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Chapter One. Interdiction of Sphingolipid Metabolism to Improve Standard Cancer Therapies
2 Sphingolipids and Cytotoxic Chemotherapies
3 Sphingolipids and Radiation Therapy
4 Sphingolipids and Targeted Anticancer Agents
5 Concluding Remarks
Chapter Two. Diverse Functions of Ceramide in Cancer Cell Death and Proliferation
1 Structure and Metabolism of Ceramide
2 Distinct Functions of CerS1–6
3 Novel Ceramide–Protein Interactions that Regulate Ceramide Metabolism and Signaling
4 Clinical Relevance of Ceramide Metabolism and Signaling in Cancer Pathogenesis, Therapy, or Drug Resistance
5 Ceramide/Sphingosine-Based Anticancer Therapeutics
Chapter Three. Ceramide Glycosylation Catalyzed by Glucosylceramide Synthase and Cancer Drug Resistance
2 Ceramide Glycosylation and GEMs
3 Ceramide Glycosylation and Cancer Drug Resistance
4 Targeting Ceramide Glycosylation to Reverse Drug Resistance
Chapter Four. Use of Acid Sphingomyelinase for Cancer Therapy
2 Involvement of ASM in Stress Response, Apoptosis, and Cancer Cell Resistance
3 Use of Exogenous ASM as an Adjunct in Cancer Therapy
4 Conclusions and Future Directions
Chapter Five. Hypoxia, Therapeutic Resistance, and Sphingosine 1-Phosphate
1 The Hypoxia-Inducible Factors Family: Regulation, Role in Cancer and Therapeutic Implication
2 What Does Sphingosine 1-Phosphate Signaling Have to Do with Hypoxia?
3 Sphingosine 1-Phosphate Signaling as a Target for AntiHypoxic Strategy?
4 Concluding Remarks
Chapter Six. Therapeutic Potential of Targeting SK1 in Human Cancers
1 Introduction to Sphingolipid Metabolism
2 Sphingosine Kinase: A Regulator of the Sphingolipid Signaling
3 Role of SK1 in Cancer Progression
4 Therapeutic Potential of SK1 Inhibition
5 FTY720: A Novel Clinically Applicable SK1 Inhibitor
6 Conclusions and Clinical Perspective
Chapter Seven. Sphingosine Kinase 1 in Cancer
2 SK1 is an oncogene
3 SK1/S1P signals for tumor growth and spread
Chapter Eight. Natural Products as Platforms for the Design of Sphingolipid-Related Anticancer Agents
1 The Role of Sphingolipids in Cancer
2 Fungal Metabolites as Inhibitors of SL Biosynthesis
3 Deoxysphingolipids of Marine Origin
4 Jaspine B, a Marine Heterocyclic Sphingoid
5 Other Heterocyclic Natural Sphingoids
6 α-Galactosylceramides and Structural Modifications Thereof
7 Concluding Remarks
Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy"
- Provides invaluable information on the exciting and fast-moving field of cancer research
- This thematic volume looks at "The Role of Sphingolipids in Cancer Development and Therapy"
- Outstanding and original reviews
Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.
- No. of pages:
- © Academic Press 2013
- 31st December 2012
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
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