The development of organic intermediates requires high performance and original technologies. This book reviews recent work on some fifteen basic technologies in intermediates development including; hydrogenation, fluorination, chlorination, nitration, enzymatic catalysis, hydroxylation, alkylation, carboxylation and the Friedel Crafts reaction. Problems and industrial constraints involved in industrial development are highlighted from a research viewpoint and new technologies with potential for use in industry, particularly catalyst-based technologies clean chemical processes, are described. A chapter dealing with reviews on sodium amidure and polymerisation inhibitors is included.

Table of Contents

Foreword (B. Louvet, T. Ziemann). Preface (C. Jeanmart, J.M. Lehn). Acknowledgements. Introduction (J.-R. Desmurs et al.). Synthesis. ACYLATION. Friedel-Crafts acylation: Interactions between Lewis acids/acyl chlorides and Lewis acids/aryl ketones (R. Ashforth, J.-R. Desmurs). Bismuth(III) salts in the Friedel-Crafts acylation (J.-R. Desmurs et al.). Friedel-Crafts acylation of aromatics using zeolites (M. Spagnol et al.). CoCl2 catalyzed trifluoroacetylation of aromatics using trifluoroacetic anhydride (J. Ruiz et al.). ALKYLATION. Catalysis by rare earth phosphate II: Selective O-methylation of phenols by methanol in vapor phase (L. Gilbert et al.). Catalysis by rare earth phosphate III: Characterisation of samarium phosphate and samarium phosphate-cesium hydrogenophosphate as key catalysts for O-alkylation of phenols (A.M. Le Govic et al.). AROMATIC FUNCTIONALISATION. Selective functionalisation of fluoroaromatics via organosilicon intermediates (B. Bennetau et al.). Arylation of amines and alcohols catalyzed by nickel, copper or palladium complexes (H.J. Cristau et al.). The isomerisation of 1,2,4-trichlorobenzene: A theoretical study (S. Firkins). CARBOXYLATION. Carboxylation of hydroxy aromatic compounds (I. Bonneau-Gubelmann et al.). CHLORINATION. Access to polychlorophenols, chemistry of intermediates (J.-R. Desmurs et al.). Diastereoselective halogenations (P. Duhamel). ENZYMATIC CATALYSIS. Enzymatic hydrolysis of adiponitrile into 5-cyanovaleric acid, an intermediate for Nylon 6 (E. Cerbelaud et al.). FLUORINATION. Reagents with trifluoromethyl substituents (H.G. Viehe, Z. Janousek). Fluorination of aromatic compounds by halogen exchange with fluoride anions (Halex reaction) (B. Langlois et al.). 4-Fluorophenol: A key intermediate for agrochemicals and pharmaceuticals (C. Mercier, P. Youmans). Fluorodecarboxylation


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© 1996
Elsevier Science
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