER 4: Modeling effects of sustained bodyweight forces on adipose tissue microstructures and adipocytes in diabesity

    Maayan Lustig, Golan Amrani, Adi Lustig, Liran Azaria, Raz Margi, Yoni Koren,

    Avraham Kolel, Nurit Bar-Shai, Avior Exsol, Maya Atias, Amit Gefen

    5. CHAPTER 5: Mechanisms underlying vascular stiffening in obesity, insulin resistance,

    and type 2 diabetes

    Michael A. Hill, Yan Yang, Zhe Sun, Liping Zhang, James R. Sowers

    6. CHAPTER 6: Pathomechanics of diabetic foot ulceration: revisiting plantar shear and


    Metin Yavuz

    7. CHAPTER 7: Novel technologies for detection and prevention of diabetic foot ulcers

    Neil D. Reeves, Bill Cassidy, Caroline A. Abbott, Moi Hoon Yap

    8. CHAPTER 8: The role of tissue biomechanics in improving the clinical management of

    diabetic foot ulcers

    Panagiotis Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam

    9. CHAPTER 9: The mechanobiology of adipocytes in the context of diabetes: much more

    than a fat depot

    Shirley L. Yitzhak-David, Daphne Weihs

    10. CHAPTER 10: Optical Coherence Tomography to determine and visualize pathological

    skin structure changes caused by diabetes

    Raman Maiti, Roger Lewis, Daniel Parker, Matt J. Carré

    11. CHAPTER 11: Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cells

    Tasneem Bouzid, Jung Yul Lim

    12. CHAPTER 12: Clinical complications of tendon tissue mechanics due to collagen crosslinking in diabetes

    Jennifer A. Zellers, Jeremy D. Eekhoff, Simon Y. Tang, Mary K. Hastings, Spencer P. Lake

    13. CHAPTER 13: A phenomenological dashpot model for morphoelasticity for the

    contraction of scars

    F.j. Vermolen

    14. CHAPTER 14: Mechanobiology of diabetes and its complications: from mechanisms to

    effective mechanotherapies

    Chenyu Huang, Rei Ogawa

    15. CHAPTER 15: Application of tissue mechanics to clinical management of risk in the

    diabetic foot

    Daniel Parker, Farina Hashmi

    16. CHAPTER 16: Bone carriers in diabetic foot osteomyelitis

    Cristian Nicoletti

    17. CHAPTER 17: Vascular mechanobiology and metabolism

    Sarah Basehore, Jonathan Garcia, Alisa Morss Clyne

    18. CHAPTER 18: Effect of type 2 diabetes on bone cell behavior

    Rachana Vaidya, Anna Church, Lamya Karim

    19. CHAPTER 19: What makes a good device for the diabetic foot

    Evan Call, Darren F. Groberg, Nick Santamaria

    20. CHAPTER 20: Allostasis: a conceptual framework to better understand and prevent diabetic foot ulcers

    Laurel Tanner, Craig Oberg, Evan Call

    21. CHAPTER 21: Footwear for persons with diabetes at high risk for foot ulceration: offloading, effectiveness, and costs

    Sicco A. Bus

    22. CHAPTER 22: Compounding effects of diabetes in vessel formation in microvessel

    fragmentebased engineered constructs

    Omar Mourad, Blessing Nkennor, Sara S. Nunes

    23. CHAPTER 23: Dressing selection challenges in diabetic foot local treatment

    Paulo Alves, Tania Manuel, Nuno Mendes, Emília Ribeiro, Anabela Moura


Product details

  • No. of pages: 434
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: April 21, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128210710
  • Paperback ISBN: 9780128210703

About the Editor

Amit Gefen

Prof. Amit Gefen received the B.Sc. in Mechanical Engineering and M.Sc. and Ph.D. in Biomedical Engineering from Tel Aviv University in 1994, 1997, and 2001, respectively. He is currently a Full Professor with the Department of Biomedical Engineering at the Faculty of Engineering of Tel Aviv University and the Herbert J. Berman Chair in Vascular Bioengineering. The research interests of Prof. Gefen are in studying normal and pathological effects of biomechanical factors on the structure and function of cells, tissues and organs, with emphasis on applications in chronic wound research. To date, Prof. Gefen published more than 230 articles in peer-reviewed international journals, many of which on mechanobiology, cell and tissue biomechanics, with applications that are mostly in chronic wound prevention. He was awarded the best paper awards by journals such as Medical & Biological Engineering & Computing and Medical Engineering & Physics. He is the Editor-in-Chief of Clinical Biomechanics (published by Elsevier), and has also edited several books (published by Springer and others), and several Special Issues in journals such as the Annals of Biomedical Engineering, Journal of Biomechanics, Computer Methods in Biomechanics and Biomedical Engineering and more. He is also editing a book series on Mechanobiology, Tissue Engineering and Biomaterials (published by Springer), and has served as an Associate Editor or at Editorial Boards of several international journals which are ranked at the top of his field, e.g. PLoS One, the Annals of Biomedical Engineering, the Journal of Biomechanics, Medical Engineering & Physics, Computer Methods in Biomechanics and Biomedical Engineering, Journal of the Mechanical Behavior of Biomedical Materials, the Journal of Tissue Viability, Ostomy Wound Management and the Journal of Wound Care, to mention a few. In 2015, he was awarded the Editorial Excellence Award by the Annals of Biomedical Engineering and the Biomedical Engineering Society in the USA. Prof. Gefen has been the President of the European Pressure Ulcer Society (the European Pressure Ulcer Advisory Panel, EPUAP) in 2013-2015. He is a member of the World Council of Biomechanics, a Fellow of the International Academy of Medical and Biological Engineering and the European Alliance for Medical and Biological Engineering, and a Trustee of the International Society of Pediatric Wound Care. Prof. Gefen was awarded the Pressure Care career award by the World Union of Wound Healing Societies in 2016, the Experienced Investigator Award of EPUAP in 2017 and the Otto Schmitt Career Award of the International Federation of Medical & Biological Engineering in 2018 for “exceptional contributions to the advancement of the field of medical and biological engineering”. Prof. Gefen had visiting professorship appointments and distinguished fellowships in multiple UK universities including Cambridge University, the University of Southampton and the University of Huddersfield, as well as at the University of Cape Town in South Africa and the Katholieke Universiteit Leuven in Belgium. He is the founder and chair of the conference series - Wound Care: From Innovations to Clinical Trials. His research has been funded for example by the European Commission, the Israel Science Foundation, Israeli Ministry of Health, Ministry of Science, Ministry of Defense and national as well as international corporates. Prof. Gefen is advising and reviewing for the top-tier scientific journals such as the Lancet, and for large funding bodies worldwide. He also serves as a scientific advisor to the global medical device industry.

Affiliations and Expertise

Professor in Biomedical Engineering, Tel Aviv University

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