The Role of Sphingolipids in Cancer Development and Therapy, Volume 117

1st Edition

Serial Volume Editors: James Norris
Hardcover ISBN: 9780123942746
eBook ISBN: 9780123944139
Imprint: Academic Press
Published Date: 31st December 2012
Page Count: 312
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Table of Contents



Chapter One. Interdiction of Sphingolipid Metabolism to Improve Standard Cancer Therapies

1 Introduction

2 Sphingolipids and Cytotoxic Chemotherapies

3 Sphingolipids and Radiation Therapy

4 Sphingolipids and Targeted Anticancer Agents

5 Concluding Remarks


Chapter Two. Diverse Functions of Ceramide in Cancer Cell Death and Proliferation

1 Structure and Metabolism of Ceramide

2 Distinct Functions of CerS1–6

3 Novel Ceramide–Protein Interactions that Regulate Ceramide Metabolism and Signaling

4 Clinical Relevance of Ceramide Metabolism and Signaling in Cancer Pathogenesis, Therapy, or Drug Resistance

5 Ceramide/Sphingosine-Based Anticancer Therapeutics

6 Conclusions


Chapter Three. Ceramide Glycosylation Catalyzed by Glucosylceramide Synthase and Cancer Drug Resistance

1 Introduction

2 Ceramide Glycosylation and GEMs

3 Ceramide Glycosylation and Cancer Drug Resistance

4 Targeting Ceramide Glycosylation to Reverse Drug Resistance

5 Prospective


Chapter Four. Use of Acid Sphingomyelinase for Cancer Therapy

1 Introduction

2 Involvement of ASM in Stress Response, Apoptosis, and Cancer Cell Resistance

3 Use of Exogenous ASM as an Adjunct in Cancer Therapy

4 Conclusions and Future Directions


Chapter Five. Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate

1 The Hypoxia-Inducible Factors Family: Regulation, Role in Cancer and Therapeutic Implication

2 What Does Sphingosine 1-Phosphate Signaling Have to Do with Hypoxia?

3 Sphingosine 1-Phosphate Signaling as a Target for AntiHypoxic Strategy?

4 Concluding Remarks


Chapter Six. Therapeutic Potential of Targeting SK1 in Human Cancers

1 Introd


Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy"

Key Features

  • Provides invaluable information on the exciting and fast-moving field of cancer research
  • This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy"
  • Outstanding and original reviews


Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.


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© Academic Press 2013
Academic Press
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About the Serial Volume Editors

James Norris Serial Volume Editor