The Science, Etiology and Mechanobiology of Diabetes and its Complications

The Science, Etiology and Mechanobiology of Diabetes and its Complications

1st Edition - April 21, 2021

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  • Editor: Amit Gefen
  • eBook ISBN: 9780128210710
  • Paperback ISBN: 9780128210703

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The Science, Etiology and Mechanobiology of Diabetes and Its Complications presents the most comprehensive synthesis of contemporary global research on diabetes, covering a novel and unique mechanobiological perspective – addressing prevention, management and treatment of tissue, organ and body system damage associated with diabetes and its complications. The book provides a unique approach to communicating diabetes-associated symptoms and opens avenues for development of novel therapeutic and preventive methods. It offers descriptive pathophysiology of diabetes and its complications with great emphasis on mechanobiology. Content coverage also includes management of tissue, organ and body system damage caused by chronic hyperglycemia. Biologists, life scientists, physicians, pharmacists, biomedical engineers, medical physicists, biomathematicians and computer scientists who are interested in the state-of-science and current challenges in the mechanobiology of diabetes should find this book very useful. Likewise, medical researchers in fields such as endocrinology, cardiovascular medicine, oncology, obesity, the immune system, inflammation and wound care and others who wish to be updated about the latest achievements in this exciting arena of research will find that information here.

Key Features

  • Covers the state-of-knowledge in diabetes research from a mechanobiological perspective, including cell death and (neural, connective, adipose, vascular, renal etc.) tissue damage cascades and healing processes
  • Describes state-of-the-art technology in prevention, diagnosis, prognosis and treatment of tissue, organ and body system damage caused by chronic hyperglycemia and diabetes
  • Explores emerging research directions and future technology trends in the field of diabetes prevention and care, including common complications of diabetes (foot ulcers and amputation, peripheral neuropathy, retinal damage, renal damage, vascular and cardiac damage, connective tissue damage etc.) at the early stage of research and development in academia and industry


Scientists and engineers (such as biomedical engineers, materials engineers), biologists (including cell biologists and microbiologists, biophysicists and biochemists), research and development personnel in the diabetes care and medical device industry

Table of Contents

  • 1. Heel ulcers in patients with diabetes
    Michael Clark
    2. Diabetic foot ulcers and their wound Management
    Norihiko Ohura, Katsuya Hisamichi
    3. Computational modeling of the plantar tissue stresses induced by the clinical practice of off-loading of the diabetic foot
    Hadar Shaulian, Amit Gefen, Alon Wolf
    4. Modeling effects of sustained bodyweight forces on adipose tissue microstructures and adipocytes in diabesity
    Maayan Lustig, Golan Amrani, Adi Lustig, Liran Azaria, Raz Margi, Yoni Koren, Avraham Kolel, Nurit Bar-Shai, Avior Exsol, Maya Atias, Amit Gefen
    5. Mechanisms underlying vascular stiffening in obesity, insulin resistance, and type 2 diabetes
    Michael A. Hill, Yan Yang, Zhe Sun, Liping Zhang, James R. Sowers
    6. Pathomechanics of diabetic foot ulceration: revisiting plantar shear and temperature
    Metin Yavuz
    7. Novel technologies for detection and prevention of diabetic foot ulcers
    Neil D. Reeves, Bill Cassidy, Caroline A. Abbott, Moi Hoon Yap
    8. The role of tissue biomechanics in improving the clinical management of diabetic foot ulcers
    Panagiotis Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam
    9. The mechanobiology of adipocytes in the context of diabetes: much more than a fat depot
    Shirley L. Yitzhak-David, Daphne Weihs
    10. Optical Coherence Tomography to determine and visualize pathological skin structure changes caused by diabetes
    Raman Maiti, Roger Lewis, Daniel Parker, Matt J. Carré
    11. Effects of hyperglycemia and mechanical stimulations on differentiation fate of mesenchymal stem cells
    Tasneem Bouzid, Jung Yul Lim
    12. Clinical complications of tendon tissue mechanics due to collagen crosslinking in diabetes
    Jennifer A. Zellers, Jeremy D. Eekhoff, Simon Y. Tang, Mary K. Hastings, Spencer P. Lake
    13. A phenomenological dashpot model for morphoelasticity for the contraction of scars
    F.j. Vermolen
    14. Mechanobiology of diabetes and its complications: from mechanisms to effective mechanotherapies
    Chenyu Huang, Rei Ogawa
    15. Application of tissue mechanics to clinical management of risk in the diabetic foot
    Daniel Parker, Farina Hashmi
    16. Bone carriers in diabetic foot osteomyelitis
    Cristian Nicoletti
    17. Vascular mechanobiology and metabolism
    Sarah Basehore, Jonathan Garcia, Alisa Morss Clyne
    18. Effect of type 2 diabetes on bone cell behavior
    Rachana Vaidya, Anna Church, Lamya Karim
    19. What makes a good device for the diabetic foot
    Evan Call, Darren F. Groberg, Nick Santamaria
    20. Allostasis: a conceptual framework to better understand and prevent diabetic foot ulcers
    Laurel Tanner, Craig Oberg, Evan Call
    21. Footwear for persons with diabetes at high risk for foot ulceration: offloading, effectiveness, and costs
    Sicco A. Bus
    22. Compounding effects of diabetes in vessel formation in microvessel fragmentebased engineered constructs
    Omar Mourad, Blessing Nkennor, Sara S. Nunes
    23. Dressing selection challenges in diabetic foot local treatment
    Paulo Alves, Tania Manuel, Nuno Mendes, Emília Ribeiro, Anabela Moura

Product details

  • No. of pages: 434
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: April 21, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128210710
  • Paperback ISBN: 9780128210703

About the Editor

Amit Gefen

Professor Amit Gefen received the B.Sc. in Mechanical Engineering and M.Sc. and Ph.D. in Biomedical Engineering from Tel Aviv University in 1994, 1997, and 2001, respectively. During 2002-2003 he was a post-doctoral fellow at the University of Pennsylvania, USA. He is currently a Full Professor with the Department of Biomedical Engineering at the Faculty of Engineering of Tel Aviv University and the Herbert J. Berman Chair in Vascular Bioengineering. Prof. Gefen has also been the Head of the Ela Kodesz Institute for Medical Engineering and Physical Sciences at Tel Aviv University. The research interests of Prof. Gefen are in studying normal and pathological effects of biomechanical factors on the structure and function of cells, tissues and organs, with emphasis on applications in chronic wound research. He is the Editor-in-Chief of Clinical Biomechanics (published by Elsevier), and has also edited several books and several Special Issues in journals such as the Annals of Biomedical Engineering, Journal of Biomechanics, Computer Methods in Biomechanics and Biomedical Engineering and more. Recently, Prof. Gefen chaired the Etiology expert panel for development of the International Pressure Ulcer Prevention & Treatment Guidelines (2019) and also chaired the global panel of experts who developed the International Consensus Document for Device-related Pressure Ulcers, published by the Journal of Wound Care (2020).

Affiliations and Expertise

Professor in Biomedical Engineering, Berman Chair in Vascular Bioengineering, Tel Aviv University, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Ramat Aviv, Israel.

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