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The Science, Etiology and Mechanobiology of Diabetes and its Complications - 1st Edition - ISBN: 9780128210703, 9780128210710

The Science, Etiology and Mechanobiology of Diabetes and its Complications

1st Edition

Editor: Amit Gefen
eBook ISBN: 9780128210710
Paperback ISBN: 9780128210703
Imprint: Academic Press
Published Date: 21st April 2021
Page Count: 434
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The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia.

Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.

Key Features

  • Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes
  • Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes
  • Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry


Scientists and engineers (such as biomedical engineers, materials engineers), biologists (including cell biologists and microbiologists, biophysicists and biochemists), research and development personnel in the diabetes care and medical device industry

Table of Contents



1. CHAPTER 1: Heel ulcers in patients with diabetes

Michael Clark

2. CHAPTER 2: Diabetic foot ulcers and their wound Management

Norihiko Ohura, Katsuya Hisamichi

3. CHAPTER 3: Computational modeling of the plantar tissue stresses induced by the clinical practice of off-loading of the diabetic foot

Hadar Shaulian, Amit Gefen, Alon Wolf

4. CHAPTER 4: Modeling effects of sustained bodyweight forces on adipose tissue microstructures and adipocytes in diabesity

Maayan Lustig, Golan Amrani, Adi Lustig, Liran Azaria, Raz Margi, Yoni Koren,

Avraham Kolel, Nurit Bar-Shai, Avior Exsol, Maya Atias, Amit Gefen

5. CHAPTER 5: Mechanisms underlying vascular stiffening in obesity, insulin resistance,

and type 2 diabetes

Michael A. Hill, Yan Yang, Zhe Sun, Liping Zhang, James R. Sowers

6. CHAPTER 6: Pathomechanics of diabetic foot ulceration: revisiting plantar shear and


Metin Yavuz

7. CHAPTER 7: Novel technologies for detection and prevention of diabetic foot ulcers

Neil D. Reeves, Bill Cassidy, Caroline A. Abbott, Moi Hoon Yap

8. CHAPTER 8: The role of tissue biomechanics in improving the clinical management of

diabetic foot ulcers

Panagiotis Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam

9. CHAPTER 9: The mechanobiology of adipocytes in the context of diabetes: much more

than a fat depot

Shirley L. Yitzhak-David, Daphne Weihs

10. CHAPTER 10: Optical Coherence Tomography to determine and visualize pathological

skin structure changes caused by diabetes

Raman Maiti, Roger Lewis, Daniel Parker, Matt J. Carré

11. CHAPTER 11: Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cells

Tasneem Bouzid, Jung Yul Lim

12. CHAPTER 12: Clinical complications of tendon tissue mechanics due to collagen crosslinking in diabetes

Jennifer A. Zellers, Jeremy D. Eekhoff, Simon Y. Tang, Mary K. Hastings, Spencer P. Lake

13. CHAPTER 13: A phenomenological dashpot model for morphoelasticity for the

contraction of scars

F.j. Vermolen

14. CHAPTER 14: Mechanobiology of diabetes and its complications: from mechanisms to

effective mechanotherapies

Chenyu Huang, Rei Ogawa

15. CHAPTER 15: Application of tissue mechanics to clinical management of risk in the

diabetic foot

Daniel Parker, Farina Hashmi

16. CHAPTER 16: Bone carriers in diabetic foot osteomyelitis

Cristian Nicoletti

17. CHAPTER 17: Vascular mechanobiology and metabolism

Sarah Basehore, Jonathan Garcia, Alisa Morss Clyne

18. CHAPTER 18: Effect of type 2 diabetes on bone cell behavior

Rachana Vaidya, Anna Church, Lamya Karim

19. CHAPTER 19: What makes a good device for the diabetic foot

Evan Call, Darren F. Groberg, Nick Santamaria

20. CHAPTER 20: Allostasis: a conceptual framework to better understand and prevent diabetic foot ulcers

Laurel Tanner, Craig Oberg, Evan Call

21. CHAPTER 21: Footwear for persons with diabetes at high risk for foot ulceration: offloading, effectiveness, and costs

Sicco A. Bus

22. CHAPTER 22: Compounding effects of diabetes in vessel formation in microvessel

fragmentebased engineered constructs

Omar Mourad, Blessing Nkennor, Sara S. Nunes

23. CHAPTER 23: Dressing selection challenges in diabetic foot local treatment

Paulo Alves, Tania Manuel, Nuno Mendes, Emília Ribeiro, Anabela Moura



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© Academic Press 2021
21st April 2021
Academic Press
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About the Editor

Amit Gefen

Prof. Amit Gefen received the B.Sc. in Mechanical Engineering and M.Sc. and Ph.D. in Biomedical Engineering from Tel Aviv University in 1994, 1997, and 2001, respectively. He is currently a Full Professor with the Department of Biomedical Engineering at the Faculty of Engineering of Tel Aviv University and the Herbert J. Berman Chair in Vascular Bioengineering. The research interests of Prof. Gefen are in studying normal and pathological effects of biomechanical factors on the structure and function of cells, tissues and organs, with emphasis on applications in chronic wound research. To date, Prof. Gefen published more than 230 articles in peer-reviewed international journals, many of which on mechanobiology, cell and tissue biomechanics, with applications that are mostly in chronic wound prevention. He was awarded the best paper awards by journals such as Medical & Biological Engineering & Computing and Medical Engineering & Physics. He is the Editor-in-Chief of Clinical Biomechanics (published by Elsevier), and has also edited several books (published by Springer and others), and several Special Issues in journals such as the Annals of Biomedical Engineering, Journal of Biomechanics, Computer Methods in Biomechanics and Biomedical Engineering and more. He is also editing a book series on Mechanobiology, Tissue Engineering and Biomaterials (published by Springer), and has served as an Associate Editor or at Editorial Boards of several international journals which are ranked at the top of his field, e.g. PLoS One, the Annals of Biomedical Engineering, the Journal of Biomechanics, Medical Engineering & Physics, Computer Methods in Biomechanics and Biomedical Engineering, Journal of the Mechanical Behavior of Biomedical Materials, the Journal of Tissue Viability, Ostomy Wound Management and the Journal of Wound Care, to mention a few. In 2015, he was awarded the Editorial Excellence Award by the Annals of Biomedical Engineering and the Biomedical Engineering Society in the USA. Prof. Gefen has been the President of the European Pressure Ulcer Society (the European Pressure Ulcer Advisory Panel, EPUAP) in 2013-2015. He is a member of the World Council of Biomechanics, a Fellow of the International Academy of Medical and Biological Engineering and the European Alliance for Medical and Biological Engineering, and a Trustee of the International Society of Pediatric Wound Care. Prof. Gefen was awarded the Pressure Care career award by the World Union of Wound Healing Societies in 2016, the Experienced Investigator Award of EPUAP in 2017 and the Otto Schmitt Career Award of the International Federation of Medical & Biological Engineering in 2018 for “exceptional contributions to the advancement of the field of medical and biological engineering”. Prof. Gefen had visiting professorship appointments and distinguished fellowships in multiple UK universities including Cambridge University, the University of Southampton and the University of Huddersfield, as well as at the University of Cape Town in South Africa and the Katholieke Universiteit Leuven in Belgium. He is the founder and chair of the conference series - Wound Care: From Innovations to Clinical Trials. His research has been funded for example by the European Commission, the Israel Science Foundation, Israeli Ministry of Health, Ministry of Science, Ministry of Defense and national as well as international corporates. Prof. Gefen is advising and reviewing for the top-tier scientific journals such as the Lancet, and for large funding bodies worldwide. He also serves as a scientific advisor to the global medical device industry.

Affiliations and Expertise

Professor in Biomedical Engineering, Tel Aviv University

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